Manu Shankar-Hari undertook a period of clinical training in Guy's and St Thomas' Hospital NHS Trust, University College London Hospital NHS Trust, The Royal Free Hospital, St Mary's Hospital and at a number of regional district general hospitals around London. He completed MSc in Epidemiology at the London School of Hygiene and Tropical Medicine. Manu was awarded PhD in Immunology, for his research into in B-lymphocyte and immunoglobulins biology in sepsis, at King's College London.
Manu was appointed as a tenured consultant physician in Intensive Care Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust in 2009.
Manu was awarded the prestigious NIHR Clinician Scientist Award in 2016.
Manu was recognised for his contributions to sepsis research with the ANZICS Intensive Care Global rising star award in 2017 and International Sepsis Forum Lowry Fink Fellowship in 2019.
Currently, Manu leads a translational research group, located within the School of Immunology and Microbial Sciences.
Manu’s group is funded primarily by grants from the NIHR and the MRC-EME programme.
Manu's research explores ways to improve outcomes in adult critically ill patients with sepsis and with ARDS, by linking the illness immunobiology to interventional trial design.
Our lab has two focussed research themes
- The immunobiology part of his laboratory utilises flow cytometry, mass cytometry, a cultured cell, transcriptomics, epigenetics and bioinformatics approaches to study adaptive immune system changes in sepsis and ARDS.
- The epidemiology and trial design part of his laboratory uses cohort studies, systematic reviews and large datasets to explore treatment response mechanisms, using principles of causality, modifiable determinants and dominant mechanisms in sepsis and ARDS related critical illness.
Current lab members
Jones, A., Toft-Petersen, A. P., Shankar-Hari, M., Harrison, D. A. & Rowan, K. M., 1 Apr 2020, In : Critical Care Medicine. 48, 4, p. 466-474 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1097/CCM.0000000000004211
Shankar-Hari, M., Saha, R., Wilson, J., Prescott, H. C., Harrison, D., Rowan, K., Rubenfeld, G. D. & Adhikari, N. K. J., 1 Apr 2020, In : Intensive Care Medicine. 46, 4, p. 619-636 18 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1007/s00134-019-05908-3
Shankar-Hari, M. & Calfee, C. S., 25 Feb 2020, In : JAMA. 323, 8, p. 713-715 3 p. Research output: Contribution to journal - Editorial. DOIs: https://doi.org/10.1001/jama.2019.22524
Harhay, M. O., Young, P. J. & Shankar-Hari, M., 19 Feb 2020, In : Intensive Care Medicine. 46, 4, p. 793-795 3 p. Research output: Contribution to journal - Editorial. DOIs: https://doi.org/10.1007/s00134-020-05959-x
Fish, M., Swanson, C. M. & Shankar-Hari, M., 12 Feb 2020, Annual Update in Intensive Care and Emergency Medicine 2020. Vincent, J-L. (ed.). Cham: Springer International Publishing, p. 271-279 9 p. Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1007/978-3-030-37323-8_22
Simpson, N. B., Shankar-Hari, M., Rowan, K. M., Cecconi, M., von Dadelszen, P., Huning, E. Y-S., Magee, L. A., Payne, B. A., Quinn, A. C. & Harrison, D. A., 9 Jan 2020, In : Critical Care Medicine. p. 663-672 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1097/CCM.0000000000004223
Shankar-Hari, M., Fish, M. & Azoulay, E., 1 Jan 2020, In : Intensive Care Medicine. 46, 1, p. 119-121 3 p. Research output: Contribution to journal - Editorial. DOIs: https://doi.org/10.1007/s00134-019-05814-8
Perner, A., De Jong, A. & Shankar-Hari, M., 1 Jan 2020, In : Intensive Care Medicine. 46, 1, p. 116-118 3 p. Research output: Contribution to journal - Editorial. DOIs: https://doi.org/10.1007/s00134-019-05874-w
Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., La Rosée, P., Monneret, G., Venet, F., Bauer, M., Brunkhorst, F. M., Kox, M., Cavaillon, J-M., Uhle, F., Weigand, M. A., Flohé, S. B., Wiersinga, W. J., Martin-Fernandez, M., Almansa, R., Martin-Loeches, I. & 10 others, , 1 Dec 2019, In : Lancet Infectious Diseases. 19, 12, p. e422-e436 Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1016/S1473-3099(19)30567-5
Singer, M., Inada-Kim, M. & Shankar-Hari, M., 26 Oct 2019, In : Lancet. 394, 10208, p. 1513-1514 2 p. Research output: Contribution to journal - Letter. DOIs: https://doi.org/10.1016/S0140-6736(19)32483-3