King's College London

THIS VACANCY IS OPEN TO INTERNAL APPLICANTS ONLY

About us:

This is a research support post in Mishto lab within the Centre for Inflammation Biology and Cancer Immunology (CIBCI) at the Guy’s campus of King’s College London. This post could include experiments carried out at the Francis Crick Institute in Mishto lab.

About the role:

The post aims to identify HLA-I epitopes and validate them with different techniques.

The successful candidate will be expected to lead, under the supervision of the group leader, a research whose principal aims are:

(i) discovery noncanonical (mutated) epitopes relevant in cancer immunotherapy.

(ii) isolating CD8+ T cell clones specific for HLA-I-restricted neoepitopes carrying recurrent driver mutations in cancer, and cloning their TCRs to investigate the epitope generation in cancer cells;

(iii) investigate the neoepitope antigenicity in peripheral blood of cancer patients.

Detailed knowledge of applied cellular and molecular biology and immunobiology, biochemistry and cloning would be highly advantageous.

This is a full time post (35 Hours per week), and you will be offered an a fixed term contract until 31/12/26

About you:

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. A PhD in Cell or Molecular Biology, Immunology or a related subject. Applications of PhD students who already started the RD1 procedure in 2025 are accepted.
2. Experience of mammalian cell culture (both primary and cell lines).
3. Excellent knowledge and understanding of cell biology, molecular immunology, antigen presentation, T and B cell biology.
4. Documented experience in TCR isolation and cloning in vectors.
5. Successful experience in identification of noncanonical epitope candidates in multi-omics.
6. Documented experience in in vitro digestion with purified proteasomes and analysis of mass spectrometry RAW files.
7. Documented experience in peptide elution from MHC-I complexes.

Desirable criteria

1. Evidence of active collaboration with dry lab and co-development of algorithm for the prediction of epitopes.

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.

As part of this commitment to equality, diversity and inclusion and through this appointment process, it is our aim to develop candidate pools that include applicants from all backgrounds and communities.

We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘ How we Recruit’ pages.