Models, Modeling and Model-based System: Agentic AI and Generative Modeling in Biomanufacturing
King's Building, Strand Campus, London
This is a hybrid event. If you're interested in joining this seminar online, please contact netzero@kcl.ac.uk for the Teams meeting link.
Join us for a joint Department of Engineering, Centre for Host-Microbiome Interactions, and Net Zero Centre seminar with Dr Seyed Soheil Mansouri, Associate Professor in the Department of Chemical and Biochemical Engineering at the Technical University of Denmark (DTU).
Models, encapsulating biomanufacturing systems through mathematical equations, data, or symbolic representations, are pivotal for addressing complex process design and control challenges. In biomanufacturing, where nonlinear dynamics and biological variability complicate real-time monitoring, agentic AI and generative modeling revolutionise model-based systems.
Modeling constructs these representations via first-principles approaches, capturing biochemical kinetics, or data-driven methods, inferring patterns from sensor data. Hybrid techniques combine both for enhanced accuracy. Model-based systems integrate these models into tools like gPROMS or Pyomo, enabling dynamic simulation and optimisation of bioprocesses such as fermentation or protein synthesis. The Sense-Infer-Control (SIC) architecture exemplifies this integration: sensing leverages advanced sensors, inference employs agentic AI for autonomous decision-making, and control optimizes processes in real time.
Generative models synthesize novel biological designs, while quantum-enhanced agentic AI tackles complex optimizations, supporting digital twinning for virtual prototyping. Challenges include model validation against stochastic data and tool interoperability. By fusing AI with high-performance computing, these systems promise efficient, sustainable biomanufacturing, advancing pharmaceuticals and biofuels. This framework offers a robust pathway for innovation, enhancing process efficiency and product quality.
Speaker Bio:
Soheil Mansouri is an Associate Professor in the Department of Chemical and Biochemical Engineering at the Technical University of Denmark (DTU) since 2018. He was formerly an affiliate faculty member at the Sino-Danish Center for Education and Research in Beijing, China. He earned his PhD (2016) and MSc (2013) in Process Systems Engineering, both from DTU.
His research focuses on Process Systems Engineering (PSE), System Dynamics, Computational Agility (including AI and Quantum Computing), and Socio-Economic-Technological Analysis of Complex Dynamic Systems. He specializes in Process Synthesis, Design, Control, and Intensification, with applications in the chemical, pharmaceutical, and bio-manufacturing sectors.
Dr Mansouri is a senior member of the American Institute of Chemical Engineers (AIChE) and serves as the Danish representative to the Computer Aided Process Engineering (CAPE) Working Party of the European Federation of Chemical Engineers (EFCE). He is also current president of the European Committee for the Use of Computers in Chemical Engineering Education (EURECHA). Additionally, he acts as the international exchange coordinator for the AIM-Bio Program, a $27 million initiative between DTU and NC State University, funded by the Novo Nordisk Foundation. Furthermore, he contributes to the Biosolutions Zealand project, a major partnership aimed at developing a biomanufacturing hub in Denmark's Zealand Region, with total funding of approximately $12 million from the European Regional Development Fund. Since 2024, he is coordinating a 10 million EUR project funded by EU Commission to bring forward mobile and modular manufacturing of biofuels for decarbonizing the shipping industry, where they are heavily involved in developing a continent-wide integrated value chain digital twin from molecular and reaction dynamics all the way to enterprise and supply chain.
Within the domain of PSE – an interdisciplinary field in chemical and biochemical engineering – Dr Mansouri develops systematic methods and tools based on mathematical models and computational techniques for the analysis, design, operation, control, and optimisation of process systems. Recently, his work in the Biosolutions Zealand project has addressed the economics of scale in biomolecule production systems, integrating PSE with pilot-scale validation. He maintains strategic partnerships with international companies, and is a co-founder of SiC Systems Inc., Ensemble Biosystems Inc., Anaeco Inc. and Sqale ApS.
If you have any questions please don't hesitate to contact the Net Zero Centre team at netzero@kcl.ac.uk.
Please note that the Q&A should be relevant to the presentation topic. If you'd like to ask questions about other topics, please email netzero@kcl.ac.uk.
Net Zero Interdisciplinary Seminar Series
The Net Zero Interdisciplinary Seminar Series is the flagship seminar series for King’s College London’s Net Zero Centre, providing a platform for cross-pollination between academia, industry and government to develop novel research projects to achieve Net Zero.
Every month, we host a speaker to discuss a new research idea and seek contributions from audience members on a proposed challenge. A half-hour talk is followed by a discussion, and we encourage speakers to engage with colleagues on research related to our four priority areas, decarbonisation, sustainable manufacturing, equitable resource allocation and resilient infrastructure.
About us
The Net Zero Centre at King's is dedicated to addressing the challenges of decarbonising our society and reducing the environmental impact of our manufacturing, infrastructure, and cities. It serves as hub for scientific, technological and engineering research geared towards this challenge.
Based in the Faculty of Natural, Mathematical and Engineering Sciences (NMES), the Centre works across the boundaries of disciplines at King’s from geography and business to law and social science to deliver solutions for sustainable development. The Centre fosters the next generation of King’s change-makers by educating scientists and engineers on the holistic context of these challenges and developing technologically aware social scientists, lawyers, and policy makers.
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