Pancreas organoids to decipher how cells cooperate to form organs

Speaker: Professor Ann Grapin Botton, University of Copenhagen

Speaker Biography: Professor Grapin-Botton and her group investigate the impact of the cellular and organ architecture on the cells’ fate choices and how single cells act in a community to generate an organ. To do so, they use mouse genetics, live imaging in 3D and they developed 3D in vitro “organoid” culture systems modelling development. More recently they used a human in vitro stem cell models to investigate human development. These studies are intended to gain insight into human syndromes impairing pancreas development and they guide the generation of replacement beta cells for Diabetes therapy.