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21 April 2023

Latest publications from the Randall

Take a look at the latest publications from the Randall Centre for Cell & Molecular Biophysics

Research Lab

View our latest research outputs in full on our Pure page.

Recent publications include:

Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking Swan, A. H., Schindler, R. F. R., Savarese, M., Mayer, I., Rinné, S., Bleser, F., Schänzer, A., Hahn, A., Sabatelli, M., Perna, F., Chapman, K., Pfuhl, M., Spivey, A. C., Decher, N., Udd, B., Tasca, G. & Brand, T., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 4.

Extracellular matrix assembly stress initiates Drosophila central nervous system morphogenesis Serna Morales, E., Sánchez Sánchez, B., Marcotti, S., Nichols, A., Bhargava, A., Dragu, A., Hirvonen, L., Díaz-de-la-Loza, M-C., Mink, M., Cox, S., Rayfield, E., Lee, R. M., Hobson, C. M., Chew, T-L. & Stramer, B., 21 Apr 2023, In: Developmental Cell.

Optimisation of energy production and central carbon metabolism in a non-respiring eukaryote Alam, S., Gu, Y., Reichert, P., Bähler, J. & Oliferenko, S., 18 Apr 2023, (Accepted/In press) In: Current biology : CB.

Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation Hau, A., Kelu, J. J., Ochala, J. & Hughes, S., 4 Apr 2023, (Accepted/In press) In: Developmental Biology.

The Spectrum of MORC2-Related Disorders: A Potential Link to Cockayne Syndrome Stafki, S. A., Turner, J., Littel, H. R., Bruels, C. C., Truong, D., Knirsch, U., Stettner, G. M., Graf, U., Berger, W., Kinali, M., Jungbluth, H., Pacak, C. A., Hughes, J., Mirchi, A., Derksen, A., Vincent-Delorme, C., Theil, A. F., Bernard, G., Ellis, D., Fassihi, H., & 4 others, Apr 2023, In: Pediatric neurology. 141, p. 79-86

Discovery of Novel Cardiac Troponin Activators using Fluorescence Polarization-based High Throughput Screening Assays Parijat, P., Ponnam, S., Attili, S., Campbell, K., El-Mezgueldi, M., Pfuhl, M. & Kampourakis, T., 28 Mar 2023, (Accepted/In press) In: Scientific Reports.

Antibody conjugates for targeted delivery of toll-like receptor 9 agonist to the tumor tissue Corogeanu, D., Zaki, K., Beavil, A., Arnold, J. & Diebold, S. S., 13 Mar 2023, In: PLoS One. 18, 3 March, e0282831.

Lis1-dynein drives corona compaction and limits erroneous microtubule attachment at kinetochores Mitevska, O., Lam, P. W., Daly, L. & Auckland, P., 1 Mar 2023, In: Journal of cell science. 136, 5

Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability Ibarra Moreno, C. A., Kraeva, N., Zvaritch, E., Jungbluth, H., Voermans, N. C. & Riazi, S., 1 Mar 2023, In: Anesthesia and Analgesia. 136, 3, p. 569-577

In situ FRET-based localization of the N-terminus of myosin binding protein-C in heart muscle cells Chandler, J., Treacy, C., Ameer-Beg, S., Ehler, E., Irving, M. & Kampourakis, T., 15 Feb 2023, In: Proceedings of the National Academy of Sciences of the United States of America.

Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression Chee, F. L. M., Beernaert, B., Griffith, B. G. C., Loftus, A. E. P., Kumar, Y., Wills, J. C., Lee, M., Valli, J., Wheeler, A. P., Armstrong, J. D., Parsons, M., Leigh, I. M., Proby, C. M., von Kriegsheim, A., Bickmore, W. A., Frame, M. C. & Byron, A., 3 Feb 2023, (Accepted/In press) In: Nature Communications.

Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis Foo, S., Cazenave-Gassiot, A., Wenk, M. & Oliferenko, S., 2 Feb 2023, In: Journal of cell science. 136, 3, jcs260568.

Latent membrane protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma Tang, W. C., Tsao, S. W., Jones, G. E., Liu, X., Tsai, M. H., Delecluse, H. J., Dai, W., You, C., Zhang, J., Huang, S. C. M., Leung, M. M. H., Liu, T., Ching, Y. P., Chen, H., Lo, K. W., Li, X. & Tsang, C. M., Feb 2023, In: Journal of pathology. 259, 2, p. 163-179

Loss of RhoE function in dermatofibroma promotes disorganized dermal fibroblast extracellular matrix and increased integrin activation Endzhievskaya, S., Hsu, C-K., Yang, H-S., Huang, H-Y., Lin, Y-C., Lee, J. Y. W., Onoufriadis, A., Takeichi, T., Lee, J. Y-Y., Shaw, T., McGrath, J. & Parsons, M., 31 Jan 2023, (Accepted/In press) In: Journal of Investigative Dermatology.

The actin-bundling protein Fascin-1 modulates ciliary signalling Brücker, L., Becker, S. K., Maissl, V., Harms, G., Parsons, M. & May-Simera, H. L., 25 Jan 2023, (Accepted/In press) In: Journal of Molecular Cell Biology.

Structure determination of protein-ligand complexes at room temperature using X-ray diffraction approaches Hough, M. A. A., Prischi, F. & Worrall, J. A. R., 23 Jan 2023, In: Frontiers in Molecular Biosciences. 10

A method for reproducible high-resolution imaging of 3D cancer cell spheroids Phillips, T., Caprettini, V., Aggarwal, N., Marcotti, S., Tetley, R., Mao, Y., Shaw, T., Chiappini, C., Parsons, M. & Cox, S., 13 Jan 2023, (E-pub ahead of print) In: Journal of Microscopy.

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan Correia-Melo, C., Kamrad, S., Tengölics, R., Messner, C. B., Trebulle, P., Townsend, S. J., Jayasree Varma, S., Freiwald, A., Heineike, B. M., Campbell, K., Herrera-Dominguez, L., Kaur Aulakh, S., Szyrwiel, L., Yu, J. S. L., Zelezniak, A., Demichev, V., Mülleder, M., Papp, B., Alam, M. T. & Ralser, M., 5 Jan 2023, In: Cell. 186, 1, p. 63-79.e21

Comorbidities of Keloid and Hypertrophic Scars Among Participants in UK Biobank: Comorbidities of excessive scarring Ung, C. Y., Warwick, A. N., Onoufriadis, A., Barker, J., Parsons, M., McGrath, J., Shaw, T. & Dand, N., 4 Jan 2023, In: JAMA dermatology. 159, 2, p. 172-181

Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells Barbera, S., Raucci, L., Tassone, G., Tinti, L., Prischi, F., Santucci, A., Mongiat, M., Tosi, G. M., Galvagni, F., Dimberg, A., Pozzi, C. & Orlandini, M., 1 Jan 2023, In: International Journal of Biological Macromolecules. 224, p. 453-464

Structure-function studies can improve binding affinity of cohesin-dockerin interactions for multi-protein assemblies Duarte, M., Alves, V. D., Correia, M., Caseiro, C., Ferreira, L. M. A., Romão, M. J., Carvalho, A. L., Najmudin, S., Bayer, E. A., Fontes, C. M. G. A. & Bule, P., 1 Jan 2023, In: International Journal of Biological Macromolecules. 224, p. 55-67

Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator Cai, F., Kampourakis, T., Parijat, P., Cockburn, K. T. & Sykes, B. D., 2023, (Accepted/In press) In: Acs Medicinal Chemistry Letters.

Metabolic rewiring in MYC-driven medulloblastoma by BET-bromodomain inhibition Conte, M. R., Dec 2023, In: Scientific Reports. 13, 1, 1273.

Myonuclear alterations associated with exercise are independent of age in humans Battey, E., Ross, J. A., Hoang, A., Wilson, D. G. S., Han, Y., Levy, Y., Pollock, R. D., Kalakoutis, M., Pugh, J. N., Close, G. L., Ellison-Hughes, G. M., Lazarus, N. R., Iskratsch, T., Harridge, S. D. R., Ochala, J. & Stroud, M. J., 2023, (Accepted/In press) In: Journal of Physiology.