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Force Talk: Dr Robert Prevedel - Visualizing mechanical properties in biology using Brillouin microscopy


08MayText providing details of seminar with DNA banner at top with King's and Leverhulme Trust logosPart of Force Talks


Join Dr Robert Prevedel from EMBL Heidelberg for a Force Talk entitled "Visualizing mechanical properties in biology using Brillouin microscopy".


Across spatial scales, the mechanical properties of cells and tissues are important since they play intricate roles in determining biological function. However, standard techniques currently used to assess them exhibit intrinsic limitations. Here, an emerging technique is Brillouin microscopy: by exploiting the interaction of light with spontaneous acoustic waves intrinsically present in any sample, Brillouin microscopy (BM) enables assessment of mechanical properties in a 3D, all-optical and hence non-contact fashion. In this seminar, I will I will briefly introduce and review this emerging field before discussing various applications in biology and present our efforts to optimise the technique for fast and high-resolution live-imaging of dynamic biological processes with low-phototoxicity. In particular, by combining a line-scanning BM with a fluorescence light-sheet, we could visualise tissue-specific mechanical properties over space and time in developing model organisms such as Drosophila, Phallusia, and mouse embryos.

How to join:

This event will take place online via Microsoft Teams. Registration for this event will open shortly.

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At this event

Professor Sergi Garcia-Manyes

Professor of Biophysics

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