Human T-cell responses in allergy and immunotherapy

Human T-cell responses in allergy and immunotherapy

Speaker: Dr Erik Wambre, Benaroya Research Institute at Virginia Mason

Host: Dr Alexandra Santos

New technologies have now provided an unprecedented opportunity to compare allergen-specific T cell responses at a single cell level, both in the context of diseases and clinical intervention. 

Identification of the cellular and molecular mechanisms driving these difference has the potential to reveal drug targets and biomarkers to predict clinical response. 

The aims of this lecture are to: 
- discuss the impact of chronic high dose allergen exposure on allergen-specific CD4(+) T cell subset during Allergen-Specific Immunotherapy (AIT) 
- discuss recent advances supporting novel mechanisms for desensitization and tolerance induction during AIT.