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Professor Metin Avkiran BSc PhD DSc FISHR

Professor of Molecular Cardiology

Avkiran,MetinThe Rayne Institute
4th Floor, Lambeth Wing
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH
Email: metin.avkiran@kcl.ac.uk

Biography

Professor Avkiran obtained his BSc Hons in Pharmacology (1983) and PhD in Cardiovascular Pharmacology (1987) from the University of Bath. In 2002, he was awarded a DSc by the same University, in recognition of his published research on the cardiac Na+/H+ exchanger. Professor Avkiran has held various research and academic appointments at UMDS and subsequently King's College London since 1987, including a 10-year Basic Science Lectureship/Senior Lectureship Award from the British Heart Foundation. He was appointed as Professor of Molecular Cardiology at King's College London in 2001.

Professor Avkiran is currently the President of the International Society for Heart Research (ISHR), which he has previously served as President Elect (2010-2013) and Secretary General (two consecutive terms; 2004-2007, 2007-2010). He has also served as the Secretary (1996-1998) and Chairman (2000-2002) of the British Society for Cardiovascular Research (BSCR), as a member of the ISHR European Section Council (1995-2001) and the ISHR World Council (2001-2004), and as the Chairman of the Myocardial Biology Panel of the British Cardiac Society (BCS). In 2000, he was the recipient of the prestigious Pfizer Award in Biology (in recognition of his work on the cardiac Na+/H+ exchanger) and an invited member of the National Institutes of Health (USA) Panel on Myocardial Resuscitation.  More recently, he received the 2012 Keith Reimer Distinguished Lecture Award of the ISHR.

He is currently an Associate Editor of the Journal of Molecular and Cellular Cardiology and serves on the Editorial Boards of Basic Research in Cardiology, Cardiovascular Research and Dialogues in Cardiovascular Medicine. He has previously served as an Associate Editor of Cardiovascular Research (1991-1995) and Pharmacology & Therapeutics (2001-2005), a Reviewing Editor of the Journal of Physiology (2011-12) and on the Editorial Boards of Circulation (2000-2004), Journal of Molecular and Cellular Cardiology (1999-2011) and the British Journal of Pharmacology (2002-2005). Professor Avkiran was Chairman of the Scientific Programme Committees of the XIX ISHR World Congress in 2007 (Bologna, Italy) and the XX ISHR World Congress in 2010 (Kyoto, Japan).

Research interests

The research in Professor Avkiran’s Molecular Cardiology Group is focused on the mechanisms underlying cardiac injury and dysfunction (e.g. arrhythmias, contractile dysfunction, infarction), particularly in the contexts of ischaemic heart disease and heart failure. The Group’s approach integrates physiological and pharmacological approaches with biochemical and molecular biological techniques, with recent and ongoing studies focused on: (1) Cardiac signalling by G protein-coupled receptors and downstream transduction pathways, with emphasis on protein kinases (particularly protein kinase D [PKD] and p90 ribosomal S6 kinase [RSK]), phosphatases (particularly type 2A protein phosphatase) and redox-sensitive mechanisms; (2) The pathophysiological roles and molecular regulation of the cardiac sarcolemmal Na+/H+ exchanger (NHE) and the therapeutic potential of pharmacological NHE inhibitors. Recent contributions include the identification and functional characterization of novel sarcomeric substrates for PKD and RSK, and the delineation of phosphorylation-dependent and independent mechanisms for the neurohormonal regulation of histone deacetylases implicated in the transcriptional control of cardiac hypertrophy.

Avkiran,MetinImage425w

Novel PKD substrates in the cardiac sarcomere, identified by the Group.

 

Group members

Career Establishment Fellow
  • Dr S Eminaga
Postdoctoral Fellows
  • Dr A Candasamy
  • Dr SL Puhl
  • Dr K Weeks
BHF Centre Core Scientist
  • Dr E Kemp
PhD Student
  • Miss A Ranieri
Research Technician
  • Dr S Reji
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