Join Professor Michael Murrell of Yale University for a research seminar as part of the Force Talk series entitled "Energetic optimization during cell division".

 

Abstract:

Living systems are driven far from thermodynamic equilibrium through the continuous consumption of ambient energy. This energy is invested in the formation of complex, internal macromolecular structures and diverse spatial and temporal patterns in chemical and mechanical activities, which in turn orchestrate cell phenotypes and behaviours.

This self-organization is a result of a system's tendency to maximize entropy production while maintaining order internally. However, a system that maximally dissipates energy can achieve high levels of organization and complexity, although this comes at the cost of low thermodynamic efficiency. Despite decades of research, little is known regarding the energetic principles and optimization strategies that constrain the dissipation of energy arbitrarily far from thermodynamic equilibrium.

In this seminar, we explore energetic optimization, in studying the assembly of the cytokinetic ring, a complex structure that is an essential component of cellular reproduction and a defining aspect of living systems. Using the Xenopus Oocyte as a model system, we measure the production of entropy, as the cell approaches ring assembly and its first cell division.

We demonstrate that en route to division, the production of entropy is maximized, but insofar as the overall system is bounded by energetic efficiency, and its internal chemical and mechanical activities are subject to constraints of Onsager Reciprocity. Thus, in living systems, multiple energetic parameters are optimized simultaneously to promote and sustain life.

Speaker

Professor Michael Murrell is Professor of Biomedical Engineering and Physics and a Laboratory of Living Matter research leader at Yale Engineering.

Mechanics of Life Leverhulme DSP Force Talks Series

Force Talks is a seminar series hosted by the Mechanics of Life Leverhulme Doctoral Scholarship Programme at King's College London. We are honoured to welcome world leaders in mechanobiology.

The series aims to showcase the rapidly expanding interdisciplinary field of mechanobiology and mechanical forces. We welcome those from academia and industry to attend and take part in the discussions.

The programme is funded by the Leverhulme Trust doctoral scholarship grant "Understanding the mechanics of life".

Learn more about the Mechanics of Life Leverhulme Doctoral Scholarship Programme

How to join:

This event will take place online via Microsoft Teams. A link to register for this event to receive a calendar invitation and updates will be availble prior to the talk.

If you would like to receive updates on all upcoming Force Talks sign up to our mailing list.