Biography
My group's research focuses on engineering metal binding sites into peptides or proteins, through incorporation of a synthetic chelating group or selection of amino acids with affinity for a specific transition metal. I am particularly interested in synthesising and testing new bifunctional chelators that firstly, allow for simple attachment of the chelator to biomolecules such as peptides, proteins, nanoparticles and other targeting vectors, and secondly, allow for coordination of radioactive metal isotopes (including 68Ga, 99mTc, 64Cu, 213Bi, 89Zr, 52Mn and 188Re) that are used in diagnostic imaging or radiotherapy.
These chelator platforms provide versatile tools for nuclear medicine applications, including tracking the migration of cells in vivo, whole body imaging of disease with PET and SPECT, evaluating new protein-based therapies, and targetting radiotherapy of tumours.
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Floresta, G., Memdouh, S., Pham, T., Ma, M. T., Blower, P. J., Hider, R. C., Abbate, V. & Cilibrizzi, A., 11 Aug 2022, In: Dalton Transactions. 51, 34, p. 12796-12803 8 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1039/d2dt00980c
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Zhao, T., Pham, T., Baker, C., Ma, M., Ourselin, S., Vercauteren, T., Zhang, E. Z., Beard, P. C. & Xia, W., 27 Jul 2022, In: Biomedical Optics Express. 13, 8, p. 4414-4428 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1364/BOE.463057
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Rigby, A., Firth, G., Rivas, C., Pham, T., Kim, J., Phanopoulos, A., Wharton, L., Ingham, A., Li, L., Ma, M. T., Orvig, C., Blower, P. J., Terry, S. Y. A. & Abbate, V., 20 Jul 2022, In: Bioconjugate chemistry. 33, 7, p. 1422-1436 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1021/acs.bioconjchem.2c00284
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Rigby, A., Firth, G., Rivas, C., Pham, T., Kim, J., Phanopoulos, A., Wharton, L., Ingham, A., Li, L., Ma, M., Orvig, C., Blower, P., Terry, S. & Abbate, V., 23 Jun 2022, (Accepted/In press) In: Bioconjugate Chemistry. Research output: Contribution to journal › Article › peer-review
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Koller, A. J., Saini, S., Chaple, I. F., Joaqui-Joaqui, M. A., Paterson, B. M., Ma, M. T., Blower, P. J., Pierre, V. C., Robinson, J. R., Lapi, S. E. & Boros, E., 23 May 2022, In: Angewandte Chemie - International Edition. 61, 22, e202201211. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/anie.202201211
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Frei, A., Rigby, A., Yue, T. T. C., Firth, G., Ma, M. T. & Long, N. J., 23 May 2022, In: Dalton Transactions. 51, 23, p. 9039-9048 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1039/d2dt01074g
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Zhao, T., Ma, M., Ourselin, S., Vercauteren, T. & Xia, W., Mar 2022, In: Photoacoustics. 25, 9 p., 100323. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.pacs.2021.100323
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Prueller, J., Pham, T., Blower, J., Charoenphun, P., Volpe, A., Sunassee, K., Mullen, G., Blower, P., Smith, R. & Ma, M., 2022, In: RSC Chemical Biology. Research output: Contribution to journal › Article › peer-review
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Cooper, S. M., White, A. J. P., Eykyn, T. R., Ma, M. T., Miller, P. W. & Long, N. J., 2022, (Accepted/In press) In: INORGANIC CHEMISTRY. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1021/acs.inorgchem.2c00693
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Hungnes, I., Al Salemee, F., Gawne, P., Eykyn, T. R., Atkinson, A., Terry, S., Clarke, F., Blower, P. J., Pringle, P. G. & Ma, M., 28 Nov 2021, In: Dalton Transactions. 50, 44, p. 16156-16165 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1039/D1DT03177E