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Irving Group

Professor Malcolm Irving, FRS

Professor of Biophysics

Randall Division of Cell and Molecular Biophysics
New Hunt’s House
Guy’s Campus
London SE1 1UL
Email: malcolm.irving@kcl.ac.uk

Biography

Education

  • BA (Cantab) 1974 First Class Honours
  • MA 1978
  • MSc 1976 (London)
  • PhD 1979 (London)

Fellowships

  • Fellow of the Royal Society
  • Fellow of the Academy of Medical Sciences
  • Fellow of King’s College London

Current editorial boards

  • Biophysical Journal
  • Journal of Muscle Research & Cell Motility

Current grant agency responsibilities

  • EPSRC Life Sciences College
  • MRC College of Experts

Selected publications

  • Irving, M., Lombardi, V., Piazzesi, G. & Ferenczi, M.A. (1992). Myosin head movements are synchronous with the elementary force-generating process in muscle. Nature 357, 156-158.
  • Lombardi, V., Piazzesi, G., Ferenczi, M.A., Thirlwell, H., Dobbie, I. & Irving, M. (1995). Elastic distortion of myosin heads and repriming of the working stroke in muscle. Nature 374, 553-555.
  • Irving, M., Allen, T. StC., Sabido-David, C., Craik, J.S., Brandmeier, B., Kendrick-Jones, J., Corrie, J.E.T., Trentham D.R. & Goldman, Y.E. (1995). Tilting of the light chain region of myosin during step length changes and active force generation in skeletal muscle
    Large title text
    Puff image . Nature 375, 688-691.
  • Dobbie, I., Linari, M., Piazzesi, G., Reconditi, M., Koubassova, N., Ferenczi, M.A., Lombardi, V. and Irving, M. (1998). Elastic bending and active tilting of myosin heads during muscle contraction. Nature 396, 383-387.
  • Corrie, J. E. T., Brandmeier, B. D., Ferguson, R. E., Trentham, D. R., Kendrick-Jones, J., Hopkins, S. C., van der Heide, U.A., Goldman Y. E., Sabido-David, C., Dale, R. E., Criddle, S. & Irving, M. (1999). Dynamic measurement of myosin light-chain domain tilt and twist in muscle contraction. Nature 400, 425-430.
  • Linari, M., Piazzesi, G., Dobbie, I., Koubassova, N., Reconditi, M., Narayanan, T., Diat, O., Irving, M., and Lombardi, V. (2000). Interference fine structure and sarcomere length dependence of the axial X-ray pattern from active single muscle fibres. Proc. Natl. Acad. Sci. USA 97, 7226,7231.
  • Irving, M., Piazzesi, G., Lucii, L., Sun, Y.-B., Harford, J.J., Dobbie, I.M., Ferenczi, M.A., Reconditi, M. & Lombardi. V. (2000). Conformation of the myosin motor during force generation in skeletal muscle. Nature Structural Biology, 7, 482-485.
  • Piazzesi, G., Reconditi, M., Linari, M., Lucii, L., Sun, Y.-B., Narayanan, T., Boesecke, P., Lombardi, V. and Irving, M. (2002). Mechanism of force generation by myosin heads in skeletal muscle. Nature 415, 659-662.
  • Ferguson, R.E., Sun, Y.-B., Mercier, P., Brack, A.S., Sykes, B.D., Corrie, J.E.T., Trentham, D.R. and Irving, M. (2003) In situ Orientations of Protein Domains: Troponin C in Skeletal Muscle Fibers. Molecular Cell 11, 865-874
  • Mercier, P., Ferguson, R.E., Irving, M., Corrie, J.E.T., Trentham, D.R. and Sykes, B.D. (2003). The NMR structure of a bifunctional rhodamine labeled Troponin C in complex with the regulatory ‘switch’ peptide from Troponin I; implications for in situ fluorescence studies in muscle fibers. Biochemistry 42, 4333-4348.
  • Reconditi, M., Linari, M., Lucii, L., Stewart, A., Sun, Y.-B., Boesecke, P., Narayanan, T., Fischetti, R.F., Irving, T., Piazzesi, G., Irving, M. and Lombardi, V. (2004). The myosin motor in muscle generates a smaller and slower working stroke at higher load. Nature 428, 578-581.
  • Sleep, J.A., Irving, M. & Burton, K. (2005). The ATP hydrolysis and phosphate release steps control the time course of force development in rabbit skeletal muscle. J Physiol. 563, 671–687.
  • Sun, Y.-B., Brandmeier, B. and Irving, M. (2006). Structural changes in troponin in response to Ca2+ and myosin binding to thin filaments during activation of skeletal muscle. Proc. Natl. Acad. Sci. USA 103, 17771-17776.
  • Piazzesi, G., Reconditi, M., Linari, M., Lucii, L., Bianco, P., Brunello, E., Decostre, V., Stewart, A., Gore, D.B., Irving, T.C., Irving, M. and Lombardi, V. (2007). Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke size. Cell 131, 784-795.
  • Brunello, E., Reconditi, M., Elangovan, R., Linari, M., Sun, Y.-B., Narayanan, T., Panine, P., Piazzesi, G., Irving, M. and Lombardi, V. (2007). Skeletal muscle resists stretch by rapid binding of the second motor domain of myosin to actin. Proc. Natl. Acad. Sci. (USA) 104, 20114-119.
  • Knowles, A.C., Ferguson, R.E., Brandmeier, B.D., Sun, Y.-B., Trentham, D.R. and Irving, M. (2008). Orientation of the essential light chain region of myosin in relaxed, active and rigor muscle. Biophys. J. 95, 3882-3891.
  • de Simone, A., Corrie, J.E.T., Dale, R.E., Irving, M. & Fraternali, F. (2008). Conformation and Dynamics of a Rhodamine Probe Attached at Two Sites on a Protein: Implications for Molecular Structure Determination in situ. J. Am. Chem. Soc. 130, 17120-8.
  • Sun, Y.-B., Lou, F. & Irving, M. (2009). Calcium- and myosin-dependent changes in troponin structure during activation of heart muscle. J. Physiol. 587, 155-163.
  • Reconditi M., Brunello, E., Linari, M., Bianco, P., Narayanan, T., Panine, P., Piazzesi, G., Lombardi, V. and Irving, M. (2011). Motion of myosin head domains during activation and force development in skeletal muscle. Proc. Natl. Acad. Sci. (USA), 108, 7236-7240.
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