• Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trial

  Stringer, D., Gardner, L., Shaw, O., Clarke, B., Briggs, D., Worthington, J., Buckland, M., Danzi, G., Hilton, R., Picton, M., Thuraisingham, R. C., Borrows, R., Baker, R. J., McCullough, K., Stoves, J., Phanish, M. K., Shiu, K. Y., Walsh, S. B., Ahmed, A., Ayub, W., & 12 othersHegarty, J., Tinch-Taylor, R., Georgiou, E., Bidad, N., Kilic, A., Moon, Z., Horne, R., McCrone, P., Kelly, J., Murphy, C., Peacock, J. & Dorling, A., 12 Jan 2023, (E-pub ahead of print) In: EClinicalMedicine. Research output: Contribution to journal › Article › peer-review

• A transitional B cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection

  Basu, S., Dorling, A. & Chong, A., 21 Dec 2022, (Accepted/In press) In: Kidney International. Research output: Contribution to journal › Article › peer-review

• Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusion

  Chandak, P., Phillips, B. L., Bennett, D., Uwechue, R., Kessaris, N., Shaw, O., Maggs, T., Woodford, L., Veniard, D., Perera, R., Parmar, K., Hunt, B. J., Callaghan, C., Dorling, A. & Mamode, N., Dec 2022, In: EBioMedicine. 86, p. 104365 104365. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.ebiom.2022.104365

• Manipulation of Tissue Factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH.

  Wilkinson, H., Leonard, H., Robson, M., Smith, R., Tam, E., McVey, J. H., Kirchhofer, D., Chen, D. & Dorling, A., 12 Sep 2022, In: Frontiers in immunology. 13, 999871. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2022.999871

• The phenotype of HLA-binding B cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-γ production against purified HLA proteins

  Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., Aug 2022, In: Kidney International. 102, 2, p. 355-369 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2022.02.041

• The phenotype of HLA-binding B-cells from sensitised renal transplant recipients correlates with clinically prognostic patterns of IFNγ production against purified HLA proteins

  Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., 21 Jul 2022, In: Kidney International. 102, 2, p. 355-369 Research output: Contribution to journal › Article › peer-review

• Regulation of T &B cell interactions determines the clinical phenotype associated with donor-specific antibodies

  Basu, S. & Dorling, A., 20 Apr 2022, In: Kidney International. 101, 5, p. 877-879 3 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2022.02.020

• Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: A national cohort study

  Phillips, B., Ibrahim, M., Greenhall, G., Mumford, L., Dorling, A. & Callaghan, C., Oct 2021, In: American Journal of Transplantation. 21, 10, p. 3346-3355 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/ajt.16574

• Paclitaxel-assisted balloon angioplasty of venous stenosis in haemodialysis access: PAVE RCT

  Karunanithy, N., Robinson, E. J., Calder, F., Dorling, A., Peacock, J., Wang, Y., Gardner, L. M. & Robson, M., 27 Sep 2021, In: Efficacy and Mechanism Evaluation. 8, 13 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3310/eme08130

• A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas

  Karunanithy, N., Robinson, E. J., Ahmad, F., Burton, J. O., Calder, F., Coles, S., Das, N., Dorling, A., Forman, C., Jaffer, O., Lawman, S., Lakshminarayan, R., Lewlellyn, R., Peacock, J. L., Ramnarine, R., Mesa, I. R., Shaikh, S., Simpson, J., Steiner, K., Suckling, R., & 8 othersSzabo, L., Turner, D., Wadoodi, A., Wang, Y., Weir, G., Wilkins, C. J., Gardner, L. M. & Robson, M. G., Aug 2021, In: Kidney International. 100, 2, p. 447-456 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2021.02.040

Exploring the Links Between Regulatory T cell Populations and Development of HLA Antibodies in Renal Patients Awaiting Transplantation

Medical Research Council

£274,253

Basu, S.

June 2020 - May 2023

Clinical Training Fellowship

Determining the role of coagulation proteases in the development of renal fibrosis

Medical Research Council

£314,022

Leonard, H.

October 2019 - September 2022

Clinical Training Fellowship

Developing the evidence base for an innovative anti-inflammatory/anti-fibrotic therapy

King's Health Partners

£79,468

Dorling, A.

Research Grant (KHP Challenge Award 2019)

Regulatory T cells in Highly Sensitised Renal Patients to Improve Outcomes after HLA-Antibody Incompatible Transplantation

Medical Research Council

£251,886

Dudreuilh, C.

October 2018 - September 2021

Clinical Training Fellowship

Localised inhibition of thrombin at endothelial surfaces - a translational strategy to inhibit immune responses to localised antigen

Medical Research Council

£270,889

Wilkinson, H.

October 2017 - September 2020

Clinical Training Fellowship

Can differences in IFNg-to-IL-10 switching mediated by CD46 predict functional outcome after renal transplantation?

Medical Research Council

£224,047

Douthwaite, H.

October 2016 - October 2019

Clinical Training Fellowship

Manipulating human fibrocytes to prevent intimal hyperplasia

King's Health Partners

£46,667

Dorling, A.

Research Grant (KHP Challenge Award 2016)

Does the phenotype of antigen-specific anti-donor B cells determine the long-term outcome after Renal Transplantation?

Medical Research Council

£242,271

Burton, H.

October 2015 - September 2018

Clinical Training Fellowship

Optimized TacrolimuS and MMF for HLA Antibodies after Renal Transplantation (The OuTSMART study): A randomized controlled clinical trial to determine if a combined screening/treatment programme can prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies

National Institute for Health Research/Medical Research Council

£3,200,000

Dorling, A.

1 April 2013 - 30 September 2020

Research Grant (EME Programme)