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The course provides a comprehensive introduction to trial design features used to mitigate bias, important aspects of trial design, conduct, analysis and reporting, and challenges and solutions for conducting RCTs with some focus on behavioural interventions. This will include some coverage of methods for elucidation of treatment mechanisms (e.g. mediation). Throughout the course the emphasis will be on practical issues faced by researchers in the conduct and analysis of RCTs through the lens of the mental health setting, and participants will be provided with skills to design, conduct and analyse rigorous RCTs in this research area.