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Hirota Group

Having the correct number of chromosomes (ploidy) is crucial for normal development and health. Numerical chromosome abnormalities often cause embryonic arrest and infertility, and are associated with diseases like cancer and Down syndrome. My major interest is in how ploidy is regulated in development. Using various types of mouse stem cells and germ cells as research models, we aim to reveal molecular mechanisms limiting abnormal ploidy in the body. We also investigate the role of cellular reprogramming to pluripotency in correcting the state carrying an extra chromosome. The knowledge gained will be used for establishing a novel therapy for phenotypes associated with abnormal ploidy.