Dr Greg Knock

I am interested in the signalling pathways involved in the modulation of smooth muscle contractility, with a focus on the RhoA/Rho-kinase pathway and non-receptor tyrosine kinases and their regulation by G protein-coupled receptors, reactive oxygen species and inflammatory mediators.  I am currently investigating these signalling pathways and how they interact, in both airway smooth muscle and pulmonary artery smooth muscle with an aim, therefore, to establishing the relevance of that interaction to both airway hyper-responsiveness in asthma and pulmonary hypertension.