Professor Diane Hanger PhD

Biography

Research in my lab is focused on the two following areas:

• Tau: a protein involved in the development of pathology in Alzheimer’s disease, other dementias and related disorders. Our recent work is focusing on how abnormal formations of tau at sites involved in neural connectivity compromises the normal function of nerve cells.
• Alpha-synuclein: a protein present in Lewy bodies in the brains of people with Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy and related disorders. We are investigating the pathological role of alpha-synuclein in these disorders.

Please see my Research Staff Profile for more detail.

Find out more about my research:

• Tau phosphorylation site table

Key Publications:

• Guo et al., 2017. Roles of tau protein in health and disease. Acta Neuropathololgica.
• Bondulich, et al., 2016. Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate. Brain.
• Pooler et al., 2013. Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Reports.
• Hanger, et al., 2009. Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends in Molecular Medicine.
• Hanger et al., 2007. Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. Journal of Biological Chemistry.

View all publications

Key Collaborators:

• Dr Wendy Noble, King's College London
• Dr Francesco Tamagnini, University of Reading