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Immunology, Infection & Inflammatory Disease (IIID) (Research Division) MPhil/PhD

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Overview

  • REF2014: Ranked first in the United Kingdom for Clinical Medicine, in terms of the proportion of our overall submission that was ranked 4* or 3* (Unit of Assessment 1 – Clinical Medicine).

  • Research income: >£28m over the last four years
  • Current number of research teams: 36
  • Current number of research PhD students: 45

Recent publications:

  • Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science
  • CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl AcadSci USA
  • The structural basis of T cell autoimmunity. Nature Immunology
  • Innate sensing of HIV-1 assembly by Tetherin induces NF-kB proinflammatory responses. Cell Host and Microbe
  • Nr4a1-dependent Ly6C(low) monocyte monitor endothelial cells and orchestrate their disposal. Cell
  • A revised classification of monocyte, macrophage, and dendritic cell development and subsetting. Science & Annu Rev Immunology
  • A novel linkage between lymphoid stress-surveillance and atopy. Science.
  • Epidermal Dendritic Cells promote carcinogenesis via metabolism of environmental hydrocarbons. Science
  • Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature
  • MEF2 is an in vivo immune-metabolic switch. Cell

Key information

Duration Expected to be three years FT or up to six years PT. There are four registration points throughout the year; January, April, July and October.

Study mode Full-time, Part-time

Further details

Awarding institution King's College London

Faculty Faculty of Life Sciences & Medicine

Locations

 

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Course detail

Description

Our Division uses a range of techniques from molecular genetics and biochemistry to clinical trial design to better understand the dynamic interplay between host defence mechanisms and viral and microbial determinants. These studies have exposed novel determinants of host protection against HIV-AIDS virus, and revealed how the virus depends upon key components of cell biology such as those that direct cell division. We examine what fails when host defence mechanisms mistakenly target uninfected tissues, causing autoimmune diseases such as rheumatoid arthritis and Type I Diabetes, and ask how such mechanisms respond to tumours.

One major focus is on a refined understanding of the function and turnover of monocytes; another on the characterization of a novel lymphoid stress-surveillance response; a third on the recognition of microbial infection; and a fourth on the nature of T cell dysregulation that underpins MHC-restricted autoimmune diseases. We actively consider practical approaches to enhancing host responses to pathogens and to limiting autoimmunity, and we contribute to clinical trials novel approaches to measuring disease course and treatment outcome.

Major research programmes include:

The study of lymphoid stress-surveillance in tumour rejection and in graft rejection; the mechanisms of action of human regulatory T cells; T cell development in the thymus; Factors that regulate the threshold for lymphocyte responses; Monocyte and dendritic cell function and development; The maturation of B cell responses in tissues; Approaches to immunotherapy; RNA trafficking and metabolism and its roles as in host defense and HIV pathogenesis; Viral budding mechanisms; Innate, cell-autonomous anti-viral responses and pattern recognition; Antigen non-specific activation of innate immunity; Leukocyte trafficking; B cell and T cell responses that operate at the body's surfaces; Vaccine and adjuvant design for both immunoprotection (infection / tumours); Immunosuppression (autoimmune disease); Hospital acquired infections and multi-centre clinical trialsViral vectors and genetic therapies.

We actively contribute to the Biomedical Research Centre of Guy’s and St Thomas’ Hospital Trusts, in which regard research into practical cell therapy programmes have just commenced.

We also have links with large and small pharmaceutical and biotech activities, via sponsored research agreements with Genentech, NovoNordisk, GSK, and ImmuoQure.

Course study environment

The Division currently has 45 PhD students each working on individual projects, within established teams of researchers, supervised by the Principal Investigator of the group and commonly interacting with fellow laboratory researchers on a day-today basis. Students are expected to submit their thesis within four years of the start of their studies - to achieve this they will need to work and think carefully and intensively on a daily basis. Departments run laboratory meetings, which students will be required to attend and there is a strong ethos of continued education, so students are encouraged to broaden their scientific knowledge by attending seminars in other departments within the Division. Students are supported throughout their three-year (FT) or six-year (PT) studies by a personal committee composed of the student's two Supervisors, two independent experts and a Chairperson, who is part of the Postgraduate Teaching Committee. The student has regular six-monthly reports/meetings to monitor progress. In addition, they present their work at laboratory and departmental meetings and at the annual divisional Graduate Students' Research Day.

Postgraduate training

Excellent training courses (scientific, IT and others) are available for all PhD students through King's Graduate School. Additionally, training for most laboratory techniques is available within the Division. It is expected that graduate students will attend many of these courses to help them rapidly attain the high level of technical and IT expertise required to produce top quality work.

Head of group/division

Professor Mike Malim

Contact for information

Valerie Wicksey +44 (0)20 7188 3162

Contact email

Valerie Wicksey@kcl.ac.uk, pg-healthadmissions@kcl.ac.uk

Course website

www.kcl.ac.uk/lsm/research/divisions/diiid/index.aspx

Further literature link(s)

www.kcl.ac.uk/lsm/research/divisions/diiid/index.aspx

Entry requirements

Entry requirements

Visit our admissions webpages to view our English language entry requirements.

Bachelor's degree with 2:1 honours (or overseas equivalent) in a relevant subject. A 2:2 degree may be considered only where applicants also offer a Master's of Science degree with Merit or above. 

Please do not complete an application form until you have spoken with and have confirmation from your preferred supervisor.

Application procedure

Studentships will be advertised in New Scientist Study, Nature Jobs, findaphd.com, the College’s Health Schools Studentships website or on http://www.jobs.ac.uk./

Short-listed applicants will be interviewed by at least two Academics. Proposed research projects must be approved by the School Postgraduate Research Committee before an offer can be made.

Personal statement and supporting information

No information required.

Course intake

No set number.

Application closing date

The deadlines for applications are detailed below. Once the final deadline passes for a start month in 2018, we will open the applications for the corresponding month in 2019. Please note that funding deadlines may be earlier.  

  • April 2018 entry – Application deadline: 18th February 2018 for Overseas/Home/EU students
  • July 2018 entry – Application deadline: 20th May 2018 for Overseas/Home/EU students
  • Sept 2018 entry – Application deadline: 27th July 2018 for Overseas students and 31st August for Home/EU students
  • January 2019 entry – Application deadline: 26th October 2018 for Overseas students and 3rd December 2018 for Home/EU students
  • April 2019 entry – Application deadline: 15th February 2019 for Overseas/Home/EU students
  • July 2019 entry - Application deadline: 17th May 2019 for Overseas/Home/EU students

Help and support

If you don't have a suitable qualification for direct entry to a UK university, or if English isn't your first language, our academic preparation courses can help you get ready for study in the UK.

Preparation courses

Fees and funding

UK/EU Tuition Fees 2017/18

Full time tuition fees:

£4,800 per year (MPhil/PhD)

£4,800 per year (MPhil/PhD Clinical)

Part time tuition fees:

£2,400 per year (MPhil/PhD)

£2,400 per year (MPhil/PhD Clinical)

£2,400 per year (MDRes)

UK/EU Tuition Fees 2018/19

Full time tuition fees:

£5,000 per year (MPhil/PhD)

£5,000 per year (MPhil/PhD Clinical)

Part time tuition fees:

£2,500 per year (MPhil/PhD)

£2,500 per year (MPhil/PhD Clinical)

£2,500 per year (MDRes)

Current regulations allow some students to pay UK tuition fees on the basis of their EU citizenship or residency. Until these eligibility criteria are changed, the EU tuition fee will remain the same as the UK tuition fee.

These tuition fees may be subject to additional increases in subsequent years of study, in line with King’s terms and conditions.

 

International Tuition Fees 2017/18

Full time tuition fees:

£21,000 per year (MPhil/PhD)

Part time tuition fees:

£10,500 per year (MPhil/PhD)

 

International Tuition Fees 2018/19

Full time tuition fees:

£22,050 per year (MPhil/PhD)

£42,000 per year (MPhil/PhD Clinical)

Part time tuition fees:

£11,025 per year (MPhil/PhD)

£21,000 per year (MPhil/PhD Clinical)

£21,000 per year (MDRes)

These tuition fees may be subject to additional increases in subsequent years of study, in line with King’s terms and conditions.

Financial help and support

Visit the fees and funding webpages to find out more about bursaries, scholarships, grants, tuition fees, living expenses, student loans and other financial help available at King's.


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Next steps

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Page last modified on 12 January 2018.