These interdisciplinary, global teams are now in with a chance of receiving up to $25m to make radical progress against some of cancer’s toughest challenges.

In March, Cancer Grand Challenges announced nine new challenges, with 178 interdisciplinary, world-class global teams submitting bold ideas to take them on. Teams PROSPECT and SAMBAI are amongst the 12 that have been shortlisted. They draw together a unique set of expertise and unite researchers from multiple countries.

Each team will now receive seed funding to draft their full research proposal and compete for up to $25m in funding, empowering them to rise above the traditional boundaries of geography and discipline to ultimately change outcomes for people with cancer.

Professor Spector and Dr Berry are part of team PROSPECT. The team is led by researchers from Massachusetts General Hospital and Washington University in St Louis, US, and aims to tackle the rise in the incidence of early-onset colorectal cancer by employing a disruptive, trans-disciplinary approach spanning cells, individuals and populations.

Meanwhile Team SAMBAI, led by Melissa Davis from the Morehouse School of Medicine, US, aims to build an unprecedented resource focused on breast, prostate and pancreatic cancer in people of African descent.

"We had a fantastic response from the global research community who rose to the task and submitted bold and innovative ideas to take on our new challenges. We are pleased to have a shortlist of 12 teams whose proposed research approaches we believe hold the greatest potential to make the progress against these cancer challenges that we urgently need. I'm looking forward to seeing how the teams develop their approaches further in their full applications," says Dr David Scott, Director, Cancer Grand Challenges.

Funded teams will be announced in March 2024.