Overview publication:

Davies, M. R., Kalsi, G., Armour, C., Jones, I., McIntosh, A., Smith, D. J., Beange, I., Brailean, A., Cleare, A. J., Coleman, J. R. I., Curtis, C. J., Curzons, S. C. B., Davis, K. A. S., Downey, L., Gault, V., Goldsmith, K. A., Hammond Bennett, M., Hirose, Y., Hotopf, M. H., Huebel, C. Leng, J., Mason, B. D., McAtarsney-Kovacs, M., Monssen, D., Palaiologou, E., Pariante, C. M., Parikh, S., Peel, A. J., Price, R., Rimes, K. A., Rogers, H. C., Skelton, M., Spaul, A., Almira Suarez, E. L., Sykes, B. L., Thomas, K., White, K. M., Young, A.,Vassos, E., Veale, D., Wingrove, J., Eley, T. C. & Breen, G. D. (2019) The Genetic Links to Anxiety and Depression (GLAD) Study: online recruitment into the largest recontactable study of depression and anxiety, Behaviour Research and Therapy. 123, 103503

Some examples of our work on the genetics of anxiety, depression, treatment seeking and treatment outcomes are provided below:

Di Gessa, G., Maddock, J., Green, M., Thompson, E., McElroy, E., Davies, H., Mundy, J., Stevenson, A., Kwong, A., Griffith, G., Katikireddi, S., Niedzwiedz, C., Ploubidis, G., Fitzsimons, E., Henderson, M., Silverwood, R., Chaturvedi, N., Breen, G., Steves, C., Steptoe, A., Porteous, D., Patalay, P. (2022). Pre-pandemic mental health and disruptions to healthcare, economic and housing outcomes during the COVID-19 pandemic: Evidence from 12 UK longitudinal studies. The British Journal of Psychiatry, 220, 21-30. doi:10.1192/bjp.2021.132.
Davies, M. R., Buckman, J. E., Adey, B. N., Armour, C., Bradley, J. R., Curzons, S. C., Davis, K. A. S., Goldsmith, K. A., Hirsch, C. R., Hotopf, M., Hübel, C., Jones, I. R., Kalsi, G., Krebs, G., Lin, Y., Marsh, I., McAtarsney-Kovacs, M., McIntosh, A. M., Monssen, D., Peel, A. J., Rogers, H. C., Skelton, M., Smith, D. J., Ter-Kuile, A., Thompson, K. N., Veale, D., Walters, J. T. R., Zahn, R., Breen, G., & Eley, T. C. (2021). Comparison of algorithm-based versus single-item diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts. medRxiv. https://doi.org/10.1101/2021.01.08.21249434
Thompson, K. N., Hübel, C., Cheesman, R., Adey, B. N., Armour, C., Davies, M. R., Hotopf, M., Jones, I., Kalsi, G., McIntosh, A. M., Monssen, D., Peel, A. J., Rogers, H. C., Skelton, M., Smith, D. J., Walters, J. T. R., Breen, G. & Eley, T. C. (2021). Age and sex-related variability in the presentation of generalised anxiety and depression. Depression Anxiety, 38, 1054-1065. https://doi.org/10.1002/da.23213
Peel, A. J., Armour C., Buckman J. E. J., Coleman J. R. I., Curzons S. C. B., Davies M. R., Hübel C., Jones I., Kalsi G., McAtarsney-Kovacs M., McIntosh A. M., Monssen D., Mundy J., Rayner C., Rogers H. C., Skelton M., ter Kuile A., Thompson K. N., Breen G., Danese A.* & Eley* T. C. (2021). Comparison of depression and anxiety symptom networks in reporters and non-reporters of lifetime trauma in two samples of differing severity. Journal of Affective Disorders Reports, 6, 100201. https://doi.org/10.1016/j.jadr.2021.100201
Coleman, J.R.I., Peyrot, W.J., Purves, K.L., ...Hotopf, M., Eley, T. C*., Breen*, G. (2020). Genome- wide gene- environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25, 1430- 1446. https://doi.org/10.1038/s41380-019-0546-6
Purves, K. L., Coleman, J. R. I., Meier, S.M., Rayner, C., Cheesman, R., ... Breen*, G., Eley, T. C*. (2020). A major role for common genetic variation in anxiety disorders. Molecular Psychiatry, 25, 3292–3303. https://doi.org/10.1038/s41380-019-0559-1
Rayner, C., Coleman, J.R.I., Purves, K.L., Cheesman, R., Huebel, C., Gaspar, H.A., Glanville, K.P., Krebs, G.C., Morneau-Vaillancourt, G., Breen, G., Eley, T. C. (2019). Genetic influences on treatment- seeking for common mental health problems in the UK biobank. Behaviour Research and Therapy, 121, 103413. https://doi.org/10.1016/j.brat.2019.103413
Keers, R., Coleman, J., Lester, K., Roberts, S., Breen, G., ... Eley, T. C. (2016). A genome-wide test of the differential susceptibility hypothesis reveals a genetic predictor of differential response to psychological treatments for child anxiety disorders. Psychotherapy and Psychosomatics, 85, 146-158.

Professor Ian Jones

Research

Research

GLAD: Genetic Links to Anxiety and Depression

Research

GLAD: Genetic Links to Anxiety and Depression