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01 May 2024

Latest publications from the Randall

Take a look at the latest publications from the Randall Centre for Cell & Molecular Biophysics

Research Lab

View our latest research outputs in full on our Pure page.

Recent publications include:

Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers. Singh, A., Singh, V., Wallis, N., Abis, G., Oberman, F., Wood, T., Dhamdhere, M., Gershon, T., Ramos, A., K. Yisraeli, J., S. Spiegelman, V. & K. Sharma, A., 5 Jan 2024, In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 263

in-silico and in-vitro analysis of IL36RN mutations reveals critical residues for the function of the interleukin-36 receptor complex. Hassi, N. K.Weston, T., Rinaldi, G., Ng, J. C., Smahi, A., Twelves, S., Davan-Wetton, C., Fakhreddine, D.Fraternali, F. & Capon, F., Dec 2023, In: Journal of Investigative Dermatology. 143, 12, p. 2468-2475.e6

IFN-γ-dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis. Muñoz-Ruiz, M., Llorian, M., D'Antuono, R., Pavlova, A., Mavrigiannaki, A. M., McKenzie, D., García-Cassani, B., Iannitto, M. L.Wu, Y.Dart, R.Davies, D., Jamal-Hanjani, M., Jandke, A.Ushakov, D. S. & Hayday, A. C., Dec 2023, In: Journal of Allergy and Clinical Immunology. 152, 6, p. 1520-1540 21 p.

Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery. for the FLO-ELA investigators, Forbes, G., Phillips, R., Clark, A., Carter, M., Green, J.Lee, J., Olive, R., Harris, J.Ward, C.Adams, L., Hansen, T., Potter, C.Sampson, J., Sutton, P., Smith, R.Smith, C.Smith, S.Harris, S.Ali, T.& 37 others, Dec 2023, In: Trials. 24, 1, 313.

Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking. Swan, A. H., Schindler, R. F. R., Savarese, M., Mayer, I., Rinné, S., Bleser, F., Schänzer, A., Hahn, A., Sabatelli, M., Perna, F., Chapman, K., Pfuhl, M., Spivey, A. C., Decher, N., Udd, B., Tasca, G. & Brand, T., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 4.

Imaging actin organisation and dynamics in 3D. Phillips, T.Marcotti, S.Cox, S. & Parsons, M., 6 Dec 2023, (Accepted/In press) In: Journal of Cell Science.

Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle. Caremani, M., Fusi, L., Reconditi, M., Piazzesi, G., Narayanan, T., Irving, M., Lombardi, V., Linari, M. & Brunello, E., 4 Dec 2023, In: Journal of General Physiology. 155, 12

Autocrine IL-6 drives cell and extracellular matrix anisotropy in scar fibroblasts. Kenny, F.Marcotti, S.Belo De Freitas, D.Drudi, E., Leech, V., Bell, R.Easton, J., Díaz-de-la-Loza, M-C., Fleck, R., Allison, L.Philippeos, C., Manhart, A., Shaw, T. & Stramer, B., Nov 2023, In: Matrix Biology. 123, p. 1-16 16 p.

Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion. Jahin, I.Phillips, T.Marcotti, S.Gorey, M.Cox, S. & Parsons, M., 21 Nov 2023, (Accepted/In press) In: Frontiers in Cell and Developmental Biology.

Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening. Parijat, P.Attili, S.Hoare, Z.Shattock, M., Kenyon, V. & Kampourakis, T., 13 Nov 2023, In: Nature Communications.

Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation. Knight, H.Abis, G.Kaur, M.Green, H., Krasemann, S., Hartmann, K., Lynham, S.Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R., Eaton, P. & Rudyk, O., 2 Nov 2023, (Accepted/In press) In: Circulation Research. 133

Interaction of amisulpride with GLUT1 at the blood-brain barrier. Relevance to Alzheimer's disease. Boyanova, S. T.Lloyd-Morris, E.Corpe, C.Rahman, K. M., Farag, D. B., Page, L. K., Wang, H.Fleckney, A. L.Gatt, A.Troakes, C.Vizcay-Barrena, G.Fleck, R., Reeves, S. J. & Thomas, S. A., 16 Aug 2023, In: PLoS ONE. 18, 10 Oct, p. e0286278 e0286278.

Gene therapy for spinal muscular atrophy. Gowda, V. L., Jungbluth, H. & Wraige, E., 1 Oct 2023, In: Archives of Disease in Childhood: Education and Practice Edition. 108, 5, p. 347-350 4 p., archdischild-2023-325359.

Editorial: Weak interactions in molecular machinery volume II. Corrales-Guerrero, L., Prischi, F. & Díaz-Moreno, I., 15 Sept 2023, In: Frontiers in Molecular Biosciences. 10, 1284353.

Bridging imaging users to imaging analysis – A community survey. Sivagurunathan, S., Marcotti, S., Nelson, C. J., Jones, M. L., Barry, D. J., Slater, T. J. A., Eliceiri, K. W. & Cimini, B. A., 13 Sept 2023, In: Journal of Microscopy.

Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers. Abis, G., Nicastro, G., Klein, P., Esteban-Serna, S., Gallagher, C., Chaves-Arquero, B., Cai, S., Figueiredo, A. M., Martin, S. R., Taylor, I. A. & Ramos, A., 8 Sept 2023, In: Nucleic Acids Research. 51, 16, p. 8774-8786 13 p.

Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Lechertier, T., Reynolds, L. E., Kim, H., Pedrosa, A. R., Gómez-Escudero, J., Muñoz-Félix, J. M., Batista, S., Dukinfield, M., Demircioglu, F., Wong, P. P., Matchett, K. P., Henderson, N. C., D’Amico, G., Parsons, M., Harwood, C., Meier, P. & Hodivala-Dilke, K. M., 6 Sept 2023, In: Nature Communications. 14, 1, 5446.

Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking Swan, A. H., Schindler, R. F. R., Savarese, M., Mayer, I., Rinné, S., Bleser, F., Schänzer, A., Hahn, A., Sabatelli, M., Perna, F., Chapman, K., Pfuhl, M., Spivey, A. C., Decher, N., Udd, B., Tasca, G. & Brand, T., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 4.

GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration Dobson, L.Barrell, W., Seraj, Z., Lynham, S.Wu, S-Y.Krause, M. & Liu, K., 10 Aug 2023, (Accepted/In press) In: Cell Reports.

Visualising Varnish Removal for Conservation of Paintings by Fluorescence Lifetime Imaging (FLIM) Wilda, C., Burnstock, A., Della Rocca, F. M., Henderson, R., Nedbal, J. & Suhling, K., 16 Jun 2023, In: Heritage Science. 37 p., 127.

Optimisation of energy production and central carbon metabolism in a non-respiring eukaryote Alam, S.Gu, Y., Reichert, P., Bähler, J. & Oliferenko, S., 5 Jun 2023, In: Current biology : CB. 33, 11, p. 2175-2186.e5

Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity Davies, A. M.Beavil, R.Barbolov, M.Sandhar, B.Gould, H.Beavil, A.Sutton, B. & McDonnell, J., 1 Jun 2023, In: Molecular Immunology. 159, p. 28-37 10 p.

Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism Brunello, E., Marcucci, L., Irving, M. & Fusi, L., 22 May 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22

Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles Trampari, E., Prischi, F., Vargiu, A. V., Abi-Assaf, J., Bavro, V. N. & Webber, M. A., 10 May 2023, In: npj Antimicrobials and Resistance. 1, 2.

IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action McDonnell, J.Sutton, B. & Gould, H., 26 Apr 2023, In: Annual Review of Immunology. 41, p. 255-275 21 p.