Speaker:

A/Professor Mahmoud Abdellatif

A/Prof. Mahmoud Abdellatif leads the Cardiovascular Ageing Group at the Division of Cardiology, Medical University of Graz. After qualifying in clinical medicine, he earned two Master’s degrees, one in Cardiovascular Pathophysiology (University of Porto) and another in Clinical Trials (University of Oxford), followed by a PhD in Molecular Medicine from the Medical University of Graz. He trained as a Marie Curie fellow in the laboratory of Guido Kroemer in Paris. Currently, he coordinates the ERA4Health-funded European project Energizing the Failing Heart (Ener-LIGHT) and serves as a key researcher in the Austrian Science Fund (FWF) Cluster of Excellence Metabolic Control of Aging and Disease (MetAge). His research focuses on autophagy and cardiovascular ageing and has been recognized with several awards, including the prestigious Elisabeth Lutz Prize of the Austrian Academy of Sciences.

Title:

'Targeting Autophagy Checkpoints in Cardiovascular Aging and Disease'

Abstract

Normal circulatory function is a key determinant of disease-free life expectancy, or healthspan. As cardiovascular diseases continue to rise globally, they remain the leading contributors to morbidity, disability and mortality. In contrast, preserving cardiovascular health is critical to maintaining both healthspan and lifespan. Emerging evidence suggests that cardiovascular ageing may not only precede but actively drive systemic, age-related decline. This talk will focus on the cellular homeostatic process of autophagy - whose dysfunction is a primary hallmark of ageing with particular relevance to cardiac health - and explore how its therapeutic modulation may help reduce residual cardiovascular risk in older individuals.

Host:

TBC

Our series is open to the public and King’s staff and students are encouraged to attend.