Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α-TAB1 Complexes Nichols, C., Ng, J., Keshu, A., Kelly, G., Conte, M. R., Marber, M. S., Fraternali, F. & De Nicola, G. F., 23 Jul 2020, In : Journal of Medicinal Chemistry. 63, 14, p. 7559-7568 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1021/acs.jmedchem.0c00403 The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules De Nicola, G. F., Bassi, R., Nichols, C., Fernandez-Caggiano, M., Golforoush, P. A., Thapa, D., Anderson, R., Martin, E. D., Verma, S., Kleinjung, J., Laing, A., Hutchinson, J. P., Eaton, P., Clark, J. & Marber, M. S., 23 Aug 2018, In : JCI Insight. 3, 16 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1172/jci.insight.121144 TAB1-induced autoactivation of p38α mitogen-activated protein kinase is crucially dependent on threonine 185 Thapa, D., Nichols, C., Bassi, R., Martin, E. D., Verma, S., Conte, M. R., De Santis, V., De Nicola, G. F. & Marber, M. S., 1 Mar 2018, In : Molecular and Cellular Biology. 38, 5, e00449-17. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1128/MCB.00409-17 Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1 De Nicola, G. F., Martin, E. D., Chaikuad, A., Bassi, R., Clark, J., Martino, L., Verma, S., Sicard, P., Tata, R., Atkinson, R. A., Knapp, S., Conte, M. R. & Marber, M. S., Oct 2013, In : NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 20, 10, p. 1182-1190 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/nsmb.2668 New Therapeutic Targets in Cardiology p38 Alpha Mitogen-Activated Protein Kinase for Ischemic Heart Disease Martin, E. D., De Nicola, G. F. & Marber, M. S., 17 Jul 2012, In : Circulation (Baltimore). 126, 3, p. 357-368 12 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1161/CIRCULATIONAHA.111.071886 Binding Properties of the Calcium-Activated F2 Isoform of Lethocerus Troponin C Martin, S. R., Avella, G., Adrover, M., de Nicola, G. F., Bullard, B. & Pastore, A., 22 Mar 2010, In : Biochemistry. 50, 11, p. 1839 - 1847 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1021/bi102076s View all publications