Biography
Manu Shankar-Hari undertook a period of clinical training in Guy's and St Thomas' Hospital NHS Trust, University College London Hospital NHS Trust, The Royal Free Hospital, St Mary's Hospital and at a number of regional district general hospitals around London. He completed MSc in Epidemiology at the London School of Hygiene and Tropical Medicine. Manu was awarded PhD in Immunology, for his research into in B-lymphocyte and immunoglobulins biology in sepsis, at King's College London.
Manu was appointed as a tenured consultant physician in Intensive Care Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust in 2009.
Manu was awarded the prestigious NIHR Clinician Scientist Award in 2016.
Manu was recognised for his contributions to sepsis research with the ANZICS Intensive Care Global rising star award in 2017 and International Sepsis Forum Lowry Fink Fellowship in 2019.
Currently, Manu leads a translational research group, located within the School of Immunology and Microbial Sciences.
Manu’s group is funded primarily by grants from the NIHR and the MRC-EME programme.
Research interests
Manu's research explores ways to improve outcomes in adult critically ill patients with sepsis and with ARDS, by linking the illness immunobiology to interventional trial design.
Our lab has two focussed research themes
- The immunobiology part of his laboratory utilises flow cytometry, mass cytometry, a cultured cell, transcriptomics, epigenetics and bioinformatics approaches to study adaptive immune system changes in sepsis and ARDS.
- The epidemiology and trial design part of his laboratory uses cohort studies, systematic reviews and large datasets to explore treatment response mechanisms, using principles of causality, modifiable determinants and dominant mechanisms in sepsis and ARDS related critical illness.
Current lab members
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Arkless, K. L., Pan, D., Shankar‐Hari, M., Amison, R. T., Page, C. P., Rahman, K. M. & Pitchford, S. C., 24 Jan 2023, (E-pub ahead of print) In: British journal of pharmacology. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/bph.16039
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Gorman, E., Shankar-Hari, M., Hopkins, P., Tunnicliffe, W. S., Perkins, G. D., Silversides, J., McGuigan, P., Jackson, C., Boyle, R., McFerran, J., McDowell, C., Campbell, C., McFarland, M., Smythe, J., Thompson, J., Williams, B., Curley, G., Laffey, J. G., Clarke, M., McAuley, D. F., & 1 othersO’Kane, C., Dec 2022, In: Trials. 23, 1, 401. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1186/s13063-022-06220-0
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Bos, L. D. J., Laffey, J. G., Ware, L. B., Heijnen, N. F. L., Sinha, P., Patel, B., Jabaudon, M., Bastarache, J. A., McAuley, D. F., Summers, C., Calfee, C. S. & Shankar-Hari, M., Dec 2022, In: Intensive Care Medicine Experimental. 10, 1, 8. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1186/s40635-022-00435-w
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the REMAP-CAP Immunoglobulin Domain UK Investigators, Nov 2022, In: Intensive Care Medicine. 48, 11, p. 1525-1538 14 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1007/s00134-022-06869-w
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Saha, R., Assouline, B., Mason, G., Douiri, A., Summers, C. & Shankar-Har, M., Nov 2022, In: Chest. 162, 5, p. 1048-1062 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.chest.2022.05.018
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Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A. C., Channon, K. M., Mills, N. L., Sheikh, A. & Hippisley-Cox, J., 6 Sep 2022, In: Circulation. 146, 10, p. 743-754 12 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1161/CIRCULATIONAHA.122.059970
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Møller, M. H., Alhazzani, W., Lewis, K., Belley-Cote, E., Granholm, A., Centofanti, J., McIntyre, W. B., Spence, J., Al Duhailib, Z., Needham, D. M., Evans, L., Reintam Blaser, A., Pisani, M. A., D’Aragon, F., Shankar-Hari, M., Alshahrani, M., Citerio, G., Arora, R. C., Mehta, S., Girard, T. D., & 6 othersRanzani, O. T., Hammond, N., Devlin, J. W., Shehabi, Y., Pandharipande, P. & Ostermann, M., Jul 2022, In: Intensive Care Medicine. 48, 7, p. 801-810 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1007/s00134-022-06660-x
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Cellone Trevelin, S., Pickering, S., Todd, K., Bishop, C., Pitcher, M., Garrido Mesa, J., Montorsi, L., Spada, F., Petrov, N., Green, A., Shankar-Hari, M., Neil, S. & Spencer, J., 27 Jan 2022, (Accepted/In press) In: Frontiers in Immunity- sub specialisation, Mucosal Immunity. Research output: Contribution to journal › Article › peer-review
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Conway Morris, A., Kohler, K. & Shankar-Hari, M., 1 Jan 2022, In: Thorax. 77, 1, p. 2-4 3 p. Research output: Contribution to journal › Editorial › peer-review. DOIs: https://doi.org/10.1136/thoraxjnl-2021-217428
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van de Veerdonk, F. L., Giamarellos-Bourboulis, E., Pickkers, P., Derde, L., Leavis, H., van Crevel, R., Engel, J. J., Wiersinga, W. J., Vlaar, A. P. J., Shankar-Hari, M., van der Poll, T., Bonten, M., Angus, D. C., van der Meer, J. W. M. & Netea, M. G., Jan 2022, In: Nature Medicine. 28, 1, p. 39-50 12 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41591-021-01643-9