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Manu Shankar-Hari leads this translational research group.  

Shankar-Hari group’s research explores ways to improve outcomes in adult critically ill patients with sepsis and with ARDS, by linking the illness immunobiology with novel interventional trial designs.

Our lab has the following focussed research themes

  1. Immunobiology: Explore adaptive immune system changes during sepsis, during ARDS and longer-term in patients who survive sepsis. We integrate orthogonal multilevel data with repeated measurements of cellular phenotype, functional assessments, alongside corresponding transcriptomes and epigenetic landscapes.
  2. Epidemiology and Stratified medicine: We use early-phase randomised controlled trials, cohort studies, systematic reviews and large clinical trial datasets to  (a) explore treatment effect heterogeneity; (b) identify treatable traits based on dominant biological mechanisms, and (c) modifiable proximate determinants of sepsis and ARDS.
  3. COVID-19 research focuses on clinical trials, translational immunology and children with PIMS-TS illness: Translational immunology in adults focuses on how the immune system responses are influenced by treatment with convalescent plasma and recombinant interleukin-7 in the respective clinical trials.

Current PhD students

Rohit Saha

Matthew Fish

Aislinn Jennings

Julie Wilson

Publications

    Awards

    2017 2022 NIHR Clinician Scientist Award, National Institute for Health Research

    UK2018 2019 Lowry Fink Fellowship, International Sepsis Forum

    2017 Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society

    Activities

    Intensive care
    European Society of Intensive Care Medicine

    microphone
    UK Intensive Care Society

    JAMA Sepsis Webpage highlighting 2016 definitions

    Grants

    Health Technology Assessment programme (2019 – 2025)

    Efficacy and Mechanism Evaluation Programme (2019-2021)

    Efficacy and Mechanism Evaluation Programme (2017-2019)

    National Institute for Health Research Clinician Scientist Award (2017-2022)

    BJA/RCoA PhD studentship (2019-2022 )

    Kings Commercialisation Institute Challenge Fund (2015-2016)

    Publications

      Awards

      2017 2022 NIHR Clinician Scientist Award, National Institute for Health Research

      UK2018 2019 Lowry Fink Fellowship, International Sepsis Forum

      2017 Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society

      Activities

      Intensive care
      European Society of Intensive Care Medicine

      microphone
      UK Intensive Care Society

      JAMA Sepsis Webpage highlighting 2016 definitions

      Grants

      Health Technology Assessment programme (2019 – 2025)

      Efficacy and Mechanism Evaluation Programme (2019-2021)

      Efficacy and Mechanism Evaluation Programme (2017-2019)

      National Institute for Health Research Clinician Scientist Award (2017-2022)

      BJA/RCoA PhD studentship (2019-2022 )

      Kings Commercialisation Institute Challenge Fund (2015-2016)

      Our Partners

      MRC new logo

      Medical Research Council

      National Institute of Academic Anaesthesia

      National Institute of Academic Anaesthesia

      UKRI 780x440

      UK Research and Innovation (UKRI)

      Huo Family Foundation

      Huo Family Foundation

      GSTC logo

      Guy's and St Thomas' Charity

      Department of health and social care

      Department of Health & Social Care

      Group lead

      Contact us

      Follow us on twitter: @msh_manu