Polygenic Risk Score Analyses

Course Description:

This one-day workshop will describe some of the fundamental theory underpinning polygenic risk score (PRS) analyses, provide hands-on practical sessions illustrating both basic and more complex PRS analyses, and illustrate the application of PRS using examples from published and ongoing research. We will use our PRSice software in computer practicals but will also describe how the same kind of analyses can be performed with alternatives (eg. LDpred). Topics covered will include: QC, pruning/clumping, the sample overlap problem, estimating pseudo-R2, ascertainment, multi-ethnic PRS, over-fitting, shrinkage methods, PRS for G*G/G*E and the potential for PRS to contribute to clinical prediction and Personalised Medicine. 

 Who is it for:

Anyone who is planning to perform Polygenic Risk Score analyses in the future for the first time, as well as those who have previously performed such analyses but feel they would like training on the more technical and advanced aspects.

Course Directors: Dr Paul O'Reilly and Dr  Sam Choi         

Course fees:

The full fee for the course is £250

Discounted fees are available for the following groups:
Public Sector workers £150
Students at other institutions £150
King's students £75
King's staff / King's health partners and SLAM employee's £75

 

To apply for this course, please see the King's short courses portal here.