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Espe  Perucha

Dr Espe Perucha

Senior Lecturer in Experimental Rheumatology

Research interests

  • Immunology

Biography

I did my PhD in Medicine in Spain. In 2006 I was recruited to KCL to work as a post-doc in the translational portfolio of Dr Maria Hernandez-Fuentes, Prof. Robert Lechler and Prof. Graham Lord laboratories. In 2012 I moved to Prof. Andre Cope’s team, where my research focused on dissecting the pathways for aberrant T cell activation in Rheumatoid Arthritis patients as part of the EU-funded BTCure project. Here, we undercovered a new role for cellular metabolism to regulate immune cell function, which ended up being the main research theme of my lab. The SpLAB started in late 2017, when I got a lecturer position at KCL. We are based at the Centre for Inflammation Biology and Cancer Immunology (CIBCI). The lab is interested on mechanisms of immune activation and tolerance in man, from molecules to cells and the whole individual. We work on understanding how the immune system activates and also regulates, with focus on the interaction between cellular metabolism and immune function. Our final aim is to find new ways to modulate the human immune response, in order to restore homeostasis (which is defective in chronic inflammation) or boost the effector arm, which may benefit the body when it fights infection or cancer.

    Research

    Perucha Lab B Effector Cells thumbnail 780x450
    SpLAB

    SpLAB is interested on mechanisms of immune activation and tolerance in man, from molecules to cells and the whole individual.

    NutrImmune Study Logo 780×440
    The NutrImmune Study

    Investigating how diet can optimise our immune response to flu vaccines. We're recruiting healthy adults, aged 40-64 years old, who consume 2+ snacks per day.

    Project status: Ongoing

    OILRIG
    Lipids and Membranes Research Interest Group

    A Lipids and Membranes Research Interest Group

      Research

      Perucha Lab B Effector Cells thumbnail 780x450
      SpLAB

      SpLAB is interested on mechanisms of immune activation and tolerance in man, from molecules to cells and the whole individual.

      NutrImmune Study Logo 780×440
      The NutrImmune Study

      Investigating how diet can optimise our immune response to flu vaccines. We're recruiting healthy adults, aged 40-64 years old, who consume 2+ snacks per day.

      Project status: Ongoing

      OILRIG
      Lipids and Membranes Research Interest Group

      A Lipids and Membranes Research Interest Group