Biography

My research investigates cellular mechanisms underlying Alzheimer’s disease and related disorders, with a focus on tau-related neurodegeneration. My main interests are:

1. Investigating how abnormal tau processing affects tau localisation and function to cause synapse and neuron loss.
2. Studying the contribution of non-neuronal cells in neurodegenerative disease.

This includes projects aimed at defining and targeting pathways by which astrocytes and neuroinflammatory cascades affect synapse and neuron health. My team has developed and characterised a range of cell and animal models to enhance research in this area, and have conducted pre-clinical studies that led to clinical trials of new drugs for the treatment of Alzheimer's. I am also an active member of King’s teaching staff and currently sit on the Alzheimer’s Research UK grant review board.

Please see my Research Staff Profile for more detail

Key publications:

• Noble et al., 2003. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. PNAS.
• Noble et al., 2009. Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB J.
• Garwood et al., 2011. Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture Cell Death & Disease.
• Croft et al., 2017. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death & Disease.
• Glennon et al., 2020. Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release. Brain Comms.

View all publications

Key collaborators:

• Professor Diane Hanger, King's College London
• Professor Pascal Derkinderen, University of Nantes
• Professor Chris Miller, King's College London
• Dr Laura Ferraiuolo, University of Sheffield