
Biography
Adam is currently a lecturer whose research focusses on the interactions of biomaterials with the immune system. Adam obtained a PhD in Vaccinology from University of Surrey under the supervision of Dr Simon Graham and Prof. Graham Stewart. This research was on development of particulate based systems as novel immune adjuvants as well as delivery vehicles for vaccines. He then worked at Imperial College London, Department of Mucosal Immunology under Dr John Tregoning in partnership with an industrial collaborator. The project was looking at novel DNA vaccine formulations for induction of humoral and cellular immune responses in numerous models. Following this Adam had a 5-year stint as a Research Associate at the Jenner Institute, University of Oxford, investigating controlled delivery of antigen for induction of spatially and temporally restricted immune responses, primarily for malaria working with Dr Anita Milicic and Prof. Adrian Hill. Joining Professor Khuloud Al-Jamal’s team at KCL, Adam moved from infectious disease to the assessment of nanostructures for use in prophylactic and therapeutic cancer treatments. Adam was awarded the prestigious Maplethorpe fellowship (2019-2022) to work on particulate formulations for nucleic acid delivery to tumours. He continued this work at AstraZeneca (2022-2024) but has now returned to King’s College London to take up his current role.
Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent
Liam-Or, R., Faruqu, F. N., Walters, A., Han, S., Xu, L., Wang, J. T. W., Oberlaender, J., Sanchez-Fueyo, A., Lombardi, G., Dazzi, F., Mailaender, V. & Al-Jamal, K. T., Jun 2024, In: Nature Nanotechnology. 19, 6, p. 846-855 10 p.Research output: Contribution to journal › Article › peer-review
Plasmid DNA ionisable lipid nanoparticles as non-inert carriers and potent immune activators for cancer immunotherapy
Qin, Y., Rouatbi, N., Wang, J. T. W., Baker, R., Spicer, J., Walters, A. A. & Al-Jamal, K. T., May 2024, In: Journal of Controlled Release. 369, p. 251-265 15 p.Research output: Contribution to journal › Article › peer-review
Anti-tumor antibody isotype response can be modified with locally administered immunoadjuvants
Walters, A. A., Ali, A., Wang, J. T. W. & Al-Jamal, K. T., Jul 2023, In: Drug Delivery and Translational Research. 13, 7, p. 2032-2040 9 p.Research output: Contribution to journal › Article › peer-review
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Qin, Y., Walters, A. A., Rouatbi, N., Wang, J. T. W., Abdel-Bar, H. M. & Al-Jamal, K. T., Aug 2023, In: Biomaterials. 299, 122158.Research output: Contribution to journal › Article › peer-review
Investigating the Potential of Cuboidal Nanometals as Protein Subunit Vaccine Carriers In Vivo
Yavuz, E., Walters, A. A., Chudasama, B. V., Han, S., Qin, Y. & Al-Jamal, K. T., 13 Oct 2023, In: advanced materials interfaces. 10, 29, 2202511.Research output: Contribution to journal › Article › peer-review
Plasmid DNA cationic non-viral vector complexes induce cytotoxicity-associated PD-L1 expression up-regulation in cancer cells in vitro
Qin, Y., Walters, A. A. & Al-Jamal, K. T., 25 Jan 2023, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 631, 122481.Research output: Contribution to journal › Article › peer-review
A natural protein based platform for the delivery of Temozolomide acid to glioma cells
Helal, D. O., Rouatbi, N., Han, S., Tzu-Wen Wang, J., Walters, A. A., Abdel-Mottaleb, M. M. A., Kamel, A. O., Geneidi, A. S., Awad, G. A. S. & Al-Jamal, K. T., Dec 2021, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 169, p. 297-308 12 p.Research output: Contribution to journal › Article › peer-review
An “eat me” combinatory nano-formulation for systemic immunotherapy of solid tumors
Abdel-Bar, H. M., Walters, A. A., Lim, Y., Rouatbi, N., Qin, Y., Gheidari, F., Han, S., Osman, R., Wang, J. T. W. & Al-Jamal, K. T., 2021, In: Theranostics. 11, 18, p. 8738-8754 17 p.Research output: Contribution to journal › Article › peer-review
Combinatory Delivery of Etoposide and siCD47 in a Lipid Polymer Hybrid Delays Lung Tumor Growth in an Experimental Melanoma Lung Metastatic Model
Abdel-Bar, H. M., Walters, A. A., Wang, J. T. W. & Al-Jamal, K. T., 7 Apr 2021, In: Advanced Healthcare Materials. 10, 7, 2001853.Research output: Contribution to journal › Article › peer-review
Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment
Xu, L., Faruqu, F. N., Lim, Y. M., Lim, K. Y., Liam-Or, R., Walters, A. A., Lavender, P., Fear, D., Wells, C. M., Tzu-Wen Wang, J. & Al-Jamal, K. T., Jan 2021, In: Biomaterials. 264, 120369.Research output: Contribution to journal › Article › peer-review
Modulating expression of inhibitory and stimulatory immune ‘checkpoints’ using nanoparticulate-assisted nucleic acid delivery
Walters, A. A., Dhadwar, B. & Al-Jamal, K. T., Nov 2021, In: EBioMedicine. 73, 103624.Research output: Contribution to journal › Article › peer-review
Nanoparticle Mediated In Situ Molecular Reprogramming of Immune Checkpoint Interactions for Cancer Immunotherapy
Walters, A., Santacana-Font, G., Li, J., Rouatbi, N., Qin, Y., Claes, N., Bals, S., Wang, J. & Al-Jamal, K., 2 Sept 2021, (Accepted/In press) In: ACS Nano.Research output: Contribution to journal › Article › peer-review
Nucleic acid-based immune checkpoint blockade: Progress and potential
Walters, A. A., Dhadwar, B. & Al-Jamal, K. T., 1 Jan 2021, Systemic Drug Delivery Strategies: Volume 2 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy. Elsevier, p. 273-293 21 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Tailoring the Architecture of Cationic Polymer Brush-Modified Carbon Nanotubes for Efficient siRNA Delivery in Cancer Immunotherapy
Li, D., Ahmed, M., Khan, A., Xu, L., Walters, A. A., Ballesteros, B. & Al-Jamal, K. T., 7 Jul 2021, In: ACS Applied Materials and Interfaces. 13, 26, p. 30284-30294 11 p.Research output: Contribution to journal › Article › peer-review
Evaluation of cell surface reactive immuno-adjuvant in combination with immunogenic cell death inducing drug for in situ chemo-immunotherapy
Walters, A. A., Wang, J. T. W. & Al-Jamal, K. T., 10 Jun 2020, In: Journal of Controlled Release. 322, p. 519-529 11 p.Research output: Contribution to journal › Article › peer-review
Green synthesis of methoxy-poly(ethylene glycol)-block-poly(L-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo
Giram, P. S., Wang, J.T.-W., Walters, A. A., Rade, P. P., Akhtar, M., Han, S., Faruqu, F. N., Abdel-Bar, H. M., Garnaik, B. & Al-Jamal, K. T., 18 Nov 2020, (E-pub ahead of print) In: Biomaterials Science.Research output: Contribution to journal › Article › peer-review
Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances
Hassan, H. A. F. M., Diebold, S. S., Smyth, L. A., Walters, A. A., Lombardi, G. & Al-Jamal, K. T., 10 Mar 2019, In: Journal of Controlled Release. 297, p. 79-90 12 p.Research output: Contribution to journal › Review article › peer-review
Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines
Mei, K. C., Ghazaryan, A., Teoh, E. Z., Summers, H. D., Li, Y., Ballesteros, B., Piasecka, J., Walters, A., Hider, R. C., Mailänder, V. & Al-Jamal, K. T., 4 Oct 2018, In: Advanced Materials. 30, 40, 1802732.Research output: Contribution to journal › Article › peer-review
Research

Medicines Development
The Medicines Development Research Group develops novel materials, formulations, drug delivery devices, manufacturing, analytical, and digital technologies.
News
Researchers win grant allowing cross-school collaboration to examine if immunogenic cell death can be exploited in brain cancer
New project aims to develop a new treatment option for brain cancer.

Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent
Liam-Or, R., Faruqu, F. N., Walters, A., Han, S., Xu, L., Wang, J. T. W., Oberlaender, J., Sanchez-Fueyo, A., Lombardi, G., Dazzi, F., Mailaender, V. & Al-Jamal, K. T., Jun 2024, In: Nature Nanotechnology. 19, 6, p. 846-855 10 p.Research output: Contribution to journal › Article › peer-review
Plasmid DNA ionisable lipid nanoparticles as non-inert carriers and potent immune activators for cancer immunotherapy
Qin, Y., Rouatbi, N., Wang, J. T. W., Baker, R., Spicer, J., Walters, A. A. & Al-Jamal, K. T., May 2024, In: Journal of Controlled Release. 369, p. 251-265 15 p.Research output: Contribution to journal › Article › peer-review
Anti-tumor antibody isotype response can be modified with locally administered immunoadjuvants
Walters, A. A., Ali, A., Wang, J. T. W. & Al-Jamal, K. T., Jul 2023, In: Drug Delivery and Translational Research. 13, 7, p. 2032-2040 9 p.Research output: Contribution to journal › Article › peer-review
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Qin, Y., Walters, A. A., Rouatbi, N., Wang, J. T. W., Abdel-Bar, H. M. & Al-Jamal, K. T., Aug 2023, In: Biomaterials. 299, 122158.Research output: Contribution to journal › Article › peer-review
Investigating the Potential of Cuboidal Nanometals as Protein Subunit Vaccine Carriers In Vivo
Yavuz, E., Walters, A. A., Chudasama, B. V., Han, S., Qin, Y. & Al-Jamal, K. T., 13 Oct 2023, In: advanced materials interfaces. 10, 29, 2202511.Research output: Contribution to journal › Article › peer-review
Plasmid DNA cationic non-viral vector complexes induce cytotoxicity-associated PD-L1 expression up-regulation in cancer cells in vitro
Qin, Y., Walters, A. A. & Al-Jamal, K. T., 25 Jan 2023, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 631, 122481.Research output: Contribution to journal › Article › peer-review
A natural protein based platform for the delivery of Temozolomide acid to glioma cells
Helal, D. O., Rouatbi, N., Han, S., Tzu-Wen Wang, J., Walters, A. A., Abdel-Mottaleb, M. M. A., Kamel, A. O., Geneidi, A. S., Awad, G. A. S. & Al-Jamal, K. T., Dec 2021, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 169, p. 297-308 12 p.Research output: Contribution to journal › Article › peer-review
An “eat me” combinatory nano-formulation for systemic immunotherapy of solid tumors
Abdel-Bar, H. M., Walters, A. A., Lim, Y., Rouatbi, N., Qin, Y., Gheidari, F., Han, S., Osman, R., Wang, J. T. W. & Al-Jamal, K. T., 2021, In: Theranostics. 11, 18, p. 8738-8754 17 p.Research output: Contribution to journal › Article › peer-review
Combinatory Delivery of Etoposide and siCD47 in a Lipid Polymer Hybrid Delays Lung Tumor Growth in an Experimental Melanoma Lung Metastatic Model
Abdel-Bar, H. M., Walters, A. A., Wang, J. T. W. & Al-Jamal, K. T., 7 Apr 2021, In: Advanced Healthcare Materials. 10, 7, 2001853.Research output: Contribution to journal › Article › peer-review
Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment
Xu, L., Faruqu, F. N., Lim, Y. M., Lim, K. Y., Liam-Or, R., Walters, A. A., Lavender, P., Fear, D., Wells, C. M., Tzu-Wen Wang, J. & Al-Jamal, K. T., Jan 2021, In: Biomaterials. 264, 120369.Research output: Contribution to journal › Article › peer-review
Modulating expression of inhibitory and stimulatory immune ‘checkpoints’ using nanoparticulate-assisted nucleic acid delivery
Walters, A. A., Dhadwar, B. & Al-Jamal, K. T., Nov 2021, In: EBioMedicine. 73, 103624.Research output: Contribution to journal › Article › peer-review
Nanoparticle Mediated In Situ Molecular Reprogramming of Immune Checkpoint Interactions for Cancer Immunotherapy
Walters, A., Santacana-Font, G., Li, J., Rouatbi, N., Qin, Y., Claes, N., Bals, S., Wang, J. & Al-Jamal, K., 2 Sept 2021, (Accepted/In press) In: ACS Nano.Research output: Contribution to journal › Article › peer-review
Nucleic acid-based immune checkpoint blockade: Progress and potential
Walters, A. A., Dhadwar, B. & Al-Jamal, K. T., 1 Jan 2021, Systemic Drug Delivery Strategies: Volume 2 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy. Elsevier, p. 273-293 21 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Tailoring the Architecture of Cationic Polymer Brush-Modified Carbon Nanotubes for Efficient siRNA Delivery in Cancer Immunotherapy
Li, D., Ahmed, M., Khan, A., Xu, L., Walters, A. A., Ballesteros, B. & Al-Jamal, K. T., 7 Jul 2021, In: ACS Applied Materials and Interfaces. 13, 26, p. 30284-30294 11 p.Research output: Contribution to journal › Article › peer-review
Evaluation of cell surface reactive immuno-adjuvant in combination with immunogenic cell death inducing drug for in situ chemo-immunotherapy
Walters, A. A., Wang, J. T. W. & Al-Jamal, K. T., 10 Jun 2020, In: Journal of Controlled Release. 322, p. 519-529 11 p.Research output: Contribution to journal › Article › peer-review
Green synthesis of methoxy-poly(ethylene glycol)-block-poly(L-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo
Giram, P. S., Wang, J.T.-W., Walters, A. A., Rade, P. P., Akhtar, M., Han, S., Faruqu, F. N., Abdel-Bar, H. M., Garnaik, B. & Al-Jamal, K. T., 18 Nov 2020, (E-pub ahead of print) In: Biomaterials Science.Research output: Contribution to journal › Article › peer-review
Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances
Hassan, H. A. F. M., Diebold, S. S., Smyth, L. A., Walters, A. A., Lombardi, G. & Al-Jamal, K. T., 10 Mar 2019, In: Journal of Controlled Release. 297, p. 79-90 12 p.Research output: Contribution to journal › Review article › peer-review
Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines
Mei, K. C., Ghazaryan, A., Teoh, E. Z., Summers, H. D., Li, Y., Ballesteros, B., Piasecka, J., Walters, A., Hider, R. C., Mailänder, V. & Al-Jamal, K. T., 4 Oct 2018, In: Advanced Materials. 30, 40, 1802732.Research output: Contribution to journal › Article › peer-review
Research

Medicines Development
The Medicines Development Research Group develops novel materials, formulations, drug delivery devices, manufacturing, analytical, and digital technologies.
News
Researchers win grant allowing cross-school collaboration to examine if immunogenic cell death can be exploited in brain cancer
New project aims to develop a new treatment option for brain cancer.
