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Biography

Dr Politis has obtained degrees from the National Technical University of Athens, Greece and Imperial College London. As a post-doctoral research has worked in Cambridge and Oxford with Professor Dame Carol Robinson, as well as spending time in UCSF (Professor Andrej Sali). His recent work led to the development of a mass spectrometry-based hybrid method for assembly modelling of large and heterogeneous protein complexes. This work was published in Nature Methods and Nature Chemistry.

Research Interests

Understanding, describing and modulating many of the cells’ functions requires structure characterization of its macromolecular assemblies. However, the study of many heterogeneous assemblies by traditional methods remains challenging, thus impeding structural information of important biological machines. Hybrid structural biology approaches, which combine information from various sources, can address this challenge enabling insights for systems that remain elusive by a single method.

Dr Politis' group develops and applies computational and experimental methods to study the structure and function of protein assemblies. Specifically, they aim to:

 a) develop hybrid structural biology methods to predict the structure of large protein complexes,

b) perform mass spectrometry based experiments to generate structural restraints for capturing the flexibility and assembly pathways of transient complexes,

c) use the structural predictions to develop testable hypotheses for annotating the functions of biologically important proteins such as membrane embedded proteins and those involved in cell cycle.

Dr Politis' Research Portal