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Politis Group

The aim of the Politis lab is to develop novel methods and tools to study the conformational states and structural dynamics of macromolecular assemblies, important for their function within the cell. Central to our approach is the integration of structural mass spectrometry-based methods with advanced modelling to build 3D models of large and heterogeneous protein complexes. 

The primary focus of the group is on membrane-embedded protein complexes and in particular, membrane transporters. Membrane proteins are the gateways into the cell and perform a broad range of critical cellular functions. We strive to understand how small molecules, such a drugs and lipids, interact with membrane assemblies and to decipher mechanistic insights into their role in regulating the structure and function of membrane proteins.

For more information, please visit the Politis Group research website.