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Professor Caterina A. M. La Porta and Professor Stefano Zapperi - Phase transitions in cell migration - 26 April 2022

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Join Professor Caterina A. M. La Porta and Professor Stefano Zapperi from the Center for Complexity and Biosystems at the University of Milan for a seminar in biological physics

Phase transitions in cell migration

Phase transitions from a static to a moving phase are observed in a variety of physical systems and play a key role in cellular assemblies such as healthy and cancerous tissue. Dense cellular assemblies, such as epithelial monolayers or cancer cell colonies, share many features with amorphous glassy materials, displaying slow relaxation and intermittent avalanche fluctuations. Cells can collectively flow like a fluid, but at high cell density mutual crowding leads to slowing down and arrest, as a way that is similar undergoing a jamming transition observed in disordered materials such as colloids, granular media or foams.

In this talk, we discuss how a suitable identification of the control and order parameters can shed light on the nature of phase transitions in cell migration. We also clarify the relation between the jamming-unjamming transition and the epithelial-mesenchymal transition, a process by which polarized epithelial cells acquire mesenchymal characteristics and become more motile.

The seminar will take place on Microsoft Teams - join the meeting

At this event

Sergi  Garcia-Manyes

Sergi Garcia-Manyes

Professor of Biophysics

Katelyn Spillane

Katelyn Spillane

Senior Lecturer in Experimental Biophysics

Ismael Díez-Pérez

Ismael Díez-Pérez

Professor of Nanochemistry

Carla Molteni

Carla Molteni

Professor of Physics

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