Biography
My group's research focuses on engineering metal binding sites into peptides or proteins, through incorporation of a synthetic chelating group or selection of amino acids with affinity for a specific transition metal. I am particularly interested in synthesising and testing new bifunctional chelators that firstly, allow for simple attachment of the chelator to biomolecules such as peptides, proteins, nanoparticles and other targeting vectors, and secondly, allow for coordination of radioactive metal isotopes (including 68Ga, 99mTc, 64Cu, 213Bi, 89Zr, 52Mn and 188Re) that are used in diagnostic imaging or radiotherapy.
These chelator platforms provide versatile tools for nuclear medicine applications, including tracking the migration of cells in vivo, whole body imaging of disease with PET and SPECT, evaluating new protein-based therapies, and targetting radiotherapy of tumours.
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Prueller, J., Hofer, I., Ganassi, M., Heher, P., Ma, M. & Zammit, P., 4 Aug 2020, (Accepted/In press) In : Cancer Gene Therapy. Research output: Contribution to journal - Article
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Jackson, J. A., Hungnes, I. N., Ma, M. T. & Rivas, C., 18 Mar 2020, In : Bioconjugate Chemistry. 31, 3, p. 483-491 9 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1021/acs.bioconjchem.0c00015
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Mota, F., Ordonez, A. A., Firth, G., Ruiz-Bedoya, C. A., Ma, M. T. & Jain, S. K., 12 Mar 2020, In : Journal of Medicinal Chemistry. 63, 5, p. 1964-1977 14 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1021/acs.jmedchem.9b01623
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Cusnir, R., Cakebread, A., Cooper, M. S., Young, J. D., Blower, P. J. & Ma, M. T., Nov 2019, In : RSC Advances. 9, 64, p. 37214-37221 8 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1039/C9RA07723E
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Imberti, C., Chen, Y-L., Foley, C. A., Ma, M. T., Paterson, B. M., Wang, Y., Young, J. D., Hider, R. C. & Blower, P. J., May 2019, In : Dalton Transactions. 48, 13, p. 4299-4313 15 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1039/c8dt04454f
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Mann, P. B., Mcgregor, I. J., Bourke, S., Burkitt-gray, M., Fairclough, S., Ma, M. T., Hogarth, G., Thanou, M., Long, N. & Green, M., 1 Feb 2019, In : Nanoscale Advances. 1, 2, p. 522-526 5 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1039/C8NA00325D
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Morais, M. & Ma, M., 24 Oct 2018, In : Drug Discovery Today: Technologies. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.ddtec.2018.10.002
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Smith, A. J., Gawne, P. J., Ma, M. T., Blower, P. J., Southworth, R. & Long, N. J., 17 Oct 2018, In : Dalton transactions (Cambridge, England : 2003). Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1039/c8dt02966k
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Lobeek, D., Franssen, G. M., Ma, M. T., Wester, H. J., Decristoforo, C., Oyen, W. J. G., Boerman, O. C., Terry, S. Y. A. & Rijpkema, M., 1 Aug 2018, In : Journal of Nuclear Medicine. 59, 8, p. 1296-1301 6 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.2967/jnumed.117.206979
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Tsionou, M. I., Knapp, C. E., Foley, C. A., Munteanu, C. R., Cakebread, A., Imberti, C., Eykyn, T. R., Young, J. D., Paterson, B. M., Blower, P. J. & Ma, M. T., 25 Oct 2017, In : RSC Advances. 7, 78, p. 49586-49599 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1039/C7RA09076E