Mechanisms limiting polyploidy in the body
This project focuses on mechanisms preventing a type of ploidy abnormality called polyploidy, the condition of carrying extra sets of complete genomes. Embryonic polyploidy strictly causes lethality before birth, accounting for about 15% of spontaneous abortions in humans. Focusing on early embryonic cells and germ cells, we analyse what happens to polyploid cells in the body, what distinct properties polyploid cells have compared to normal cells, and detailed mechanisms to prevent polyploidy in these cell lineages.