Dr Alessio Delogu PhD

Biography

My lab investigates the development and function of diverse classes of inhibitory neurons in subcortical brain structures, with emphasis on the thalamus. The thalamus plays a central role in sensory perception, attention and the sleep-wake cycle, and its dysfunction contributes to several psychiatric disorders. Our experimental approach relies on the combined application of functional neuroanatomy, genetics and behavioural tests to ultimately understand the role of inhibitory neurons in health and disease.

Please see my Research Staff Profile for more detail

Key publications:

• Huisman et al., 2019. Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators. Nature Communications.
• Jager et al., 2019. Inhibitory interneurons distribute widely across the mouse thalamus and form ontogenetic spatial clusters. BiorXiv.
• Mayer et al., 2019. The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex. Development.
• Jager et al., 2016. Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nature Communications.
• Delogu et al., 2012. Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron.

Key collaborators:

• Professor Stephen Brickley, Imperial College London
• Dr Tomomi Shimogori, RIKEN Institute
• Dr Samuel Cooke, King's College London
• Dr Phil Holland, King's College London