Professor Christopher Mathew Emeritus staff Professor of Molecular Genetics Contact details christopher.mathew@kcl.ac.uk +44 (0) 20 7848 8509
Johannesburg Cancer Study (JCS): contribution to knowledge and opportunities arising from 20 years of data collection in an African setting Chen, W. C., Singh, E., Muchengeti, M., Bradshaw, D., Mathew, C. G., Babb de Villiers, C., Lewis, C. M., Waterboer, T., Newton, R. & Sitas, F., Apr 2020, In: Cancer Epidemiology. 65, 101701. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.canep.2020.101701 IBD BioResource: An Open-Access Platform of 25 000 Patients to Accelerate Research in Crohn's and Colitis Parkes, M., Prescott, N., Mathew, C., Sanderson, J. & Irving, P., Sep 2019, In: Gut. 68, 9, p. 1537-1540 Research output: Contribution to journal › Letter › peer-review. DOIs: https://doi.org/10.1136/gutjnl-2019-318835 Genetic and Inflammatory Biomarkers Classify Small Intestine Inflammation in Asymptomatic First-degree Relatives of Patients With Crohn's Disease Taylor, K. M., Hanscombe, K. B., Prescott, N. J., Iniesta, R., Traylor, M., Taylor, N. S., Fong, S., Powell, N., Irving, P. M., Anderson, S. H., Mathew, C. G., Lewis, C. M. & Sanderson, J. D., 14 Jun 2019, (E-pub ahead of print) In: Clinical Gastroenterology and Hepatology : the official clinical practice journal of the American Gastroenterological Association. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.cgh.2019.05.061 Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population Chen, W. C., Bye, H., Matejcic, M., Amar, A., Govender, D., Khew, Y. W., Beynon, V., Kerr, R., Singh, E., Prescott, N. J., Lewis, C. M., Babb de Villiers, C., Parker, M. I. & Mathew, C. G., Apr 2019, In: Carcinogenesis. 40, 4, p. 513-520 8 p., bgz026. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/carcin/bgz026 The relationship between environmental exposure and genetic architecture of the 2q33 locus with esophageal cancer in South Africa Matejcic, M., Mathew, C. G. & Iqbal Parker, M., 1 Jan 2019, In: Frontiers in Genetics. 10, MAY, 406. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fgene.2019.00406 Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer Traylor, M., Walker, J. L., Corrigan, A. A., Hernandez, M. A., Newhouse, S. J., Folarin, A. A., Patel, H., Ross, P. J., Sanderson, J. D., Spicer, J., Prescott, N. J., Mathew, C. G., Marinaki, A. M. & Lewis, C. M., 1 May 2018, In: PLoS ONE. 13, 5, 11 p., e0188911. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pone.0188911 Exome Sequencing and Genotyping Identify a Rare Variant in NLRP7 Gene Associated With Ulcerative Colitis Onoufriadis, A., Stone, K., Katsiamides, A., Amar, A., Omar, Y., de Lange, K. M., Taylor, K., Barrett, J. C., Pollok, R., Hayee, BH., Mansfield, J. C., Sanderson, J. D., Simpson, M. A., Mathew, C. G. & Prescott, N. J., Mar 2018, In: Journal of Crohn's & colitis. 12, 3, p. 321–326 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1101/182113https://doi.org/10.1093/ecco-jcc/jjx157 Fine-mapping inflammatory bowel disease loci to single-variant resolution International Inflammatory Bowel Disease Genetics Consortium, 13 Jul 2017, In: NATURE. 547, 7662, p. 173-178 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/nature22969 Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism Reynolds, J. J., Bicknell, L. S., Carroll, P., Higgs, M. R., Shaheen, R., Murray, J. E., Papadopoulos, D. K., Leitch, A., Murina, O., Tarnauskaitė, Ž., Wessel, S. R., Zlatanou, A., Vernet, A., von Kriegsheim, A., Mottram, R. M. A., Logan, C. V., Bye, H., Li, Y., Brean, A., Maddirevula, S. & 42 others, Challis, R. C., Skouloudaki, K., Almoisheer, A., Alsaif, H. S., Amar, A., Prescott, N. J., Bober, M. B., Duker, A., Faqeih, E., Seidahmed, M. Z., Al Tala, S., Alswaid, A., Ahmed, S., Al-Aama, J. Y., Altmüller, J., Al Balwi, M., Brady, A. F., Chessa, L., Cox, H., Fischetto, R., Heller, R., Henderson, B. D., Hobson, E., Nürnberg, P., Percin, E. F., Peron, A., Spaccini, L., Quigley, A. J., Thakur, S., Wise, C. A., Yoon, G., Alnemer, M., Tomancak, P., Yigit, G., Taylor, A. M. R., Reijns, M. A. M., Simpson, M. A., Cortez, D., Alkuraya, F. S., Mathew, C. G., Jackson, A. P. & Stewart, G. S., 1 Apr 2017, In: Nature Genetics. 49, 4, p. 537-549 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/ng.3790 Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 Luo, Y., de Lange, K. M., Jostins, L., Moutsianas, L., Randall, J., Kennedy, N. A., Lamb, C. A., McCarthy, S., Ahmad, T., Edwards, C., Serra, E. G., Hart, A., Hawkey, C., Mansfield, J. C., Mowat, C., Newman, W. G., Nichols, S., Pollard, M., Satsangi, J., Simmons, A. & 10 others, Tremelling, M., Uhlig, H., Wilson, D. C., Lee, J. C., Prescott, N. J., Lees, C. W., Mathew, C. G., Parkes, M., Barrett, J. C. & Anderson, C. A., 1 Feb 2017, In: Nature Genetics. 49, 2, p. 186-192 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/ng.3761 View all publications