Dr Peter Zammit
Professor Cell Biology
Randall Division of Cellular and Molecular Biophysics
New Hunt's House
London SE1 1UL
Skeletal muscle is an archetypal adult stem cell model, in which maintenance, growth and repair of functionally specialised post-mitotic cells is achieved by recruitment of undifferentiated precursors. My core research has been directed at understanding how muscle stem cells are regulated in healthy, aged and diseased skeletal muscle. The functional unit of skeletal muscle is the myofibre: a giant syncytial cell maintained by hundreds of post-mitotic myonuclei. The routine needs for myonuclear homeostasis, together with the more sporadic demands for hypertrophy and repair, are performed by muscle satellite cells. These resident stem cells are normally mitotically quiescent in mature muscle, and so must first be activated to undergo extensive proliferation to generate myoblasts that eventually differentiate to provide new myonuclei.
The main themes of the group at King’s College London currently include investigating the transcriptional and signaling control of satellite cell activation and cell fate choice, together with examining pathomechanisms and potential therapies for Emery-Dreifuss muscular dystrophy and Fascioscapulohumeral muscular dystrophy, and in cancers such as rhabdomyosarcoma.
A satellite cell on an isolated muscle fibre immunolabelled for Pax7 (red - nuclear) and Caveolin 1 (green - membrane)
- OLIGO 2018 OXFORD, St. Hilda’s College Oxford, UK, April 2018
- Muscle Development, Regeneration and Disease 2018, Berlin, Germany April, 2018
- Co-Chair-FSH Society Facioscapulohumeral Muscular Dystrophy 2018 International Research Congress & Research Planning Meetings, Las Vegas, June 2018
- Lay talk at 2018 FSHD Connect: The FSH Society’s International Network Meeting for FSHD Families, Clinicians, and Researchers, Las Vegas, June 2018
- FASEB Skeletal Muscle Satellite Cells and Regeneration, Steamboat Springs, Colorado, USA, July 2018