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Pfuhl Group

Dr Mark Pfuhl

Reader in Cardiovascular Structural Biology

Cardiovascular Division and Randall Division


  • Dr. rer nat. from EMBL Heidelberg / Freie Universität Berlin
  • Diplom in Biochemistry from Freie Universität Berlin

Past positions

  • 2001 - 2010: Lecturer, University of Leicester
  • 1998 - 2006: Royal Society University Research Fellow
  • 1996 - 1998: EMBO long term postdoctoral fellowship, University College London
  • 1996: EMBO short term postdoctoral fellowship, Université de Haute Normandie, France


  • EMBL studentship, 1991
  • Royal Society URF: 1998


Biochemical society

Research interests

Structural and functional studies of proteins involved in muscle signalling and regulation with a special emphasis on heart muscle and heart disease; regulation of kinase activity; structural biology of inherited diseases in the cardiovascular system; relationship of sequence to structure in multidomain proteins.

Recent publications

  • R. Croasdale, F. J. Ivins, F. Muskett, T. Daviter, D. J. Scott, T. Hardy, S. J. Smerdon, A. M. Fry, M. Pfuhl, “An undecided coiled-coil: the leucine zipper of Nek2 kinase exhibits atypical conformation exchange dynamics”, in the press, J. Biol. Chem. 06/2011
  • D. Philippe, A. Ababou, X. Yang, R. Ghosh, T. Daviter, J.E. Ladbury, M. Pfuhl, "Making Ends Meet: The Importance of the N- and C-termini for the Structure, Stability and Function of the Third SH3 Domain of Cin85", Biochemistry 50, 3649-3659, 2011
  • M. Pfuhl, S. Al-Sarayreh, M. El-Mezgueldi, "The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR Spectroscopy", Biophys. J. 100, 1718-1728, 2011
  • J. Ratti, E. Rostkova, M. Gautel, M. Pfuhl, "Structure and interactions of myosin binding protein domain C0: Cardiac specific regulation of myosin at its neck?, J. Biol. Chem. 286, 12650-12658, 2011
  • S. Schroder, F. Fraternali, X. Quan, D. Scott, F. Qian, M. Pfuhl, "When a module is not a domain: the case of the REJ module and the redefinition of the architecture of polycystin-1", Biochem. J. 435, 651-660, 2011
  • A. Ababou, M. Pfuhl, J. D. Ladbury, “Novel Insights into Binding Mechanisms of CIN85 SH3 Domains to Cbl Proteins: Solution based Investigations and in vivo Implications”, J. Mol. Biol. 387, 1120-1136, 2009
  • A. Ababou, E. Rostkova, S. Mistry, C. Le Masurier, M. Gautel, M. Pfuhl, "Myosin Binding Protein C (MyBP-C) Positioned to Play a Key Role in Regulation of Muscle Contraction: Structure an Interactions of domain C1", J. Mol. Biol. 384, 615-630, 2008
  • A. Ababou, M. Pfuhl, J. D. Ladbury, "The binding stoichiometry of CIN85 SH3 domain A and Cbl-b", Nat. Struct. Mol. Biol., 15, 890-891, 2008


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