Dr Cynthia Yu-Wai-Man is an MRC Clinician Scientist at King's College London and Consultant Ophthalmic Surgeon in Glaucoma and Cataract. She qualified from Newcastle University in 2005 and became a fellow of the Royal College of Ophthalmologists (London) in 2013. She completed her subspecialty surgical fellowship in glaucoma at St Thomas' Hospital. During her undergraduate research at the Institute of Genetic Medicine, she identified a novel POLG2 variant in progressive external ophthalmoplegia (Am J Hum Genet 2006). She was an NIHR Crick Clinical Research Fellow at the UCL Institute of Ophthalmology and Moorfields Eye Hospital (PhD 2014-2017). Dr Yu-Wai-Man has also received several prestigious awards like the MRC Clinician Scientist Fellowship in 2020, King's Prize Fellowship in 2019, MRC Confidence-in-Concept Grant in 2016 and EUREKA Translational Medicine Fellowship in 2015.
Dr Yu-Wai-Man leads the state-of-the-art Glaucoma and Gene Therapy Lab at King's College London. She has also set up a unique UK Glaucoma BioResource of RNA, DNA and tissue samples from glaucoma patients, linked to detailed longitudinal phenotyping, which will open unprecedented avenues for translational research and further collaborations. Her lab is focused on multi-omics research in glaucoma, stratified medicine and developing new targeted therapeutics in glaucoma.
Dr Yu-Wai-Man is the Chief Investigator of advanced therapeutics and nanomedicine in glaucoma surgery. Her research goal is to bring new nanomedicine treatments to clinic. Nanotechnology enables the design of multifunctional and targeted therapies, thereby increasing the therapeutic efficacy and reducing the side effects for patients. Dr Yu-Wai-Man has published several peer-reviewed publications, and has shown that targeted siRNA therapeutics and novel therapeutic nanocomplexes increase bleb survival and prevent conjunctival fibrosis after glaucoma surgery.
Fernando, O., Tagalakis, A. D., Awwad, S., Brocchini, S., Khaw, P. T., Hart, S. L. & Yu-Wai-Man, C., 5 Dec 2018, In : Molecular Therapy. 26, 12, p. 2812-2822 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.ymthe.2018.09.004
Tagalakis, A. D., Madaan, S., Larsen, S. D., Neubig, R. R., Khaw, P. T., Rodrigues, I., Goyal, S., Lim, K. S. & Yu-Wai-Man, C., 27 Nov 2018, In : Journal of Nanobiotechnology. 16, 1, 97. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1186/s12951-018-0425-3