NIHR Academic Clinical Lecturer in Paediatrics
Consultant in Intensive Care Medicine
Professor in Critical Care Medicine and NIHR Clinician Scientist
Pneumococcal VACcination to accelerate Immune Recovery in Sepsis Survivors: randomized placebo-controlled trial: VACIRISS trial
Sepsis survivors are at much higher risk of infection-related rehospitalisation and death. The aim of VACIRiSS trial is to evaluate the immunogenicity of single-dose 13-valent conjugate pneumococcal vaccine in preventing infection-related rehospitalisation or death in sepsis survivors and to collect outcome event data with the necessary precision to inform future definitive trial design.
VACIRISS trial
Cellular and molecular mechanisms of IMMunE dysfunction and Recovery from SEpsis related critical illness: an observational cohort study (IMMERSE)
IMMERSE study aims to integrate orthogonal multi-omics datasets of longitudinal (repeated) measurements of key lymphocyte phenotype, immune response signalling proteins, transcriptome and epigenome to describe the main patterns of immune trajectory. The ultimate goal is to inform future immunomodulation trials and aims to use T cell exhaustion as an example.
Defining ARDS and sepsis sub-phenotypes: a re-analysis of two trials to inform stratified medicine approach with future trials
Acute Respiratory Distress Syndrome (ARDS) and sepsis are the two most common illnesses in the critically ill, with increasing incidence and high mortality and many statistically negative trials. This research programme aims to identify homogenous groups (sub-phenotypes) such as patients with clinical or biological features or treatment response characteristics to inform future trial design by enriching patient populations likely to benefit the most from interventions.
Relationship between eligibility criteria in randomised controlled trials and ARDS clinical criteria on outcomes
Using systematic review, meta-analysis, cohort studies and risk modelling approaches, Rohit’s PhD aims to explain the impact of trial eligibility criteria on variability in outcomes between ARDS trials, variability in treatment effect between trials, sample size estimations, and evaluated design biases. The ultimate goal is to identify parsimonious variables that will improve future ARDS trial design.
COVID-19 research focuses on clinical trials, translational immunology and children with PIMS-TS illness
Translational immunology in adults focuses on how the immune system responses are influenced by treatment with convalescent plasma and recombinant interleukin-7 in the respective clinical trials.
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Gorman, E., Shankar-Hari, M., Hopkins, P., Tunnicliffe, W. S., Perkins, G. D., Silversides, J., McGuigan, P., Jackson, C., Boyle, R., McFerran, J., McDowell, C., Campbell, C., McFarland, M., Smythe, J., Thompson, J., Williams, B., Curley, G., Laffey, J. G., Clarke, M., McAuley, D. F. & 1 others, O’Kane, C., Dec 2022, In: Trials. 23, 1, 401. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1186/s13063-022-06220-0
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Bos, L. D. J., Laffey, J. G., Ware, L. B., Heijnen, N. F. L., Sinha, P., Patel, B., Jabaudon, M., Bastarache, J. A., McAuley, D. F., Summers, C., Calfee, C. S. & Shankar-Hari, M., Dec 2022, In: Intensive Care Medicine Experimental. 10, 1, 8. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1186/s40635-022-00435-w
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Møller, M. H., Alhazzani, W., Lewis, K., Belley-Cote, E., Granholm, A., Centofanti, J., McIntyre, W. B., Spence, J., Al Duhailib, Z., Needham, D. M., Evans, L., Reintam Blaser, A., Pisani, M. A., D’Aragon, F., Shankar-Hari, M., Alshahrani, M., Citerio, G., Arora, R. C., Mehta, S., Girard, T. D. & 6 others, Ranzani, O. T., Hammond, N., Devlin, J. W., Shehabi, Y., Pandharipande, P. & Ostermann, M., Jul 2022, In: Intensive Care Medicine. 48, 7, p. 801-810 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1007/s00134-022-06660-x
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Cellone Trevelin, S., Pickering, S., Todd, K., Bishop, C., Pitcher, M., Garrido Mesa, J., Montorsi, L., Spada, F., Petrov, N., Green, A., Shankar-Hari, M., Neil, S. & Spencer, J., 27 Jan 2022, (Accepted/In press) In: Frontiers in Immunity- sub specialisation, Mucosal Immunity. Research output: Contribution to journal › Article › peer-review
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Conway Morris, A., Kohler, K. & Shankar-Hari, M., 1 Jan 2022, In: Thorax. 77, 1, p. 2-4 3 p. Research output: Contribution to journal › Editorial › peer-review. DOIs: https://doi.org/10.1136/thoraxjnl-2021-217428
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van de Veerdonk, F. L., Giamarellos-Bourboulis, E., Pickkers, P., Derde, L., Leavis, H., van Crevel, R., Engel, J. J., Wiersinga, W. J., Vlaar, A. P. J., Shankar-Hari, M., van der Poll, T., Bonten, M., Angus, D. C., van der Meer, J. W. M. & Netea, M. G., Jan 2022, In: Nature Medicine. 28, 1, p. 39-50 12 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41591-021-01643-9
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Bauer, M., Shankar-Hari, M., Thomas-Rüddel, D. O. & Wetzker, R., 29 Dec 2021, In: Intensive Care Medicine Experimental. 9, 1, p. 63 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1186/s40635-021-00427-2
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Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A. C., Channon, K. M., Mills, N. L., Sheikh, A. & Hippisley-Cox, J., 14 Dec 2021, (E-pub ahead of print) In: Nature Medicine. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41591-021-01630-0
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Gutmann, C., Takov, K., Burnap, S. A., Singh, B., Ali, H., Theofilatos, K., Reed, E., Hasman, M., Nabeebaccus, A., Fish, M., McPhail, M. J., O'Gallagher, K., Schmidt, L. E., Cassel, C., Rienks, M., Yin, X., Auzinger, G., Napoli, S., Mujib, S. F., Trovato, F. & 17 others, Sanderson, B., Merrick, B., Niazi, U., Saqi, M., Dimitrakopoulou, K., Fernández-Leiro, R., Braun, S., Kronstein-Wiedemann, R., Doores, K. J., Edgeworth, J. D., Shah, A. M., Bornstein, S. R., Tonn, T., Hayday, A. C., Giacca, M., Shankar-Hari, M. & Mayr, M., Dec 2021, In: Nature Communications. 12, 1, 3406. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-021-23494-1
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Axfors, C., Janiaud, P., Schmitt, A. M., Van't Hooft, J., Smith, E. R., Haber, N. A., Abayomi, A., Abduljalil, M., Abdulrahman, A., Acosta-Ampudia, Y., Aguilar-Guisado, M., Al-Beidh, F., Alejandria, M. M., Alfonso, R. N., Ali, M., AlQahtani, M., AlZamrooni, A., Anaya, J-M., Ang, M. A. C., Aomar, I. F. & 188 others, Argumanis, L. E., Averyanov, A., Baklaushev, V. P., Balionis, O., Benfield, T., Berry, S., Birocco, N., Bonifacio, L. B., Bowen, A. C., Bown, A., Cabello-Gutierrez, C., Camacho, B., Camacho-Ortiz, A., Campbell-Lee, S., Cao, D. H., Cardesa, A., Carnate, J. M., Castillo, G. J. J., Cavallo, R., Chowdhury, F. R., Chowdhury, F. U. H., Ciccone, G., Cingolani, A., Climacosa, F. M. M., Compernolle, V., Cortez, C. F. N., Costa Neto, A., D'Antico, S., Daly, J., Danielle, F., Davis, J. S., De Rosa, F. G., Denholm, J. T., Denkinger, C. M., Desmecht, D., Díaz-Coronado, J. C., Díaz Ponce-Medrano, J. A., Donneau, A-F., Dumagay, T. E., Dunachie, S., Dungog, C. C., Erinoso, O., Escasa, I. M. S., Estcourt, L. J., Evans, A., Evasan, A. L. M., Fareli, C. J., Fernandez-Sanchez, V., Galassi, C., Gallo, J. E., Garcia, P. J., Garcia, P. L., Garcia, J. A., Garigliany, M., Garza-Gonzalez, E., Gauiran, D. T. V., Gaviria García, P. A., Giron-Gonzalez, J-A., Gómez-Almaguer, D., Gordon, A. C., Gothot, A., Grass Guaqueta, J. S., Green, C., Grimaldi, D., Hammond, N. E., Harvala, H., Heralde, F. M., Herrick, J., Higgins, A. M., Hills, T. E., Hines, J., Holm, K., Hoque, A., Hoste, E., Ignacio, J. M., Ivanov, A. V., Janssen, M., Jennings, J. H., Jha, V., King, R. A. N., Kjeldsen-Kragh, J., Klenerman, P., Kotecha, A., Krapp, F., Labanca, L., Laing, E., Landin-Olsson, M., Laterre, P-F., Lim, L-L., Lim, J., Ljungquist, O., Llaca-Díaz, J. M., López-Robles, C., López-Cárdenas, S., Lopez-Plaza, I., Lucero, J. A. C., Lundgren, M., Macías, J., Maganito, S. C., Malundo, A. F. G., Manrique, R. D., Manzini, P. M., Marcos, M., Marquez, I., Martínez-Marcos, F. J., Mata, A. M., McArthur, C. J., McQuilten, Z. K., McVerry, B. J., Menon, D. K., Meyfroidt, G., Mirasol, M. A. L., Misset, B., Molton, J. S., Mondragon, A. V., Monsalve, D. M., Moradi Choghakabodi, P., Morpeth, S. C., Mouncey, P. R., Moutschen, M., Müller-Tidow, C., Murphy, E., Najdovski, T., Nichol, A. D., Nielsen, H., Novak, R. M., O'Sullivan, M. V. N., Olalla, J., Osibogun, A., Osikomaiya, B., Oyonarte, S., Pardo-Oviedo, J. M., Patel, M. C., Paterson, D. L., Peña-Perez, C. A., Perez-Calatayud, A. A., Pérez-Alba, E., Perkina, A., Perry, N., Pouladzadeh, M., Poyato, I., Price, D. J., Quero, A. K. H., Rahman, M. M., Rahman, M. S., Ramesh, M., Ramírez-Santana, C., Rasmussen, M., Rees, M. A., Rego, E., Roberts, J. A., Roberts, D. J., Rodríguez, Y., Rodríguez-Baño, J., Rogers, B. A., Rojas, M., Romero, A., Rowan, K. M., Saccona, F., Safdarian, M., Santos, M. C. M., Sasadeusz, J., Scozzari, G., Shankar-Hari, M., Sharma, G., Snelling, T., Soto, A., Tagayuna, P. Y., Tang, A., Tatem, G., Teofili, L., Tong, S. Y. C., Turgeon, A. F., Veloso, J. D., Venkatesh, B., Ventura-Enriquez, Y., Webb, S. A., Wiese, L., Wikén, C., Wood, E. M., Yusubalieva, G. M., Zacharowski, K., Zarychanski, R., Khanna, N., Moher, D., Goodman, S. N., Ioannidis, J. P. A. & Hemkens, L. G., 20 Nov 2021, In: BMC infectious diseases. 21, 1, 1170. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1186/s12879-021-06829-7
2017 2022 NIHR Clinician Scientist Award, National Institute for Health Research
UK2018 2019 Lowry Fink Fellowship, International Sepsis Forum
2017 Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society
Health Technology Assessment programme (2019 – 2025)
Efficacy and Mechanism Evaluation Programme (2019-2021)
Efficacy and Mechanism Evaluation Programme (2017-2019)
National Institute for Health Research Clinician Scientist Award (2017-2022)
BJA/RCoA PhD studentship (2019-2022 )
Kings Commercialisation Institute Challenge Fund (2015-2016)