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Maternal Hypertension

Maternal Hypertension

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The Hypertension group strategy focuses on improving outcomes for women with hypertension in pregnancy through a translational approach encompassing basic science research through to clinical trials and implementation science projects. We have adopted a multi-stranded approach to the discovery and evaluation of predictive and preventative strategies for hypertension in pregnancy and its associated complications, working in the UK and in low and middle income countries to reduce adverse maternal and perinatal outcomes. This includes the following workstreams across the group.

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1  Reducing maternal and fetal multi-organ complications in women with hypertension in pregnancy

 

Reducing adverse outcomes in women with pre-eclampsia by optimising timing of delivery

PHOENIX Trial

Improving antihypertensive management to improve maternal and perinatal outcomes PANDA Trial
Reducing several maternal morbidity and mortality through introduction of novel monitors in LIC settings CRADLE-2 study and CRADLE-3 trial
Optimising the monitoring and management of raised blood pressure during and after pregnancy Collaboration with the BuMP programme 

2  Improving diagnosis and prognosis in pre-eclampsia to enable targeted intervention

 
Investigating the links between preterm pre-eclampsia and subsequent cardiac function PHOEBE study 
Developing a prognostic test to guide timing of delivery in women with preterm delivery PEACOCK study 
Identifying women with pre-eclampsia at greatest risk through a new diagnostic test PARROT trial
Implementation of risk stratification in Brazil to reduce unnecessary preterm delivery Collaboration with the PREPARE trial 
Developing high-performing urinary diagnostic test for pre-eclampsia and superimposed pre-eclampsia PEACHES/ PAIRS study 
Understanding the structure and function of the placenta from implantation to delivery: a next generation MRI approach Collaboration with the PIP study                            

3  Implementing a new service delivery model and care pathway for women with high-risk pregnancies 

CHAMPION programme (NIHR Research Professorship together with King’s Improvement Science/ NIHR South London CLAHRC).

 

line_blueThe group 

 

 Professor Lucy Chappell                   

 

 Professor Andrew Shennan

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Professor Jane Sandall         

Professor Lucilla Poston

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 Professor Catherine Nelson-Piercy

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 Professor Guillermina Girardi

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Academic clinical lecturer



PhD students

Dr Louise Webster

Dr Kate Wiles

Dr Hannah Nathan

Dr Nicola Vousden

Dr Kate Duhig

Ms Rebecca Whybrow

Dr Louise Pealing (University of Oxford)

Dr Alison Ho

Technical & administrative staff


Dr Carolyn Gill

Research midwives


Ms Eleanor Hendy

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Clinical Trials

 

PHOENIX

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A trial to determine whether planned immediate delivery, compared to expectant management, reduces maternal complications without short or longterm (neurodevelopmental) detriment to the infant.

 PHOEBE

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A study to evaluate whether planned delivery improves postpartum maternal cardiac function through attenuation of myocardial ischaemia at time of disease in preterm pre-eclampsia.

CRADLE-2 and CRADLE-3

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A study/trial to develop and evaluate the introduction of a novel vital signs device incorporating traffic light warning system in the management of hypertension and shock in pregnancy in low-resource settings.

PEACOCK

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A study to evaluate prognostic indicators of need for delivery in women with late preterm pre-eclampsia to guide future decision making on timing of delivery.

PEACHES / PAIRS

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Studies to evaluate performance of commercially available ELISAs for discriminatory proteins and validate in further cohorts and to determine whether an abnormal misfolded protein response predates clinical signs of preeclampsia and can be translated to a novel diagnostic test.

PARROT

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A trial to evaluate prognostic indicators of need for delivery in women with late preterm pre-eclampsia to guide future decision making on timing of delivery. 

PANDA

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A feasibility study for a trial comparing labetalol and nifedipine in pregnant women with chronic hypertension, including assessment of ethnic variation in drug response.

PiP

A study to develop and optimise a combined approach using advanced MR imaging, fetal ECG and detailed placental histology to provide early identification of placental and fetal compromise thereby improving outcomes.

PREPARE

A trial to evaluate implementation of placental growth factor measurement and fullPIERS model application to women with pre-eclampsia to enable appropriate risk stratification.

BuMP

A study to develop a simple and accurate method of self-monitoring blood pressure and urine in pregnancy, to assess if self-monitoring can reduce maternal and perinatal complications from delayed diagnosis. 

CHAMPION

A programme to evaluate the implementation of a new service delivery model and care pathway for women with hypertension in pregnancy into clinical practice.

 
 
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Working with... 

 

KCL collaborators

 

External collaborators 

 

International collaborators

 

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