
Professor James Clark
Professor of Cardiovascular and Physiology Education
- Head of the Physiology Teaching Department
- Education Lead for School of Cardiovascular and Metabolic Medicine & Sciences
Research interests
- Cardiovascular
Biography
Professor James Clark has a degree in Applied Biology from the University of Bath and a PhD in Surgery from University College London. Working on the processes involved in ischaemic and pharmacological preconditioning during his PhD and subsequent post-doctoral research he was part of the team to develop novel carbon monoxide releasing molecules (CORMs) which can be used to elucidate the functional role of carbon monoxide in biological systems and led to the formation of the start-up company (HemoCORM).
In 2003 he was appointed a Research Associate in the Cardiovascular Division at King’s where he joined the group of Prof. Mike Marber and continued research on cardiac-protection and pharmacological preconditioning. In 2007, Professor Clark was awarded a British Heart Foundation (BHF) Intermediate Research Fellowship to carry out work on carbon monoxide-mediated cardio-protection. In February 2010, he was appointed to a Lectureship in Aerospace Physiology within the academic department of Physiology to teach on undergraduate and masters’ level courses. Professor Clark was promoted to the post of Reader in Human & Applied Physiology in 2019 and to the position of Professor of Cardiovascular and Physiology Education in 2022.
Professor Clark work now focuses on scientific and medical education and his teaching experience spans whole body integrative and applied physiology including, hyperbaric and diving medicine, the mechanisms that control cardiac function in health and disease and essential academic skills including data analysis and presentation.
50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper-buoyancy floatation versus 15 min sitting upright
Marcos-Lorenzo, D., Lysandrou, C., Sudres, L., Gil-Martinez, A., Swanenburg, J., Clark, J. E. & Green, D. A., 2024, (Accepted/In press) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
An overview of case studies of innovative hybrid flexible pedagogical approaches
Clark, J. E., Detyna, M. & Sami Siddiqui, M., 1 Aug 2024, In: International Journal of Innovation in Education.Research output: Contribution to journal › Article › peer-review
Correction to: Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction (Cells, (2022), 11, 24, (4050), 10.3390/cells11244050)
Ruchaya, P. J., Lewis-McDougall, F. C., Sornkarn, N., Amin, S., Grimsdell, B., Shaalan, A., Gritti, G., Soe, K. T., Clark, J. E. & Ellison-Hughes, G. M., Jun 2024, In: Cells. 13, 11, 895.Research output: Contribution to journal › Comment/debate › peer-review
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation
Knight, H., Abis, G., Kaur, M., Green, H. L. H., Krasemann, S., Hartmann, K., Lynham, S., Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R. T., Eaton, P. & Rudyk, O., 8 Dec 2023, In: Circulation Research. 133, 12, p. 966-988 23 p.Research output: Contribution to journal › Article › peer-review
Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy
Thakore, P., Clark, J. E., Aubdool, A. A., Thapa, D., Starr, A., Fraser, P. A., Farrell-Dillon, K., Fernandes, E. S., McFadzean, I. & Brain, S. D., 4 Apr 2024, In: Biomolecules. 14, 4, 442.Research output: Contribution to journal › Article › peer-review
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation
Knight, H., Abis, G., Kaur, M., Green, H., Krasemann, S., Hartmann, K., Lynham, S., Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R., Eaton, P. & Rudyk, O., 2 Nov 2023, (Accepted/In press) In: Circulation Research. 133Research output: Contribution to journal › Article › peer-review
Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction
Ruchaya, P. J., Lewis-McDougall, F. C., Sornkarn, N., Amin, S., Grimsdell, B., Shaalan, A., Gritti, G., Soe, K. T., Clark, J. E. & Ellison-Hughes, G. M., 14 Dec 2022, In: Cells. 11, 24, 21 p., 4050.Research output: Contribution to journal › Article › peer-review
The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart
Mele, L., Maskell, L. J., Stuckey, D. J., Clark, J. E., Heads, R. J. & Budhram-mahadeo, V. S., 14 Aug 2019, In: Cell death & disease. 10, 8, p. 621-638 18 p., 621.Research output: Contribution to journal › Article › peer-review
Aged-senescent cells contribute to impaired heart regeneration
Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Teoh, T. S., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 2019, In: AGING CELL. 18, 3, e12931.Research output: Contribution to journal › Article › peer-review
Dynamic heart rate response to multi-day unsupported ultra-endurance cycle racing: a case report
Brayson, D., Frigiola, A. & Clark, J. E., 12 Dec 2018, (Accepted/In press) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
The role of single-incision laparoscopic surgery in abdominal and pelvic surgery: a systematic review
Ahmed, K., Wang, T. T., Patel, V. M., Nagpal, K., Clark, J., Ali, M., Deeba, S., Ashrafian, H., Darzi, A., Athanasiou, T. & Paraskeva, P., Feb 2011, In: Surgical endoscopy. 25, 2, p. 378-96 19 p.Research output: Contribution to journal › Review article › peer-review
Detection of anthracycline-induced cardiotoxicity using perfusion-corrected 99mTc sestamibi SPECT
Safee, Z. M., Baark, F., Waters, E. C. T., Veronese, M., Pell, V. R., Clark, J. E., Mota, F., Livieratos, L., Eykyn, T. R., Blower, P. J. & Southworth, R., 2019, In: Scientific Reports. 9, p. 216-227 11 p., 216.Research output: Contribution to journal › Article › peer-review
Tissue acidosis does not mediate the hypoxia selectivity of [64Cu][Cu(ATSM)] in the isolated perfused rat heart
Baark, F., Shaughnessy, F., Pell, V. R., Clark, J. E., Eykyn, T. R., Blower, P. & Southworth, R., 24 Jan 2019, In: Scientific Reports. 9, 10 p., 499.Research output: Contribution to journal › Article › peer-review
The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
De Nicola, G. F., Bassi, R., Nichols, C., Fernandez-Caggiano, M., Golforoush, P. A., Thapa, D., Anderson, R., Martin, E. D., Verma, S., Kleinjung, J., Laing, A., Hutchinson, J. P., Eaton, P., Clark, J. & Marber, M. S., 23 Aug 2018, In: JCI Insight. 3, 16, p. 1-17Research output: Contribution to journal › Article › peer-review
Author Correction: Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
Sharif-Paghaleh, E., Yap, M. L., Puhl, S. L., Badar, A., Torres, J. B., Chuamsaamarkkee, K., Kampmeier, F., Smith, R. A., Clark, J., Blower, P. J., Sacks, S. & Mullen, G. E., 13 Mar 2018, In: Scientific Reports. 8, 1, p. 4687 1 p.Research output: Contribution to journal › Article › peer-review
Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice
Garrett, N., Pombo, J., Umpierrez, M., Clark, J. E., Simmons, M. & Girardi, G., 19 Apr 2018, (E-pub ahead of print) In: JCI Insight. 3, 8Research output: Contribution to journal › Article › peer-review
p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin
Loonat, A. A., Martin, E. D., Sarafraz-Shekary, N., Tilgner, K., Hertz, N. T., Levin, R., Shokat, K. M., Burlingame, A. L., Arabacilar, P., Uddin, S., Thomas, M., Marber, M. S. & Clark, J. E., 31 Dec 2019, In: Faseb Journal. 33, 12, p. 13131-13144 14 p.Research output: Contribution to journal › Article › peer-review
PET Imaging of Cardiac Hypoxia: Hitting Hypoxia Where It Hurts
Pell, V. R., Baark, F., Mota, F., Clark, J. E. & Southworth, R., 2018, In: Current Cardiovascular Imaging Reports. 11, 3, p. 7Research output: Contribution to journal › Review article › peer-review
Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
Sharif-Paghaleh, E., Clark, J., Yap, M. L., Badar, A., Baguna Torres, J., Puhl, S. L., Blower, P. J., Chuamsaamarkkee, K., Kampmeier, F., Smith, R., Sacks, S. H. & Mullen, G. E. D., 23 Nov 2017, In: Scientific Reports. 7, 1, 16090.Research output: Contribution to journal › Article › peer-review
Cardioprotection by an anti-MASP-2 antibody in a murine model of myocardial infarction
Clark, J. E., Dudler, T., Marber, M. S. & Schwaeble, W., 2018, In: Open Heart. 5, e000652.Research output: Contribution to journal › Article › peer-review
Loss of protein kinase novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation and exacerbated ischaemia-reperfusion injury
Francois, A. A., Obasanjo-Blackshire, K., Clark, J. E., Boguslavskyi, A., Holt, M. R., Parker, P. J., Marber, M. S. & Heads, R. J., 16 Oct 2017, (E-pub ahead of print) In: Cardiovascular Research.Research output: Contribution to journal › Article › peer-review
A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy and Heart Failure
Aubdool, A. A., Thakore, P., Argunhan, F., Smillie, S.-J., Schnelle, M., Srivastava, S., Alawi, K. M., Wilde, E., Mitchell, J., Farrell-Dillon, K., Richards, D. A., Maltese, G., Siow, R. C., Nandi, M., Clark, J. E., Shah, A. M., Sams, A. & Brain, S. D., 25 Jul 2017, In: Circulation (Baltimore). 136, 4, p. 367-383Research output: Contribution to journal › Article › peer-review
Effect of postnatal Leptin on cardiac structure and function
Apel, A.-M. S., Shattock, M. J., Poston, L., Pombo, J., Clark, J., Rudyk, O. V. & Coen, C., 2013, In: Acta Obstetricia et Gynecologica Scandinavica.Research output: Contribution to journal › Meeting abstract › peer-review
ELUCIDATING THE ROLE OF P38γ IN PATHOLOGICAL CARDIAC HYPERTROPHY
Loonat, A. A., Hunt, F., Choi, S. H., Marber, M. S., Martin, E. D., T Hertz, N., Levin, B., M Shokat, K., L Burlingame, A., Marber, M. S. & Clark, J., Dec 2014, In: Heart. 100Research output: Contribution to journal › Meeting abstract › peer-review
P38γ mitogen-Activated Protein Kinase is a Mediator of Pathological Cardiac Hypertophy
Clark, J., Sept 2014, In: Heart. 100, 1.Research output: Contribution to journal › Meeting abstract › peer-review
DELETERIOUS EFFECTS OF COLD AIR INHALATION DURING EXERCISE IN CORONARY ARTERY DISEASE PATIENTS: DIFFERENTIAL EFFECTS OF ISOMETRIC AND DYNAMIC EXERCISE
Clark, J., Harwood, A., Fok, H. & Williams, R., Jun 2015, In: Journal of Hypertension. 33Research output: Contribution to journal › Article › peer-review
Response to role of hyperleptinemia in the regulation of blood pressure and cardiac function
Samuelsson, A. M., Clark, J., Rudyk, O., Shattock, M. J., Bae, S. E., South, T., Pombo, J., Redington, K., Uppal, E., Coen, C. W., Poston, L. & Taylor, P. D., Jan 2014, In: Hypertension. 63, 1, 1 p., e2.Research output: Contribution to journal › Letter › peer-review
Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury
Baker, J. O., Tyther, R., Liebetrau, C., Clark, J., Howarth, R., Patterson, T., Möllmann, H., Nef, H., Sicard, P., Kailey, B., Devaraj, R., Redwood, S. R., Kunst, G., Weber, E. & Marber, M. S., May 2015, In: Basic Research in Cardiology. 110, 3, 14 p., 478.Research output: Contribution to journal › Article › peer-review
Moving in extreme environments: inert gas narcosis and underwater activities
Clark, J. E., 24 Feb 2015, In: Extreme physiology & medicine. 4, 7 p., 1.Research output: Contribution to journal › Article › peer-review
Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension
Bodkin, J. V., Thakore, P., Aubdool, A. A., Liang, L., Fernandes, E. S., Nandi, M., Spina, D., Clark, J. E., Aaronson, P. I., Shattock, M. J. & Brain, S. D., Aug 2014, In: Pharmacology research & perspectives. 2, 4, 17 p., e00052.Research output: Contribution to journal › Article › peer-review
Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman
Boguslavskyi, A., Pavlovic, D., Aughton, K., Clark, J. E., Howie, J., Fuller, W. & Shattock, M. J., 1 Oct 2014, In: Cardiovascular Research. 104, p. 72-78 6 p.Research output: Contribution to journal › Article › peer-review
Transient therapeutic inhibition of MASP-2 dependent lectin pathway functional activity provides a significant degree of protection from ischaemia/reperfusion injury in models of myocardial infarction and stroke
Chrysanthou, E., Clark, J., Lynch, N., Dudler, T., Marber, M., Samani, N. J. & Schwaeble, W. J., 2013, 14th European meeting on Complement in Human Disease.Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
De Nicola, G. F., Martin, E. D., Chaikuad, A., Bassi, R., Clark, J., Martino, L., Verma, S., Sicard, P., Tata, R., Atkinson, R. A., Knapp, S., Conte, M. R. & Marber, M. S., Oct 2013, In: NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 20, 10, p. 1182-1190 9 p.Research output: Contribution to journal › Article › peer-review
Trapped Platelets Activated in Ischemia Initiate Ventricular Fibrillation
Dhanjal, T., Medina, R., Leem, J., Clark, J., Southworth, R. & Curtis, M., Oct 2013, In: Circulation-Arrhythmia And Electrophysiology. 6, 5, p. 995-1001 7 p., N/A.Research output: Contribution to journal › Article › peer-review
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing
Evans, M. A., Smart, N., Dubé, K. N., Bollini, S., Clark, J. E., Evans, H. G., Taams, L. S., Richardson, R., Lévesque, M., Martin, P., Mills, K., Riegler, J., Price, A., Lythgoe, M. F. & Riley, P. R., 2 Jul 2013, In: Nature Communications. 4, 2081.Research output: Contribution to journal › Article › peer-review
Experimental hyperleptinemia in neonatal rats leads to selective leptin responsiveness, hypertension, and altered myocardial function
Samuelsson, A. M., Clark, J., Rudyk, O., Shattock, M. J., Bae, S. E., South, T., Pombo, J., Redington, K., Uppal, E., Coen, C. W., Poston, L. & Taylor, P. D., Sept 2013, In: Hypertension. 62, 3, p. 627-633 7 p.Research output: Contribution to journal › Article › peer-review
Patent foramen ovale and scuba diving: a practical guide for physicians on when to refer for screening
Sykes, O. & Clark, J. E., 2013, In: Extreme physiology & medicine. 2, 1, 10.Research output: Contribution to journal › Article › peer-review
Postnatal Leptin Administration in Naive Rat Pups Leads to Leptin Resistance, Hypertension and Gender Specific Myocardial Dysfunction
Samuelsson, A.-M., Clark, J., Shattock, M. J. J., Pombo, J., Coen, C., Poston, L. & Taylor, P. D., Sept 2011, In: Journal of Developmental Origins of Health and Disease. 2, p. S12-S12 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
Advancements in pressure–volume catheter technology – stress remodelling after infarction
Clark, J. & Marber, M., Mar 2013, In: Experimental Physiology. 98, 3, p. 614-621 8 p.Research output: Contribution to journal › Article › peer-review
Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3
Risebro, C. A., Petchey, L. K., Smart, N., Gomes, J., Clark, J., Vieira, J. M., Yanni, J., Dobrzynski, H., Davidson, S., Zuberi, Z., Tinker, A., Shui, B., Tallini, Y. I., Kotlikoff, M. I., Miquerol, L., Schwartz, R. J. & Riley, P. R., 6 Jul 2012, In: Circulation Research. 111, 2, p. e19-e31 13 p.Research output: Contribution to journal › Article › peer-review
The role of RIP2 in p38 MAPK activation in the stressed heart
Jacquet, S., Nisbino, Y., Kumphune, S., Sicard, P., Clark, J., Kobayashi, K. S., Flavell, R. A., Eickhoff, J., Cotten, M. & Marber, M. S., 2 Apr 2008, In: Journal of Molecular and Cellular Cardiology. 44, 4, p. 714-714 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
Schwaeble, W. J., Lynch, N. J., Clark, J. E., Marber, M., Samani, N. J., Ali, Y. M., Dudler, T., Parent, B., Lhotta, K., Wallis, R., Farrar, C. A., Sacks, S., Lee, H., Zhang, M., Iwaki, D., Takahashi, M., Fujita, T., Tedford, C. E. & Stover, C. M., 3 May 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7523 - 7528 6 p.Research output: Contribution to journal › Article › peer-review
Myocardial stress remodelling after regional infarction is independent of glycogen synthase kinase-3 inactivation
Webb, I. G., Sicard, P., Clark, J. E., Redwood, S. & Marber, M. S., Nov 2010, In: Journal of Molecular and Cellular Cardiology. 49, 5, p. 897 - 900 4 p.Research output: Contribution to journal › Article › peer-review
Constitutive glycogen synthase kinase-3α/β activity protects against chronic β-adrenergic remodelling of the heart
Webb, I. G., Nishino, Y., Clark, J. E., Murdoch, C., Walker, S. J., Makowski, M. R., Botnar, R. M., Redwood, S. R., Shah, A. M. & Marber, M. S., Aug 2010, In: Cardiovascular Research. 87, 3, p. 494 - 503 10 p.Research output: Contribution to journal › Article › peer-review
The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning
Sicard, P., Clark, J. E., Jacquet, S., Mohammadi, S., Arthur, J. S. C., O'Keefe, S. J. & Marber, M. S., Jun 2010, In: Journal of Molecular and Cellular Cardiology. 48, 6, p. 1324 - 1328 5 p.Research output: Contribution to journal › Article › peer-review
A Chemical Genetic Approach Reveals That p38 alpha MAPK Activation by Diphosphorylation Aggravates Myocardial Infarction and Is Prevented by the Direct Binding of SB203580
Kumphune, S., Bassi, R., Jacquet, S., Sicard, P., Clark, J. E., Verma, S., Avkiran, M., O'Keefe, S. J. & Marber, M. S., 2010, In: Journal of Biological Chemistry. 285, 5, p. 2968-2975 8 p.Research output: Contribution to journal › Article › peer-review
Identification of Cardiac Myosin-binding Protein C as a Candidate Biomarker of Myocardial Infarction by Proteomics Analysis
Jacquet, S., Yin, X., Sicard, P., Clark, J., Kanaganayagam, G. S., Mayr, M. & Marber, M. S., Dec 2009, In: MOLECULAR AND CELLULAR PROTEOMICS. 8, 12, p. 2687 - 2699 13 p.Research output: Contribution to journal › Article › peer-review
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia
Gorog, D. A., Jabr, R. I., Tanno, M., Sarafraz, N., Clark, J. E., Fisher, S. G., Cao, X. B., Bellahcene, M., Dighe, K., Kabir, A. M. N., Quinlan, R. A., Kato, K., Gaestel, M., Marber, M. S. & Heads, R. J., Sept 2009, In: CELL STRESS AND CHAPERONES. 14, 5, p. 477 - 489 13 p.Research output: Contribution to journal › Article › peer-review
Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice
Breckenridge, R. A., Zuberi, Z., Gomes, J., Orford, R., Dupays, L., Felkin, L. E., Clark, J. E., Magee, A. I., Ehler, E., Birks, E. J., Barton, P. J. R., Tinker, A. & Mohun, T. J., Jul 2009, In: Journal of Molecular and Cellular Cardiology. 47, 1, p. 133 - 141 9 p.Research output: Contribution to journal › Article › peer-review
Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse
Nishino, Y., Webb, I. G., Davidson, S. M., Ahmed, A. I., Clark, J. E., Jacquet, S., Shah, A. M., Miura, T., Yellon, D. M., Avkiran, M. & Marber, M. S., 1 Aug 2008, In: Circulation Research. 103, 3, p. 307 - 314 8 p.Research output: Contribution to journal › Article › peer-review
Research

Aerospace Medicine & Physiology Research Group
Understanding physiological responses to aviation and space flight and their medical implications.
News
Professor releases Christmas album to raise money for prostate cancer
James Clark, Professor of Cardiovascular and Physiology Education, has dropped his third Christmas album, Silent Night, to raise money for Prostate Cancer UK.

Physiology graduates contribute £22.6 billion to the UK economy every year
King's Centre for Human & Applied Physiological Sciences contributed to report launched in parliament today

Dr James Clark wins Otto Hutter physiology prize
Dr James Clark, School of Cardiovascular Medicine & Sciences, has been awarded the 2019 Otto Hutter prize for teaching physiology.

Events

King's Showcase Event: Delhi, India
Join us at our exclusive King's Showcase event
Please note: this event has passed.

Inaugural Lecture: Professors James Clark & Gabriel Reedy
Inspiring talks with two of our newly inaugurated professors who will discuss their experience in medical education
Please note: this event has passed.
Features
Meet Professor James Clark as he launches his new charity Christmas album
Professor James Clark is back again with another album of Christmas songs to entertain and pick up the spirits of our students and colleagues after what was a...

5 minutes with James Clark
James Clark is a Reader in Human & Applied Physiology in the School of Cardiovascular Medicine & Sciences. We took 5 minutes with James to learn more about...

50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper-buoyancy floatation versus 15 min sitting upright
Marcos-Lorenzo, D., Lysandrou, C., Sudres, L., Gil-Martinez, A., Swanenburg, J., Clark, J. E. & Green, D. A., 2024, (Accepted/In press) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
An overview of case studies of innovative hybrid flexible pedagogical approaches
Clark, J. E., Detyna, M. & Sami Siddiqui, M., 1 Aug 2024, In: International Journal of Innovation in Education.Research output: Contribution to journal › Article › peer-review
Correction to: Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction (Cells, (2022), 11, 24, (4050), 10.3390/cells11244050)
Ruchaya, P. J., Lewis-McDougall, F. C., Sornkarn, N., Amin, S., Grimsdell, B., Shaalan, A., Gritti, G., Soe, K. T., Clark, J. E. & Ellison-Hughes, G. M., Jun 2024, In: Cells. 13, 11, 895.Research output: Contribution to journal › Comment/debate › peer-review
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation
Knight, H., Abis, G., Kaur, M., Green, H. L. H., Krasemann, S., Hartmann, K., Lynham, S., Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R. T., Eaton, P. & Rudyk, O., 8 Dec 2023, In: Circulation Research. 133, 12, p. 966-988 23 p.Research output: Contribution to journal › Article › peer-review
Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy
Thakore, P., Clark, J. E., Aubdool, A. A., Thapa, D., Starr, A., Fraser, P. A., Farrell-Dillon, K., Fernandes, E. S., McFadzean, I. & Brain, S. D., 4 Apr 2024, In: Biomolecules. 14, 4, 442.Research output: Contribution to journal › Article › peer-review
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation
Knight, H., Abis, G., Kaur, M., Green, H., Krasemann, S., Hartmann, K., Lynham, S., Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R., Eaton, P. & Rudyk, O., 2 Nov 2023, (Accepted/In press) In: Circulation Research. 133Research output: Contribution to journal › Article › peer-review
Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction
Ruchaya, P. J., Lewis-McDougall, F. C., Sornkarn, N., Amin, S., Grimsdell, B., Shaalan, A., Gritti, G., Soe, K. T., Clark, J. E. & Ellison-Hughes, G. M., 14 Dec 2022, In: Cells. 11, 24, 21 p., 4050.Research output: Contribution to journal › Article › peer-review
The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart
Mele, L., Maskell, L. J., Stuckey, D. J., Clark, J. E., Heads, R. J. & Budhram-mahadeo, V. S., 14 Aug 2019, In: Cell death & disease. 10, 8, p. 621-638 18 p., 621.Research output: Contribution to journal › Article › peer-review
Aged-senescent cells contribute to impaired heart regeneration
Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Teoh, T. S., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 2019, In: AGING CELL. 18, 3, e12931.Research output: Contribution to journal › Article › peer-review
Dynamic heart rate response to multi-day unsupported ultra-endurance cycle racing: a case report
Brayson, D., Frigiola, A. & Clark, J. E., 12 Dec 2018, (Accepted/In press) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
The role of single-incision laparoscopic surgery in abdominal and pelvic surgery: a systematic review
Ahmed, K., Wang, T. T., Patel, V. M., Nagpal, K., Clark, J., Ali, M., Deeba, S., Ashrafian, H., Darzi, A., Athanasiou, T. & Paraskeva, P., Feb 2011, In: Surgical endoscopy. 25, 2, p. 378-96 19 p.Research output: Contribution to journal › Review article › peer-review
Detection of anthracycline-induced cardiotoxicity using perfusion-corrected 99mTc sestamibi SPECT
Safee, Z. M., Baark, F., Waters, E. C. T., Veronese, M., Pell, V. R., Clark, J. E., Mota, F., Livieratos, L., Eykyn, T. R., Blower, P. J. & Southworth, R., 2019, In: Scientific Reports. 9, p. 216-227 11 p., 216.Research output: Contribution to journal › Article › peer-review
Tissue acidosis does not mediate the hypoxia selectivity of [64Cu][Cu(ATSM)] in the isolated perfused rat heart
Baark, F., Shaughnessy, F., Pell, V. R., Clark, J. E., Eykyn, T. R., Blower, P. & Southworth, R., 24 Jan 2019, In: Scientific Reports. 9, 10 p., 499.Research output: Contribution to journal › Article › peer-review
The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
De Nicola, G. F., Bassi, R., Nichols, C., Fernandez-Caggiano, M., Golforoush, P. A., Thapa, D., Anderson, R., Martin, E. D., Verma, S., Kleinjung, J., Laing, A., Hutchinson, J. P., Eaton, P., Clark, J. & Marber, M. S., 23 Aug 2018, In: JCI Insight. 3, 16, p. 1-17Research output: Contribution to journal › Article › peer-review
Author Correction: Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
Sharif-Paghaleh, E., Yap, M. L., Puhl, S. L., Badar, A., Torres, J. B., Chuamsaamarkkee, K., Kampmeier, F., Smith, R. A., Clark, J., Blower, P. J., Sacks, S. & Mullen, G. E., 13 Mar 2018, In: Scientific Reports. 8, 1, p. 4687 1 p.Research output: Contribution to journal › Article › peer-review
Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice
Garrett, N., Pombo, J., Umpierrez, M., Clark, J. E., Simmons, M. & Girardi, G., 19 Apr 2018, (E-pub ahead of print) In: JCI Insight. 3, 8Research output: Contribution to journal › Article › peer-review
p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin
Loonat, A. A., Martin, E. D., Sarafraz-Shekary, N., Tilgner, K., Hertz, N. T., Levin, R., Shokat, K. M., Burlingame, A. L., Arabacilar, P., Uddin, S., Thomas, M., Marber, M. S. & Clark, J. E., 31 Dec 2019, In: Faseb Journal. 33, 12, p. 13131-13144 14 p.Research output: Contribution to journal › Article › peer-review
PET Imaging of Cardiac Hypoxia: Hitting Hypoxia Where It Hurts
Pell, V. R., Baark, F., Mota, F., Clark, J. E. & Southworth, R., 2018, In: Current Cardiovascular Imaging Reports. 11, 3, p. 7Research output: Contribution to journal › Review article › peer-review
Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
Sharif-Paghaleh, E., Clark, J., Yap, M. L., Badar, A., Baguna Torres, J., Puhl, S. L., Blower, P. J., Chuamsaamarkkee, K., Kampmeier, F., Smith, R., Sacks, S. H. & Mullen, G. E. D., 23 Nov 2017, In: Scientific Reports. 7, 1, 16090.Research output: Contribution to journal › Article › peer-review
Cardioprotection by an anti-MASP-2 antibody in a murine model of myocardial infarction
Clark, J. E., Dudler, T., Marber, M. S. & Schwaeble, W., 2018, In: Open Heart. 5, e000652.Research output: Contribution to journal › Article › peer-review
Loss of protein kinase novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation and exacerbated ischaemia-reperfusion injury
Francois, A. A., Obasanjo-Blackshire, K., Clark, J. E., Boguslavskyi, A., Holt, M. R., Parker, P. J., Marber, M. S. & Heads, R. J., 16 Oct 2017, (E-pub ahead of print) In: Cardiovascular Research.Research output: Contribution to journal › Article › peer-review
A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy and Heart Failure
Aubdool, A. A., Thakore, P., Argunhan, F., Smillie, S.-J., Schnelle, M., Srivastava, S., Alawi, K. M., Wilde, E., Mitchell, J., Farrell-Dillon, K., Richards, D. A., Maltese, G., Siow, R. C., Nandi, M., Clark, J. E., Shah, A. M., Sams, A. & Brain, S. D., 25 Jul 2017, In: Circulation (Baltimore). 136, 4, p. 367-383Research output: Contribution to journal › Article › peer-review
Effect of postnatal Leptin on cardiac structure and function
Apel, A.-M. S., Shattock, M. J., Poston, L., Pombo, J., Clark, J., Rudyk, O. V. & Coen, C., 2013, In: Acta Obstetricia et Gynecologica Scandinavica.Research output: Contribution to journal › Meeting abstract › peer-review
ELUCIDATING THE ROLE OF P38γ IN PATHOLOGICAL CARDIAC HYPERTROPHY
Loonat, A. A., Hunt, F., Choi, S. H., Marber, M. S., Martin, E. D., T Hertz, N., Levin, B., M Shokat, K., L Burlingame, A., Marber, M. S. & Clark, J., Dec 2014, In: Heart. 100Research output: Contribution to journal › Meeting abstract › peer-review
P38γ mitogen-Activated Protein Kinase is a Mediator of Pathological Cardiac Hypertophy
Clark, J., Sept 2014, In: Heart. 100, 1.Research output: Contribution to journal › Meeting abstract › peer-review
DELETERIOUS EFFECTS OF COLD AIR INHALATION DURING EXERCISE IN CORONARY ARTERY DISEASE PATIENTS: DIFFERENTIAL EFFECTS OF ISOMETRIC AND DYNAMIC EXERCISE
Clark, J., Harwood, A., Fok, H. & Williams, R., Jun 2015, In: Journal of Hypertension. 33Research output: Contribution to journal › Article › peer-review
Response to role of hyperleptinemia in the regulation of blood pressure and cardiac function
Samuelsson, A. M., Clark, J., Rudyk, O., Shattock, M. J., Bae, S. E., South, T., Pombo, J., Redington, K., Uppal, E., Coen, C. W., Poston, L. & Taylor, P. D., Jan 2014, In: Hypertension. 63, 1, 1 p., e2.Research output: Contribution to journal › Letter › peer-review
Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury
Baker, J. O., Tyther, R., Liebetrau, C., Clark, J., Howarth, R., Patterson, T., Möllmann, H., Nef, H., Sicard, P., Kailey, B., Devaraj, R., Redwood, S. R., Kunst, G., Weber, E. & Marber, M. S., May 2015, In: Basic Research in Cardiology. 110, 3, 14 p., 478.Research output: Contribution to journal › Article › peer-review
Moving in extreme environments: inert gas narcosis and underwater activities
Clark, J. E., 24 Feb 2015, In: Extreme physiology & medicine. 4, 7 p., 1.Research output: Contribution to journal › Article › peer-review
Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension
Bodkin, J. V., Thakore, P., Aubdool, A. A., Liang, L., Fernandes, E. S., Nandi, M., Spina, D., Clark, J. E., Aaronson, P. I., Shattock, M. J. & Brain, S. D., Aug 2014, In: Pharmacology research & perspectives. 2, 4, 17 p., e00052.Research output: Contribution to journal › Article › peer-review
Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman
Boguslavskyi, A., Pavlovic, D., Aughton, K., Clark, J. E., Howie, J., Fuller, W. & Shattock, M. J., 1 Oct 2014, In: Cardiovascular Research. 104, p. 72-78 6 p.Research output: Contribution to journal › Article › peer-review
Transient therapeutic inhibition of MASP-2 dependent lectin pathway functional activity provides a significant degree of protection from ischaemia/reperfusion injury in models of myocardial infarction and stroke
Chrysanthou, E., Clark, J., Lynch, N., Dudler, T., Marber, M., Samani, N. J. & Schwaeble, W. J., 2013, 14th European meeting on Complement in Human Disease.Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
De Nicola, G. F., Martin, E. D., Chaikuad, A., Bassi, R., Clark, J., Martino, L., Verma, S., Sicard, P., Tata, R., Atkinson, R. A., Knapp, S., Conte, M. R. & Marber, M. S., Oct 2013, In: NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 20, 10, p. 1182-1190 9 p.Research output: Contribution to journal › Article › peer-review
Trapped Platelets Activated in Ischemia Initiate Ventricular Fibrillation
Dhanjal, T., Medina, R., Leem, J., Clark, J., Southworth, R. & Curtis, M., Oct 2013, In: Circulation-Arrhythmia And Electrophysiology. 6, 5, p. 995-1001 7 p., N/A.Research output: Contribution to journal › Article › peer-review
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing
Evans, M. A., Smart, N., Dubé, K. N., Bollini, S., Clark, J. E., Evans, H. G., Taams, L. S., Richardson, R., Lévesque, M., Martin, P., Mills, K., Riegler, J., Price, A., Lythgoe, M. F. & Riley, P. R., 2 Jul 2013, In: Nature Communications. 4, 2081.Research output: Contribution to journal › Article › peer-review
Experimental hyperleptinemia in neonatal rats leads to selective leptin responsiveness, hypertension, and altered myocardial function
Samuelsson, A. M., Clark, J., Rudyk, O., Shattock, M. J., Bae, S. E., South, T., Pombo, J., Redington, K., Uppal, E., Coen, C. W., Poston, L. & Taylor, P. D., Sept 2013, In: Hypertension. 62, 3, p. 627-633 7 p.Research output: Contribution to journal › Article › peer-review
Patent foramen ovale and scuba diving: a practical guide for physicians on when to refer for screening
Sykes, O. & Clark, J. E., 2013, In: Extreme physiology & medicine. 2, 1, 10.Research output: Contribution to journal › Article › peer-review
Postnatal Leptin Administration in Naive Rat Pups Leads to Leptin Resistance, Hypertension and Gender Specific Myocardial Dysfunction
Samuelsson, A.-M., Clark, J., Shattock, M. J. J., Pombo, J., Coen, C., Poston, L. & Taylor, P. D., Sept 2011, In: Journal of Developmental Origins of Health and Disease. 2, p. S12-S12 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
Advancements in pressure–volume catheter technology – stress remodelling after infarction
Clark, J. & Marber, M., Mar 2013, In: Experimental Physiology. 98, 3, p. 614-621 8 p.Research output: Contribution to journal › Article › peer-review
Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3
Risebro, C. A., Petchey, L. K., Smart, N., Gomes, J., Clark, J., Vieira, J. M., Yanni, J., Dobrzynski, H., Davidson, S., Zuberi, Z., Tinker, A., Shui, B., Tallini, Y. I., Kotlikoff, M. I., Miquerol, L., Schwartz, R. J. & Riley, P. R., 6 Jul 2012, In: Circulation Research. 111, 2, p. e19-e31 13 p.Research output: Contribution to journal › Article › peer-review
The role of RIP2 in p38 MAPK activation in the stressed heart
Jacquet, S., Nisbino, Y., Kumphune, S., Sicard, P., Clark, J., Kobayashi, K. S., Flavell, R. A., Eickhoff, J., Cotten, M. & Marber, M. S., 2 Apr 2008, In: Journal of Molecular and Cellular Cardiology. 44, 4, p. 714-714 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
Schwaeble, W. J., Lynch, N. J., Clark, J. E., Marber, M., Samani, N. J., Ali, Y. M., Dudler, T., Parent, B., Lhotta, K., Wallis, R., Farrar, C. A., Sacks, S., Lee, H., Zhang, M., Iwaki, D., Takahashi, M., Fujita, T., Tedford, C. E. & Stover, C. M., 3 May 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7523 - 7528 6 p.Research output: Contribution to journal › Article › peer-review
Myocardial stress remodelling after regional infarction is independent of glycogen synthase kinase-3 inactivation
Webb, I. G., Sicard, P., Clark, J. E., Redwood, S. & Marber, M. S., Nov 2010, In: Journal of Molecular and Cellular Cardiology. 49, 5, p. 897 - 900 4 p.Research output: Contribution to journal › Article › peer-review
Constitutive glycogen synthase kinase-3α/β activity protects against chronic β-adrenergic remodelling of the heart
Webb, I. G., Nishino, Y., Clark, J. E., Murdoch, C., Walker, S. J., Makowski, M. R., Botnar, R. M., Redwood, S. R., Shah, A. M. & Marber, M. S., Aug 2010, In: Cardiovascular Research. 87, 3, p. 494 - 503 10 p.Research output: Contribution to journal › Article › peer-review
The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning
Sicard, P., Clark, J. E., Jacquet, S., Mohammadi, S., Arthur, J. S. C., O'Keefe, S. J. & Marber, M. S., Jun 2010, In: Journal of Molecular and Cellular Cardiology. 48, 6, p. 1324 - 1328 5 p.Research output: Contribution to journal › Article › peer-review
A Chemical Genetic Approach Reveals That p38 alpha MAPK Activation by Diphosphorylation Aggravates Myocardial Infarction and Is Prevented by the Direct Binding of SB203580
Kumphune, S., Bassi, R., Jacquet, S., Sicard, P., Clark, J. E., Verma, S., Avkiran, M., O'Keefe, S. J. & Marber, M. S., 2010, In: Journal of Biological Chemistry. 285, 5, p. 2968-2975 8 p.Research output: Contribution to journal › Article › peer-review
Identification of Cardiac Myosin-binding Protein C as a Candidate Biomarker of Myocardial Infarction by Proteomics Analysis
Jacquet, S., Yin, X., Sicard, P., Clark, J., Kanaganayagam, G. S., Mayr, M. & Marber, M. S., Dec 2009, In: MOLECULAR AND CELLULAR PROTEOMICS. 8, 12, p. 2687 - 2699 13 p.Research output: Contribution to journal › Article › peer-review
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia
Gorog, D. A., Jabr, R. I., Tanno, M., Sarafraz, N., Clark, J. E., Fisher, S. G., Cao, X. B., Bellahcene, M., Dighe, K., Kabir, A. M. N., Quinlan, R. A., Kato, K., Gaestel, M., Marber, M. S. & Heads, R. J., Sept 2009, In: CELL STRESS AND CHAPERONES. 14, 5, p. 477 - 489 13 p.Research output: Contribution to journal › Article › peer-review
Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice
Breckenridge, R. A., Zuberi, Z., Gomes, J., Orford, R., Dupays, L., Felkin, L. E., Clark, J. E., Magee, A. I., Ehler, E., Birks, E. J., Barton, P. J. R., Tinker, A. & Mohun, T. J., Jul 2009, In: Journal of Molecular and Cellular Cardiology. 47, 1, p. 133 - 141 9 p.Research output: Contribution to journal › Article › peer-review
Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse
Nishino, Y., Webb, I. G., Davidson, S. M., Ahmed, A. I., Clark, J. E., Jacquet, S., Shah, A. M., Miura, T., Yellon, D. M., Avkiran, M. & Marber, M. S., 1 Aug 2008, In: Circulation Research. 103, 3, p. 307 - 314 8 p.Research output: Contribution to journal › Article › peer-review
Research

Aerospace Medicine & Physiology Research Group
Understanding physiological responses to aviation and space flight and their medical implications.
News
Professor releases Christmas album to raise money for prostate cancer
James Clark, Professor of Cardiovascular and Physiology Education, has dropped his third Christmas album, Silent Night, to raise money for Prostate Cancer UK.

Physiology graduates contribute £22.6 billion to the UK economy every year
King's Centre for Human & Applied Physiological Sciences contributed to report launched in parliament today

Dr James Clark wins Otto Hutter physiology prize
Dr James Clark, School of Cardiovascular Medicine & Sciences, has been awarded the 2019 Otto Hutter prize for teaching physiology.

Events

King's Showcase Event: Delhi, India
Join us at our exclusive King's Showcase event
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Inaugural Lecture: Professors James Clark & Gabriel Reedy
Inspiring talks with two of our newly inaugurated professors who will discuss their experience in medical education
Please note: this event has passed.
Features
Meet Professor James Clark as he launches his new charity Christmas album
Professor James Clark is back again with another album of Christmas songs to entertain and pick up the spirits of our students and colleagues after what was a...

5 minutes with James Clark
James Clark is a Reader in Human & Applied Physiology in the School of Cardiovascular Medicine & Sciences. We took 5 minutes with James to learn more about...
