Manu Shankar-Hari undertook a period of clinical training in Guy's and St Thomas' Hospital NHS Trust, University College London Hospital NHS Trust, The Royal Free Hospital, St Mary's Hospital and at a number of regional district general hospitals around London. He completed MSc in Epidemiology at the London School of Hygiene and Tropical Medicine. Manu was awarded PhD in Immunology, for his research into in B-lymphocyte and immunoglobulins biology in sepsis, at King's College London.
Manu was appointed as a tenured consultant physician in Intensive Care Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust in 2009.
Manu was awarded the prestigious NIHR Clinician Scientist Award in 2016.
Manu was recognised for his contributions to sepsis research with the ANZICS Intensive Care Global rising star award in 2017 and International Sepsis Forum Lowry Fink Fellowship in 2019.
Currently, Manu leads a translational research group, located within the School of Immunology and Microbial Sciences.
Manu’s group is funded primarily by grants from the NIHR and the MRC-EME programme.
Manu's research explores ways to improve outcomes in adult critically ill patients with sepsis and with ARDS, by linking the illness immunobiology to interventional trial design.
Our lab has two focussed research themes
- The immunobiology part of his laboratory utilises flow cytometry, mass cytometry, a cultured cell, transcriptomics, epigenetics and bioinformatics approaches to study adaptive immune system changes in sepsis and ARDS.
- The epidemiology and trial design part of his laboratory uses cohort studies, systematic reviews and large datasets to explore treatment response mechanisms, using principles of causality, modifiable determinants and dominant mechanisms in sepsis and ARDS related critical illness.
Current lab members
ICNARC COVID-19 Team, 1 Jan 2021, In : Critical Care Medicine. 49, 1, p. 102-111 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1097/CCM.0000000000004740
Carter, M. J., Shankar-Hari, M. & Tibby, S. M., Jan 2021, In : Intensive Care Medicine. 47, 1, p. 90-93 4 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1007/s00134-020-06273-2
Doidge, J. C., Gould, D. W., Ferrando-Vivas, P., Mouncey, P. R., Thomas, K., Shankar-Hari, M., Harrison, D. A. & Rowan, K. M., 12 Dec 2020, (Accepted/In press) In : American Journal of Respiratory and Critical Care Medicine. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1164/rccm.202008-3212OC
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., Walker, S., Parkinson, N., Fourman, M. H., Russell, C. D., Furniss, J., Richmond, A., Gountouna, E., Wrobel, N., Harrison, D., Wang, B., Wu, Y., Meynert, A., Griffiths, F., Oosthuyzen, W. & 248 others, , 11 Dec 2020, In : Nature. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41586-020-03065-y
Zampieri, F. G., Casey, J. D., Shankar-Hari, M., Harrell Jr., F. E. & Harhay, M. O., 3 Dec 2020, In : American Journal of Respiratory and Critical Care Medicine. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1164/rccm.202006-2381CP
Seow, J., Graham, C., Merrick, B., Acors, S., Pickering, S., Steel, K. J. A., Hemmings, O., O'Byrne, A., Kouphou, N., Galao, R. P., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Huettner, I., Jimenez-Guardeño, J. M., Lista, M. J., Temperton, N., Snell, L. B. & 22 others, , 1 Dec 2020, In : Nature Microbiology. 5, 12, p. 1598-1607 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41564-020-00813-8
Camporota, L., Sanderson, B., Dixon, A., Vasques, F., Jones, A. & Shankar-Hari, M., Dec 2020, In : British Journal of Anaesthesia. 125, 6, p. e480-e483 Research output: Contribution to journal - Letter. DOIs: https://doi.org/10.1016/j.bja.2020.08.047
Sinha, P., Calfee, C. S., Cherian, S., Brealey, D., Cutler, S., King, C., Killick, C., Richards, O., Cheema, Y., Bailey, C., Reddy, K., Delucchi, K. L., Shankar-Hari, M., Gordon, A. C., Shyamsundar, M., O'Kane, C. M., McAuley, D. F. & Szakmany, T., Dec 2020, In : The Lancet Respiratory Medicine. 8, 12, p. 1209-1218 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/S2213-2600(20)30366-0
ICNARC COVID-19 Team, 1 Nov 2020, In : Intensive Care Medicine. 46, 11, p. 2035-2047 13 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1007/s00134-020-06267-0
Carter, M. J., Fish, M., Jennings, A., Doores, K. J., Wellman, P., Seow, J., Acors, S., Graham, C., Timms, E., Kenny, J., Neil, S., Malim, M. H., Tibby, S. M. & Shankar-Hari, M., 1 Nov 2020, In : Nature Medicine. 26, 11, p. 1701-1707 7 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41591-020-1054-6