Biography
My group's research focuses on engineering metal binding sites into peptides or proteins, through incorporation of a synthetic chelating group or selection of amino acids with affinity for a specific transition metal. I am particularly interested in synthesising and testing new bifunctional chelators that firstly, allow for simple attachment of the chelator to biomolecules such as peptides, proteins, nanoparticles and other targeting vectors, and secondly, allow for coordination of radioactive metal isotopes (including 68Ga, 99mTc, 64Cu, 213Bi, 89Zr, 52Mn and 188Re) that are used in diagnostic imaging or radiotherapy.
These chelator platforms provide versatile tools for nuclear medicine applications, including tracking the migration of cells in vivo, whole body imaging of disease with PET and SPECT, evaluating new protein-based therapies, and targetting radiotherapy of tumours.
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Zhao, T., Ma, M., Ourselin, S., Vercauteren, T. & Xia, W., Mar 2022, In: Photoacoustics. 25, 9 p., 100323. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.pacs.2021.100323
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Hungnes, I., Al Salemee, F., Gawne, P., Eykyn, T. R., Atkinson, A., Terry, S., Clarke, F., Blower, P. J., Pringle, P. G. & Ma, M., 28 Nov 2021, In: Dalton Transactions. 50, 44, p. 16156-16165 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1039/D1DT03177E
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Zhao, T., Ma, M., Ourselin, S., Vercauteren, T. & Xia, W., 16 Nov 2021, 2021 IEEE International Ultrasonics Symposium (IUS). IEEE, p. 1-4 4 p. Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review. DOIs: https://doi.org/10.1109/IUS52206.2021.9593659
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Spyrou, B., Hungnes, I. N., Mota, F., Bordoloi, J., Blower, P. J., White, J. M., Ma, M. T. & Donnelly, P. S., 6 Sep 2021, In: INORGANIC CHEMISTRY. 60, 17, p. 13669-13680 12 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1021/acs.inorgchem.1c01992
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Young, J., Jauregui-Osoro, M., Wong, W. L., Cooper, M., Cook, G., Barrington, S., Ma, M., Blower, P. & Aboagye, E. O., 21 Jul 2021, (E-pub ahead of print) In: Nuclear Medicine Communications. Research output: Contribution to journal › Article › peer-review
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Farleigh, M., Pham, T., Yu, Z., Kim, J., Sunassee, K., Firth, G., Forte, N., Chudasama, V., Baker, J. R., Long, N. J., Rivas, C. & Ma, M., 21 Jul 2021, In: Bioconjugate Chemistry. 32, 7, p. 1214-1222 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1021/acs.bioconjchem.0c00710
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Ma, M. T. & Lewis, J. S., 21 Jul 2021, In: Bioconjugate Chemistry. 32, 7, p. 1175-1176 2 p. Research output: Contribution to journal › Editorial › peer-review. DOIs: https://doi.org/10.1021/acs.bioconjchem.1c00303
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Young, J., Ma, M., Eykyn, T., Atkinson, A., Abbate, V., Cilibrizzi, A., Hider, R. & Blower, P., 15 Jun 2021, In: Bioorganic & medicinal chemistry letters. 42, 128044. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.bmcl.2021.128044
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Verger, E., Cheng, J., De Santis, V., Luck, M., Jackson, J., Imberti, C., Fruhwirth, G., Blower, P., Ma, M., Burnham, D. & Terry, S., 10 Jun 2021, (Accepted/In press) In: Nuclear Medicine and Biology. Research output: Contribution to journal › Article › peer-review
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Blower, J., Ma, M., Al-Salemee, F. & Gee, T., 18 May 2021, In: Chemical communications (Cambridge, England). 57, 40, p. 4962-4965 4 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1039/d1cc00495f