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Cellular Architecture of Colonic Inflammation

Speaker: Professor Alison Simmons, Nuffield Department of Medicine, University of Oxford 

We have taken an unbiased approach to shed light on the cellular anatomy and physiology of the colon in health and inflammatory bowel disease. By using multi-modal single cell technologies we reveal mechanisms of barrier breakdown and mucosal immune dysfunction that underpin acute colitis, highlighting new routes for therapeutic targeting.

Speaker bio: 

Alison Simmons is Professor of Gastroenterology at the Weatherall Institute of Molecular Medicine, University of Oxford and Honorary Consultant Gastroenterologist at the John Radcliffe Hospital. Her research focuses on mechanisms of immune sensing in infection and inflammation. She defined functions for NOD2 in autophagy induction and immunoregulation that are defective in Crohn’s disease. More recently she used single-cell technologies to chart intestinal cell heterogeneity and define principles of cellular remodelling in colitis. This revealed new features of host commensal mutualism in the intestine and factors governing mucosal cell cross-talk driving pathology in IBD. Alison is a Wellcome Investigator and Fellow of the Academy of Medical Sciences.

Event details

Gowland Hopkins Lecture Theatre, Hodgkin Building
Guy’s Campus
Great Maze Pond, London SE1 1UL