Please note: this event has passed
Speaker Professor Helen Walden, Professor of Structural Biology, Head of School (Molecular Biosciences), University of Glasgow
Title Regulation of DNA repair by monoubiquitin signals
Host Riki Eggert
Abstract The Fanconi Anemia DNA repair pathway is needed to fix DNA interstrand crosslinks. At the heart of the pathway is a single monoubiquitin signal which is attached to two homologous proteins, FANCD2 and FANCI. Both the assembly and the removal of the signal are required for completion of interstrand crosslink repair. My lab focusses on understanding the mechanisms of assembly, functional consequence, and removal of specific ubiquitin signals. I will present our biochemical and structural data defining each of these steps, from how a single site is targeted for modification, what the addition of ubiquitin does to the ID2 complex, how each ubiquitin signal has a distinct function, and how the signal is removed from a specific site
Sponsored by Frontiers in Molecular Biosciences.

Event details
Harris Lecture TheatreHodgkin Building
Guy's Campus, London SE1 1UL