Manu Shankar-Hari leads this translational research group.
Shankar-Hari group’s research explores ways to improve outcomes in adult critically ill patients with sepsis and with ARDS, by linking the illness immunobiology with novel interventional trial designs.
Our lab has the following focussed research themes
- Immunobiology: Explore adaptive immune system changes during sepsis, during ARDS and longer-term in patients who survive sepsis. We integrate orthogonal multilevel data with repeated measurements of cellular phenotype, functional assessments, alongside corresponding transcriptomes and epigenetic landscapes.
- Epidemiology and Stratified medicine: We use early-phase randomised controlled trials, cohort studies, systematic reviews and large clinical trial datasets to (a) explore treatment effect heterogeneity; (b) identify treatable traits based on dominant biological mechanisms, and (c) modifiable proximate determinants of sepsis and ARDS.
- COVID-19 research focuses on clinical trials, translational immunology and children with PIMS-TS illness: Translational immunology in adults focuses on how the immune system responses are influenced by treatment with convalescent plasma and recombinant interleukin-7 in the respective clinical trials.
Current PhD students
Publications
Awards
2017 2022 NIHR Clinician Scientist Award, National Institute for Health Research
UK2018 2019 Lowry Fink Fellowship, International Sepsis Forum
2017 Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society
Activities

European Society of Intensive Care Medicine

UK Intensive Care Society

News coverage of research
JAMA Sepsis Webpage highlighting 2016 definitions
Grants
Health Technology Assessment programme (2019 – 2025)
Efficacy and Mechanism Evaluation Programme (2019-2021)
Efficacy and Mechanism Evaluation Programme (2017-2019)
National Institute for Health Research Clinician Scientist Award (2017-2022)
BJA/RCoA PhD studentship (2019-2022 )
Kings Commercialisation Institute Challenge Fund (2015-2016)
Publications
Awards
2017 2022 NIHR Clinician Scientist Award, National Institute for Health Research
UK2018 2019 Lowry Fink Fellowship, International Sepsis Forum
2017 Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society
Activities

European Society of Intensive Care Medicine

UK Intensive Care Society

News coverage of research
JAMA Sepsis Webpage highlighting 2016 definitions
Grants
Health Technology Assessment programme (2019 – 2025)
Efficacy and Mechanism Evaluation Programme (2019-2021)
Efficacy and Mechanism Evaluation Programme (2017-2019)
National Institute for Health Research Clinician Scientist Award (2017-2022)
BJA/RCoA PhD studentship (2019-2022 )
Kings Commercialisation Institute Challenge Fund (2015-2016)
Our Partners

Medical Research Council

National Institute of Academic Anaesthesia

UK Research and Innovation (UKRI)

Huo Family Foundation

Guy's and St Thomas' Charity

Department of Health & Social Care
Group lead
Manu Shankar-Hari
Professor in Critical Care Medicine and NIHR Clinician Scientist