Skip to main content
Alessio Vagnoni

Dr Alessio Vagnoni PhD

Lecturer

  • Lecturer in Cellular Neuroscience

Research interests

  • Ageing
  • Neuroscience

Biography

My research group focuses on the cell biology of the neuron during ageing and neurodegeneration, with particular emphasis on the intricate relationship between intracellular trafficking and neuronal function. The lab is particularly fascinated by the transport of organelles and vesicles in the axons of neurons and our aim is to understand how regulatory nodes of this process can affect neuronal homeostasis during ageing. With time, we have also developed a strong interest in understanding how neuronal trafficking is spatially regulated within cells. Our belief is that a better understanding of the spatio-temporal regulation of neuronal trafficking is crucial to dissect the mechanisms leading to ageing and neurodegeneration. We are currently combining in vivo approaches in Drosophila melanogaster with studies in cultured mammalian neurons and Drosophila cells.

Please see my Research Staff Profile for more detail.

Find out more about my research:

Key Collaborators:

  • Professor Giampietro Schiavo, University College London & Dementia Research Institute
  • Prof Deepak Srivastava and Dr George Chennell, Wohl Cellular Imaging Centre
  • Professor Klaus Suhling, King's College London
  • Dr Tito Calì, University of Padova.

News

Breakthrough in cell aging could show early warning signs for neurodegenerative diseases

A new discovery in how neurons age could help us understand how neurodegenerative ailments like ALS and Alzheimer’s disease (AD) work, and how they’re...

Alessio thumbnail (1)

Dr Francesca Mattedi receives the 2022 Tadion Rideal Prize

The prize recognises her doctoral thesis titled "Optogenetic approaches to study mitochondrial dynamics and function: implications for neuronal ageing"

F.-Mattedi-scaled

£1.3 million MRC grant awarded to study neuronal signalling failure

The Medical Research Council (MRC) has awarded £1,310,130 to King's researchers for the project 'Structural and functional studies of the VAPB-PTPIP51...

Chris Miller ER-mitochondria MRC Grant

Two Neuroscience researchers awarded prestigious NC3Rs PhD studentships incorporating replacement, refinement, and reduction of the use of animals

Professor Robert Hindges’ project 'Zebrafish models of Major Depressive Disorder as a replacement for rodent models' and Dr Alessio Vagnoni’s 'Mapping...

Neuron activity

Dr Alessio Vagnoni receives Leverhulme Trust Research Project Grant

This grant supports his work to investigate the consequences of mitochondrial defects in neuronal dysfunction in ageing.

Illustration of mitochondria

News

Breakthrough in cell aging could show early warning signs for neurodegenerative diseases

A new discovery in how neurons age could help us understand how neurodegenerative ailments like ALS and Alzheimer’s disease (AD) work, and how they’re...

Alessio thumbnail (1)

Dr Francesca Mattedi receives the 2022 Tadion Rideal Prize

The prize recognises her doctoral thesis titled "Optogenetic approaches to study mitochondrial dynamics and function: implications for neuronal ageing"

F.-Mattedi-scaled

£1.3 million MRC grant awarded to study neuronal signalling failure

The Medical Research Council (MRC) has awarded £1,310,130 to King's researchers for the project 'Structural and functional studies of the VAPB-PTPIP51...

Chris Miller ER-mitochondria MRC Grant

Two Neuroscience researchers awarded prestigious NC3Rs PhD studentships incorporating replacement, refinement, and reduction of the use of animals

Professor Robert Hindges’ project 'Zebrafish models of Major Depressive Disorder as a replacement for rodent models' and Dr Alessio Vagnoni’s 'Mapping...

Neuron activity

Dr Alessio Vagnoni receives Leverhulme Trust Research Project Grant

This grant supports his work to investigate the consequences of mitochondrial defects in neuronal dysfunction in ageing.

Illustration of mitochondria