Dr James Clark BSc PhD
Lecturer in Aerospace Physiology, Programme Director for the MSc in Human & Applied Physiology
The Rayne Institute
4th Floor Lambeth Wing
St Thomas' Hospital
London. SE1 7EH
Tel: +44 (0) 20 7188 0966
Fax: +44 (0) 20 7188 0970
James Clark graduated from the University of Bath in 1995 with a degree in Applied Biology. He then completed a PhD under the supervision of Prof Colin Green and Dr Roberto Motterlini at the Northwick Park Institute for Medical Research (Harrow, UK) focussing on the pathways involved in the catabolism of haem to the antioxidants bilirubin and carbon monoxide. During this time he developed an interest in cardiovascular physiology. Working on the processes involved in ischaemic and pharmacological preconditioning during his PhD and subsequent post doctoral research he was part of the team to develop novel carbon monoxide releasing molecules (CORMs) which can be used to elucidate the functional role of carbon monoxide in biological systems.
In 2003 he was appointed a Research Associate in the Cardiovascular Division at King’s College London where he joined the group of Prof. Mike Marber and continued research on cardiac-protection and pharmacological preconditioning. In 2007 James was awarded a British Heart Foundation (BHF) Intermediate Research Fellowship to carry out work on carbon monoxide-mediated cardio-protection. In February 2010, he was appointed to a Lectureship in Applied & Human Physiology (Aerospace Physiology) within the academic department of Physiology and teaches on the undergraduate and masters’ degree course in physiology.
James is a member of the International Society for Heart Research (ISHR), the British Cardiac Society (BCS), the British Society for Cardiovascular Research (BSCR) and the Physiological Society (PhysSoc).
Research interests involve the application of both in vivo and in vitro physiological and molecular techniques to investigate the response of the myocardium to the stresses of ischaemia, reperfusion and trophy. My current research programme addresses how the activation of both protective and detrimental signalling pathways may influence the outcome of these stresses. This includes studies on the role and function of p38-mitogen-activated protein kinase in cardioprotection/injury, the physiological mechanisms and adaptations during the development of heart failure and the application of novel techniques for measuring cardiac haemodynamics and contractility.
Areas of interest include:
The signaling pathways involved in carbon monoxide (CO)-mediated cardiac protection.
The role of the p38-MAP kinase isoforms in cardiac physiology
The involvement of mTORC1 and mTORC2 in cardiac trophy during physiological and patho-physiological loading and unloading of the heart.
Developing and characterizing new methodologies for measuring cardiac function in murine models.