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King’s People

Professor Christopher Mathew

Emeritus staff

Professor of Molecular Genetics

Contact details

Biography

Chris Mathew is Professor of Molecular Genetics in the Department of Medical and Molecular Genetics in the School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine at Kings College London. He has a joint appointment as Distinguished Professor in Human Genetics in the Faculty of Health Sciences at Witwatersrand University, based at the Sydney Brenner Institute for Molecular Bioscience.

His main research interest is the investigation of genetic factors which contribute to the development of African cancers, and of genomic changes which are driving tumour development. He is a Principal Investigator on two major grants from the Newton Fund to investigate the genetics of common African cancers.

He has published over 260 peer-reviewed articles and has an H-index of 83, with >30,000 citations. His contribution to an increased understanding of the genetics of human disease was recognised by his election as a Fellow of the Academy of Medical Sciences UK in 2001.

Latest publications

Kaposi sarcoma-associated herpesvirus, HIV-1 and Kaposi sarcoma risk in black South Africans diagnosed with cancer during antiretroviral treatment rollout
Motlhale, M., Mathew, C., Lewis, C. & Sitas, F., 15 May 2023, In: International Journal of Cancer. 152, 10, p. 2081-2089 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/doi: 10.1002/ijc.34454
Lifestyle factors associated with sex differences in Kaposi sarcoma incidence among adult black South Africans: A case-control study
Motlhale, M., Sitas, F., Bradshaw, D., Chen, W. C., Singini, M. G., de Villiers, C. B., Lewis, C. M., Muchengeti, M., Waterboer, T., Mathew, C. G., Newton, R. & Singh, E., 30 Jun 2022, In: Cancer Epidemiology. 78, 102158. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.canep.2022.102158
Epidemiology of Kaposi's sarcoma in sub-Saharan Africa
Motlhale, M., Sitas, F., Bradshaw, D., Chen, W. C., Singini, M. G., de Villiers, C. B., Lewis, C. M., Muchengeti, M., Waterboer, T., Mathew, C. G., Newton, R. & Singh, E., Jun 2022, In: Cancer Epidemiology. 78, 102167. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1016/j.canep.2022.102167
Johannesburg Cancer Study (JCS): contribution to knowledge and opportunities arising from 20 years of data collection in an African setting
Chen, W. C., Singh, E., Muchengeti, M., Bradshaw, D., Mathew, C. G., Babb de Villiers, C., Lewis, C. M., Waterboer, T., Newton, R. & Sitas, F., Apr 2020, In: Cancer Epidemiology. 65, 101701. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.canep.2020.101701
IBD BioResource: An Open-Access Platform of 25 000 Patients to Accelerate Research in Crohn's and Colitis
Parkes, M., Prescott, N., Mathew, C., Sanderson, J. & Irving, P., Sep 2019, In: Gut. 68, 9, p. 1537-1540 Research output: Contribution to journal › Letter › peer-review. DOIs: https://doi.org/10.1136/gutjnl-2019-318835
Genetic and Inflammatory Biomarkers Classify Small Intestine Inflammation in Asymptomatic First-degree Relatives of Patients With Crohn's Disease
Taylor, K. M., Hanscombe, K. B., Prescott, N. J., Iniesta, R., Traylor, M., Taylor, N. S., Fong, S., Powell, N., Irving, P. M., Anderson, S. H., Mathew, C. G., Lewis, C. M. & Sanderson, J. D., 14 Jun 2019, (E-pub ahead of print) In: Clinical Gastroenterology and Hepatology : the official clinical practice journal of the American Gastroenterological Association. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.cgh.2019.05.061
Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population
Chen, W. C., Bye, H., Matejcic, M., Amar, A., Govender, D., Khew, Y. W., Beynon, V., Kerr, R., Singh, E., Prescott, N. J., Lewis, C. M., Babb de Villiers, C., Parker, M. I. & Mathew, C. G., Apr 2019, In: Carcinogenesis. 40, 4, p. 513-520 8 p., bgz026. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/carcin/bgz026
The relationship between environmental exposure and genetic architecture of the 2q33 locus with esophageal cancer in South Africa
Matejcic, M., Mathew, C. G. & Iqbal Parker, M., 1 Jan 2019, In: Frontiers in Genetics. 10, MAY, 406. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fgene.2019.00406
Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer
Traylor, M., Walker, J. L., Corrigan, A. A., Hernandez, M. A., Newhouse, S. J., Folarin, A. A., Patel, H., Ross, P. J., Sanderson, J. D., Spicer, J., Prescott, N. J., Mathew, C. G., Marinaki, A. M. & Lewis, C. M., 1 May 2018, In: PLoS ONE. 13, 5, 11 p., e0188911. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pone.0188911
Exome Sequencing and Genotyping Identify a Rare Variant in NLRP7 Gene Associated With Ulcerative Colitis
Onoufriadis, A., Stone, K., Katsiamides, A., Amar, A., Omar, Y., de Lange, K. M., Taylor, K., Barrett, J. C., Pollok, R., Hayee, BH., Mansfield, J. C., Sanderson, J. D., Simpson, M. A., Mathew, C. G. & Prescott, N. J., Mar 2018, In: Journal of Crohn's & colitis. 12, 3, p. 321–326 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1101/182113, https://doi.org/10.1093/ecco-jcc/jjx157

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