An enhancer-based approach to studying vessel growth in development and disease

Speaker:

Professor Sarah De Val

Topic title:

'An enhancer-based approach to studying vessel growth in development and disease'

Synopsis:

Professor De Val is a BHF senior research fellow, and currently lead a research group at the Department of Physiology, Anatomy and Genetics, part of the University of Oxford. Her research aims to develop novel strategies to modulate vessel growth. Specifically, she investigates the many different transcriptional and cognate signalling pathways which regulate the growth of different types of endothelial cells, and then study the behaviour of these pathways in pathological situations. This work uses an enhancer-centric approach, in which she identifies and analyses enhancers active in different types of endothelial cells. Analysing these enhancers, which act as the one-off switch for genes, allows her team to determine the TFs and upstream signalling pathways that control gene expression in each endothelial type. Once fully delineated, these enhancers and the transgenic models which express them can then be used to study these processes in the adult and in disease states.

Hosted by:

Professor Cathy Shanahan

Our series is open to the public and King’s staff and students are encouraged to attend.