This symposium will bring together top UK and Israeli scientists working in different fields of Neuroscience, related to ageing diseases and neurodegeneration, sharing new ideas and latest results to develop complementary ways of thinking. Specific areas of interests will be the importance of post-translational modifications in protein aggregation, cross-talk between ageing diseases, the frontiers of dementia studies and the development of new approaches to drug design. The event will provide an important occasion for confrontation, and a reference forum to promote new collaborations. The personal face-to-face interactions created during this meeting will be essential for increasing scientific communication and establishing new long-lasting collaborations. Our goal is not only to learn more about cutting-edge research on protein aggregation in neurodegeneration, but also to create a marketplace of ideas and tools for a more global approach to neuroscience.