Professor Brian Sutton Academics Professor of Molecular Biophysics Contact details brian.sutton@kcl.ac.uk +44 (0) 20 7848 6423
IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE Santos, A., Barbosa-Morais, N. L., Hurlburt, B. K., Ramaswamy, S., Hemmings, O., Kwok, M., O'Rourke, C., Bahnson, H. T., Cheng, H., James, L., Gould, H., Sutton, B. J., Maleki, S. J. & Lack, G., 1 Sep 2020, In : Allergy. 75, 9, p. 2309-2318 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/all.14301 Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization Mitropoulou, A., Ceska, T., Heads, J., Beavil, A., Henry, A. J., McDonnell, J., Sutton, B. & Davies, A. M., 1 Mar 2020, In : Acta Crystallographica Section F:Structural Biology Communications. 76, p. 116-129 14 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1107/S2053230X20001466 Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies Bucaite, G., Kang-Pettinger, T., Moreira, J., Gould, H. J., James, L. K., Sutton, B. J. & McDonnell, J. M., 1 Oct 2019, In : Journal of Immunology. 203, 7, p. 1693-1700 8 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.4049/jimmunol.1900509 Mapping of the binding site for FcμR in human IgM-Fc Nyamboya, R. A., Sutton, B. J. & Calvert, R. A., 23 Aug 2019, In : BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 1868, 1, 140266. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.bbapap.2019.140266 IgE Antibodies: From Structure to Function and Clinical Translation Sutton, B. J., Davies, A. M., Bax, H. J. & Karagiannis, S. N., 22 Feb 2019, In : Antibodies (Basel, Switzerland). 8, 1 Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.3390/antib8010019https://doi.org/10.3390/antib8010019 A mass spectrometry-based modelling workflow for accurate prediction of IgG antibody conformations in the gas phase Hansen, K., Lau, A. M. C., Giles, K., McDonnell, J. M., Struwe, WB., Sutton, B. J. & Politis, A., 21 Dec 2018, In : ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57, 52, p. 17194-17199 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/anie.201812018 The structure of PghL hydrolase bound to its substrate poly-γ-glutamate Ramaswamy, S., Rasheed, M., Morelli, C. F., Calvio, C., Sutton, B. J. & Pastore, A., 2 Nov 2018, In : FEBS Journal. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/febs.14688 Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition Mitropoulou, A. N., Bowen, H., Dodev, T. S., Davies, A. M., Bax, H. J., Beavil, R. L., Beavil, A. J., Gould, H. J., James, L. K. & Sutton, B. J., 11 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8707-E8716 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1073/pnas.1806840115 Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody Chen, J-B., Ramadani, F., Pang, M. O. Y., Beavil, R. L., Holdom, M. D., Mitropoulou, A. N., Beavil, A. J., Gould, H. J., Chang, T. W., Sutton, B. J., McDonnell, J. M. & Davies, A. M., 1 Aug 2018, In : Scientific Reports. 8, 1, 11548. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41598-018-29664-4 Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation Doré, K. A., Kashiwakura, J., McDonnell, J. M., Gould, H. J., Kawakami, T., Sutton, B. J. & Davies, A. M., Jan 2018, In : Molecular Immunology. 93, p. 216-222 7 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.molimm.2017.11.022 View all publications