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Espe  Perucha

Dr Espe Perucha

Senior Lecturer in Experimental Rheumatology

Research interests

  • Immunology

Biography

I did my PhD in Medicine in Spain. In 2006 I was recruited to KCL to work as a post-doc in the translational portfolio of Dr Maria Hernandez-Fuentes, Prof. Robert Lechler and Prof. Graham Lord laboratories. In 2012 I moved to Prof. Andre Cope’s team, where my research focused on dissecting the pathways for aberrant T cell activation in Rheumatoid Arthritis patients as part of the EU-funded BTCure project. Here, we undercovered a new role for cellular metabolism to regulate immune cell function, which ended up being the main research theme of my lab. The SpLAB started in late 2017, when I got a lecturer position at KCL. We are based at the Centre for Inflammation Biology and Cancer Immunology (CIBCI). The lab is interested on mechanisms of immune activation and tolerance in man, from molecules to cells and the whole individual. We work on understanding how the immune system activates and also regulates, with focus on the interaction between cellular metabolism and immune function. Our final aim is to find new ways to modulate the human immune response, in order to restore homeostasis (which is defective in chronic inflammation) or boost the effector arm, which may benefit the body when it fights infection or cancer.

    Research

    Perucha Group

    Perucha Group is interested on mechanisms of immune activation and tolerance in man, from molecules to cells and the whole individual.

    The NutrImmune Study

    Investigating how diet can optimise our immune response to flu vaccines. We're recruiting healthy adults, aged 40-64 years old, who consume 2+ snacks per day.

    Project status: Ongoing

    Lipids and Membranes Research Interest Group

    A Lipids and Membranes Research Interest Group

    Immunometabolism (iMet) Research Interest Group (RIG)

    The aim of the i-met research interest group is to stimulate novel collaborations in the field of Immunometabolism, a young but rapidly growing field of research.

      Research

      Perucha Group

      Perucha Group is interested on mechanisms of immune activation and tolerance in man, from molecules to cells and the whole individual.

      The NutrImmune Study

      Investigating how diet can optimise our immune response to flu vaccines. We're recruiting healthy adults, aged 40-64 years old, who consume 2+ snacks per day.

      Project status: Ongoing

      Lipids and Membranes Research Interest Group

      A Lipids and Membranes Research Interest Group

      Immunometabolism (iMet) Research Interest Group (RIG)

      The aim of the i-met research interest group is to stimulate novel collaborations in the field of Immunometabolism, a young but rapidly growing field of research.