Skip to main content
KBS_Icon_questionmark link-ico

 

Holland Laboratory: Epigenetics and post-transcriptional gene regulation

We are interested in gene-environment interactions, with a particular focus on the molecular mechanisms linking extracellular signalling to changes in gene expression and cell behaviour in the context of infection, cancer, ageing and metabolic-related disease.

To this end, we utilise profiles established using a range of genome-wide profiling techniques to identify novel regulatory pathways and then determine the consequences of altering these for cell function.  Our goal is to elucidate how such mechanisms contribute to human disease and phenotypic diversity that cannot be accounted for purely by the underlying genetic variation. 

Group leads

Contact us

Michelle Holland - Principal Investigator