Professor Kimberley Goldsmith PhD

Kimberley joined KCL in 2009 and is a Biostatistician and Clinical Trials specialist with an interest in complex psychological therapy treatments. She holds an Honours degree in Biology and MSc in Microbiology and Virology from McMaster University, as well as a Master of Public Health from Oregon Health & Science University. She was awarded a National Institute for Health Research (NIHR) Doctoral Research Fellowship and graduated with a PhD in Biostatistics from King’s College London.

Kimberley has extensive experience in clinical trials in mental health and other fields, encompassing the conduct, analysis and dissemination of several single and multi-centre clinical trials. Her interest is in the study of treatment mechanisms of psychological therapies/mediation analysis, including the novel application of longitudinal structural equation models to study mediation of treatment effects. To date this work has led to a greater understanding of therapeutic mechanisms and refinement of the treatments. It is also widely applicable to the study of treatments in other disease areas and public health interventions.

Kimberley is also interested in structural equation, latent variable and longitudinal modelling more generally. Her current interest is in bringing these quantitative methods more to the fore in implementation trials, to advance the use of methods like Bayesian modelling and person-oriented mediation analysis, and to develop methods to better integrate quantitative and qualitative data in these settings.

Research Interests: 

• Clinical Trials of Non-Pharmacologic Interventions
• Mediation Modelling
• Longitudinal Modelling
• Quantitative, individual and Bayesian modelling methods in Implementation Science
• Mixed methods/integration of quantitative and qualitative data in Implementation Science

Teaching: 

• Clinical Trials: A Practical Approach - Module for Applied Statistical Modelling & Health Informatics PGCert
• Contemporary Psychometrics - Module for Applied Statistical Modelling & Health Informatics PGCert
• Advanced Methodology sessions for the KCL Implementation Science Masterclass

Expertise and Public Engagement:

Kimberley provides statistical expertise to a number of trial steering and data monitoring committees nationally, and as a NIHR Programme Grants for Applied Research sub-committee member. She is also a former Associate Editor of the Trials journal, and currently holds this role for the Implementation Research and Practice journal. In the past she provided expert opinion to a Guardian Science Weekly podcast on whether members of the public should be able to influence scientific publication.

Articles and Publications

Kimberley Goldsmith - Pure Profile

Publications:

• A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc)
• Discernment of mediator and outcome measurement in the PACE trial
• Using a pragmatically adapted, low-cost contingency management intervention to promote heroin abstinence in individuals undergoing treatment for heroin use disorder in UK drug services (PRAISE): a cluster randomised trial
•  How and for whom does supportive adjustment to multiple sclerosis cognitive-behavioural therapy work? A mediated moderation analysis
• Assessing telephone-delivered cognitive–behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial
• Tutorial: The Practical Application of Longitudinal Structural EquationMediation Models in Clinical Trials