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Force Talk: Professor Carsten Grashoff - Exploring Cell Adhesion Mechanics on Molecular Scales

Online

8 Mar Image advertising the Force Talks seminar series Part of Force Talks

Join Professor Carsten Grashoff from the University of Münster for a Force Talk entitled 'Exploring Cell Adhesion Mechanics on Molecular Scales.'

 

Abstract:

Recent years have seen an impressive development of molecular force sensing techniques to quantify where and when mechanosensitive proteins are exposed to mechanical loads in cells. Despite their success, it remains challenging to determine how relevant distinct force-bearing linkages are for a given cell biological process. In this seminar, I will summarize our previous work on the development and application of molecular tension sensors allowing the analysis of piconewton-scale forces acting across individual molecules in cells. I will then introduce a novel, genetically encoded, and single-molecule calibrated technology to probe the mechanics of individual protein linkages with light. Together, both methods enable the investigation of molecular-scale, mechanobiological processes and facilitate the evaluation of their physiological significance in cells.  

How to join:

This event will take place online via Microsoft Teams. Please email mechanicsoflife@kcl.ac.uk to receive the meeting link.

At this event

Sergi  Garcia-Manyes

Sergi Garcia-Manyes

Professor of Biophysics

Katelyn Spillane

Katelyn Spillane

Senior Lecturer in Experimental Biophysics


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