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Professor Anthony Dorling

Academics

Professor of Transplant Inflammation and Repair

Contact details

Biography

Anthony qualified in Medicine from the University of London in 1987 and gained membership of the Royal College of Physicians in 1990 (followed by Fellowship in 2005). He gained his PhD in Immunology from the Royal Postgraduate Medical School in 1996 and finished specialist training in nephrology before being appointed Senior Lecturer (later Reader) in Immunology at Imperial College (Hammersmith Hospital) in 2000. He moved to KCL, with Honorary Consultant status at Guy’s, in 2009. The theme of his research programme is ‘vascular inflammation’, focusing on the cellular and molecular mechanisms involved in vascular rejection. He has shown that coagulation proteases, such as thrombin, play a critical role in inflammatory vascular disease, including rejection and atherosclerosis. These same pathways are also involved in chronic arteriosclerosis and tissue fibrosis. He is co-inventor of a novel therapeutic, called Thrombalexin, that is expected to undergo first in man testing in 2019/20. Clinically, he focuses on patients undergoing antibody-incompatible transplantation and in those with chronic rejection. His translational work has confirmed that B cells play a significant role in processing and presenting donor antigens in these patients, but has revealed a heterogeneous complexity that includes maintenance of tolerance mechanisms in a significant proportion of patients. He is co-PI of the large UK RCT OuTSMART.

Latest publications

C3d positive donor-specific antibodies have a role in pre-transplant risk stratification of crossmatch positive HLA-incompatible renal transplantation: United Kingdom multicentre study
Babu, A., Khovanova, N., Shaw, O., Griffin, S., Briggs, D., Krishnan, N. S., Fletcher, S., Imray, C., Seitz, A., Baker, R., Wellberry-Smith, M., Clarke, B., Cullen, K., Rees, T., Edwards, F., Burrows, E., Howe, L., Martin, C., Dorling, A., Zehnder, D. & 3 others, Higgins, R. M., Mitchell, D. A. & Daga, S., 1 Jun 2020, In : Transplant International. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/tri.13663
B lymphocytes contribute to indirect pathway T cell sensitisation via acquisition of extracellular vesicles
Becker, P. D., Ratnasothy, K., Sen, M., Peng, Q., Romano, M., Bazoer, J., Suvitra, E., Stout, A., Hylton, S. G., Dorling, A., Lechler, R. I., Smyth, L. A. & Lombardi, G., 2 Jun 2020, In : American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/ajt.16088
Regression of atherosclerosis in ApoE-/- mice via modulation of monocyte recruitment and phenotype, induced by weekly dosing of a novel 'cytotopic' anti-thrombin without prolonged anticoagulation.
Chen, D., Li, K., Festenstein, S., Karegli, J., Wilkinson, H., Leonard, H., Wei, L-L., Ma, N., Xia, M., Henry, T., Wang, J. A., Xu, Q., McVey, J. H., Smith, R. & Dorling, A., 22 May 2020, (Accepted/In press) In : Journal of the American Heart Association. Research output: Contribution to journal - Article
Regulatory B cells: Development, phenotypes, functions, and role in transplantation
Alhabbab, R. Y., Nova-Lamperti, E., Aravena, O., Burton, H. M., Lechler, R. I., Dorling, A. & Lombardi, G., 1 Nov 2019, In : Immunological Reviews. 292, 1, p. 164-179 16 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1111/imr.12800
Effect of Optimized Immunosuppression (Including Rituximab) on Anti-Donor Alloresponses in Patients With Chronically Rejecting Renal Allografts: The RituxiCAN-C4 trial
Dorling, A., 5 Feb 2020, In : Frontiers in immunology. 11, 79. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3389/fimmu.2020.00079
Update to the study protocol, including statistical analysis plan, for the multicentre, randomised controlled OuTSMART trial: a combined screening/treatment programme to prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies
Stringer, D., Gardner, L. M., Peacock, J. L., Rebollo-mesa, I., Hilton, R., Shaw, O., Baker, R., Clark, B., Thuraisingham, R. C., Buckland, M., Picton, M., Worthington, J., Borrows, R., Briggs, D., Shah, S., Shiu, K. Y., Mccullough, K., Phanish, M., Hegarty, J., Stoves, J. & 7 others, Ahmed, A., Ayub, W., Horne, R., Mccrone, P., Kelly, J., Murphy, C. & Dorling, A., 5 Aug 2019, In : Trials. 20, 1, 476. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1186/s13063-019-3602-2
Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function
Peng, Q., Ratnasothy, K., Boardman, D. A., Jacob, J., Tung, S. L., Mccluskey, D., Smyth, L. A., Lechler, R. I., Dorling, A. & Lombardi, G., Jun 2019, In : Frontiers in Immunology. 10, JUN, p. 1-14 14 p., 1311. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3389/fimmu.2019.01311
Clinical-pathological Correlations in Post-Transplant Thrombotic Microangiopathy
Broecker, V., Bardsley, V., Torpey, N., Perera, R., Montero, R., Dorling, A., Bentall, A., Neil, D., Willicombe, M., Berry, M. & Roufosse, C., 2019, In : Histopathology. 75, 1, p. 88-103 16 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/his.13855
For the many: permitting deceased donor kidney transplantation across low-titre blood group antibodies can reduce wait times for blood group B recipients, and improve the overall number of 000MM transplants - a multicentre observational cohort study
Manook, M., Mumford, L., Barnett, A. N. R., Osei-Bordom, D., Sandhu, B., Veniard, D., Maggs, T., Shaw, O., Kessaris, N., Dorling, A., Shah, S. & Mamode, N., 14 Dec 2018, In : Transplant International. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/tri.13389
Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury
Lou, J., Hu, Y., Wu, M-D., Che, L-Q., Wu, Y-F., Zhao, Y., Tian, B-P., Bao, Z-Q., Zhu, C., Wu, Y-P., He, L-L., Bai, C-X., Zhou, J., Ying, S-M., Li, W., Chen, Z-H., Chen, D., Dorling, A. & Shen, H-H., 16 Nov 2018, In : ACTA PHARMACOLOGICA SINICA. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41401-018-0175-7

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