View our latest research outputs in full on our Pure page.

Recent publications include:

Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking Swan, A. H., Schindler, R. F. R., Savarese, M., Mayer, I., Rinné, S., Bleser, F., Schänzer, A., Hahn, A., Sabatelli, M., Perna, F., Chapman, K., Pfuhl, M., Spivey, A. C., Decher, N., Udd, B., Tasca, G. & Brand, T., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 4.

GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration Dobson, L., Barrell, W., Seraj, Z., Lynham, S., Wu, S-Y., Krause, M. & Liu, K., 10 Aug 2023, (Accepted/In press) In: Cell Reports.

Visualising Varnish Removal for Conservation of Paintings by Fluorescence Lifetime Imaging (FLIM) Wilda, C., Burnstock, A., Della Rocca, F. M., Henderson, R., Nedbal, J. & Suhling, K., 16 Jun 2023, In: Heritage Science. 37 p., 127.

Optimisation of energy production and central carbon metabolism in a non-respiring eukaryote Alam, S., Gu, Y., Reichert, P., Bähler, J. & Oliferenko, S., 5 Jun 2023, In: Current biology : CB. 33, 11, p. 2175-2186.e5

Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity Davies, A. M., Beavil, R., Barbolov, M., Sandhar, B., Gould, H., Beavil, A., Sutton, B. & McDonnell, J., 1 Jun 2023, In: Molecular Immunology. 159, p. 28-37 10 p.

Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism Brunello, E., Marcucci, L., Irving, M. & Fusi, L., 22 May 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22

Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles Trampari, E., Prischi, F., Vargiu, A. V., Abi-Assaf, J., Bavro, V. N. & Webber, M. A., 10 May 2023, In: npj Antimicrobials and Resistance. 1, 2.

IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action McDonnell, J., Sutton, B. & Gould, H., 26 Apr 2023, In: Annual Review of Immunology. 41, p. 255-275 21 p.

Anti-cancer Pro-inflammatory Effects of an IgE Antibody Targeting the Melanoma-associated Antigen Chondroitin Sulfate Proteoglycan 4 Chauhan, J., Grandits, M., Gusmao Ferreira, L. C., Mele, S., Nakamura, M., Lopez-Abente Muroz, J., Crescioli, S., Laddach, R., Romero Clavijo, P., Cheung, A., Stavraka, C., Chenoweth, A., Sow, H. S., Chiaruttini, G., Gilbert, A., Dodev, T., Koers, A., Pellizzari, G., Ilieva, K., Man, F., & 20 others, 25 Apr 2023, In: Nature Communications. 14, 1, 2192.

Extracellular matrix assembly stress initiates Drosophila central nervous system morphogenesis Serna Morales, E., Sánchez Sánchez, B., Marcotti, S., Nichols, A., Bhargava, A., Dragu, A., Hirvonen, L., Díaz-de-la-Loza, M-C., Mink, M., Cox, S., Rayfield, E., Lee, R. M., Hobson, C. M., Chew, T-L. & Stramer, B., 21 Apr 2023, In: Developmental Cell.

Optimisation of energy production and central carbon metabolism in a non-respiring eukaryote Alam, S., Gu, Y., Reichert, P., Bähler, J. & Oliferenko, S., 18 Apr 2023, (Accepted/In press) In: Current biology : CB.

Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator Cai, F., Kampourakis, T., Parijat, P., Cockburn, K. T. & Sykes, B. D., 13 Apr 2023, (Accepted/In press) In: Acs Medicinal Chemistry Letters.

Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation Hau, A., Kelu, J. J., Ochala, J. & Hughes, S., 4 Apr 2023, (Accepted/In press) In: Developmental Biology.

The Spectrum of MORC2-Related Disorders: A Potential Link to Cockayne Syndrome Stafki, S. A., Turner, J., Littel, H. R., Bruels, C. C., Truong, D., Knirsch, U., Stettner, G. M., Graf, U., Berger, W., Kinali, M., Jungbluth, H., Pacak, C. A., Hughes, J., Mirchi, A., Derksen, A., Vincent-Delorme, C., Theil, A. F., Bernard, G., Ellis, D., Fassihi, H., & 4 others, Apr 2023, In: Pediatric neurology. 141, p. 79-86

Discovery of Novel Cardiac Troponin Activators using Fluorescence Polarization-based High Throughput Screening Assays Parijat, P., Ponnam, S., Attili, S., Campbell, K., El-Mezgueldi, M., Pfuhl, M. & Kampourakis, T., 28 Mar 2023, (Accepted/In press) In: Scientific Reports.

In situ FRET-based localization of the N-terminus of myosin binding protein-C in heart muscle cells Chandler, J., Treacy, C., Ameer-Beg, S., Ehler, E., Irving, M. & Kampourakis, T., 21 Mar 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 12, e2222005120.

Antibody conjugates for targeted delivery of toll-like receptor 9 agonist to the tumor tissue Corogeanu, D., Zaki, K., Beavil, A., Arnold, J. & Diebold, S. S., 13 Mar 2023, In: PLoS One. 18, 3 March, e0282831.

Lis1-dynein drives corona compaction and limits erroneous microtubule attachment at kinetochores Mitevska, O., Lam, P. W., Daly, L. & Auckland, P., 1 Mar 2023, In: Journal of cell science. 136, 5

Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability Ibarra Moreno, C. A., Kraeva, N., Zvaritch, E., Jungbluth, H., Voermans, N. C. & Riazi, S., 1 Mar 2023, In: Anesthesia and Analgesia. 136, 3, p. 569-577

A gene regulatory network for neural induction Trevers, K. E., Lu, H. C., Yang, Y., Thiery, A. P., Strobl, A. C., Anderson, C., Pálinkášová, B., de Oliveira, N. M. M., de Almeida, I. M., Khan, M. A. F., Moncaut, N., Luscombe, N. M., Dale, L., Streit, A. & Stern, C. D., Mar 2023, In: eLife. 12, e73189.

In situ FRET-based localization of the N-terminus of myosin binding protein-C in heart muscle cells Chandler, J., Treacy, C., Ameer-Beg, S., Ehler, E., Irving, M. & Kampourakis, T., 15 Feb 2023, In: Proceedings of the National Academy of Sciences of the United States of America.

Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression Chee, F. L. M., Beernaert, B., Griffith, B. G. C., Loftus, A. E. P., Kumar, Y., Wills, J. C., Lee, M., Valli, J., Wheeler, A. P., Armstrong, J. D., Parsons, M., Leigh, I. M., Proby, C. M., von Kriegsheim, A., Bickmore, W. A., Frame, M. C. & Byron, A., 3 Feb 2023, (Accepted/In press) In: Nature Communications.

Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis Foo, S., Cazenave-Gassiot, A., Wenk, M. & Oliferenko, S., 2 Feb 2023, In: Journal of cell science. 136, 3, jcs260568.

Latent membrane protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma Tang, W. C., Tsao, S. W., Jones, G. E., Liu, X., Tsai, M. H., Delecluse, H. J., Dai, W., You, C., Zhang, J., Huang, S. C. M., Leung, M. M. H., Liu, T., Ching, Y. P., Chen, H., Lo, K. W., Li, X. & Tsang, C. M., Feb 2023, In: Journal of pathology. 259, 2, p. 163-179

Loss of RhoE function in dermatofibroma promotes disorganized dermal fibroblast extracellular matrix and increased integrin activation Endzhievskaya, S., Hsu, C-K., Yang, H-S., Huang, H-Y., Lin, Y-C., Lee, J. Y. W., Onoufriadis, A., Takeichi, T., Lee, J. Y-Y., Shaw, T., McGrath, J. & Parsons, M., 31 Jan 2023, (Accepted/In press) In: Journal of Investigative Dermatology.

The actin-bundling protein Fascin-1 modulates ciliary signalling Brücker, L., Becker, S. K., Maissl, V., Harms, G., Parsons, M. & May-Simera, H. L., 25 Jan 2023, (Accepted/In press) In: Journal of Molecular Cell Biology.