Professor Anthony Dorling Professor Anthony Dorling Academics Supervisors Professor of Transplant Inflammation and Repair Co-Director of Nephrology, Urology & Transplantation. Research subject areas Immunology Contact details anthony.dorling@kcl.ac.uk +44 (0) 20 7188 5880
Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival Peng, Q., Nowocin, A., Ratnasothy, K., Smith, R. A., Smyth, L. A., Lechler, R. I., Dorling, A. & Lombardi, G., 30 Jan 2023, In: Frontiers in Immunology. 13, 980462, p. 980462 980462. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2022.980462 Highly sensitised individuals present a distinct Tregs signature compared to unsensitised individuals on hemodialysis Dudreuilh, C., Basu, S., Shaw, O., Burton, H., Mamode, N., Petrov, N., Barberio, M. T., Lombardi, G., Scotta, C. & Dorling, A., Feb 2023, In: Frontiers. Research output: Contribution to journal › Article A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas Karunanithy, N., Robinson, E. J., Ahmad, F., Burton, J. O., Calder, F., Coles, S., Das, N., Dorling, A., Forman, C., Jaffer, O., Lawman, S., Lakshminarayan, R., Lewlellyn, R., Peacock, J. L., Ramnarine, R., Mesa, I. R., Shaikh, S., Simpson, J., Steiner, K., Suckling, R., & 8 othersSzabo, L., Turner, D., Wadoodi, A., Wang, Y., Weir, G., Wilkins, C. J., Gardner, L. M. & Robson, M. G., Aug 2021, In: Kidney International. 100, 2, p. 447-456 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2021.02.040 Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trial Stringer, D., Gardner, L., Shaw, O., Clarke, B., Briggs, D., Worthington, J., Buckland, M., Danzi, G., Hilton, R., Picton, M., Thuraisingham, R. C., Borrows, R., Baker, R. J., McCullough, K., Stoves, J., Phanish, M. K., Shiu, K. Y., Walsh, S. B., Ahmed, A., Ayub, W., & 12 othersHegarty, J., Tinch-Taylor, R., Georgiou, E., Bidad, N., Kilic, A., Moon, Z., Horne, R., McCrone, P., Kelly, J., Murphy, C., Peacock, J. & Dorling, A., Feb 2023, In: EClinicalMedicine. 56, 101819. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.eclinm.2022.101819 A transitional B cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection Basu, S., Dorling, A. & Chong, A., 20 Mar 2023, (E-pub ahead of print) In: Kidney International. 103, 4, p. 658-660 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2022.12.020 Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusion Chandak, P., Phillips, B. L., Bennett, D., Uwechue, R., Kessaris, N., Shaw, O., Maggs, T., Woodford, L., Veniard, D., Perera, R., Parmar, K., Hunt, B. J., Callaghan, C., Dorling, A. & Mamode, N., Dec 2022, In: EBioMedicine. 86, p. 104365 104365. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.ebiom.2022.104365 Manipulation of Tissue Factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH. Wilkinson, H., Leonard, H., Robson, M., Smith, R., Tam, E., McVey, J. H., Kirchhofer, D., Chen, D. & Dorling, A., 12 Sep 2022, In: Frontiers in immunology. 13, 999871. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2022.999871 The phenotype of HLA-binding B cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-γ production against purified HLA proteins Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., Aug 2022, In: Kidney International. 102, 2, p. 355-369 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2022.02.041 Regulation of T &B cell interactions determines the clinical phenotype associated with donor-specific antibodies Basu, S. & Dorling, A., 20 Apr 2022, In: Kidney International. 101, 5, p. 877-879 3 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2022.02.020 The phenotype of HLA-binding B-cells from sensitised renal transplant recipients correlates with clinically prognostic patterns of IFNγ production against purified HLA proteins Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., 21 Jul 2022, In: Kidney International. 102, 2, p. 355-369 Research output: Contribution to journal › Article › peer-review View all publications
17 January 2023 Optimising immunosuppression based on antibody testing does little to reduce kidney transplant failure rate Treating patients who possess transplant rejecting antibodies, using best available combinations of…