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King’s People

Biography

Jennie is a Research Fellow working in Timothy Tree’s group in the Autoimmunity and Immunoregulation Laboratory. As part of our Type 1 diabetes (T1D) research, we are using state-of-the-art technologies, continuously designing, optimising and achieving robust assays that we then use to perform comprehensive immune monitoring for clinical trials and longitudinal studies. Primarily we receive blood samples to monitor change in immunophenotypes and function of a broad range of peripheral blood cell subsets for trials that aim to either deplete or modulate pathogenic cells or to induce tolerance, for example, by increasing the number or function of regulatory T cells, ultimately to preserve pancreatic beta cell function. Since T1D is a very heterogeneous autoimmune disease, the aims of therapies are not only to assess safety and efficacy of the treatment but also to identify potential biomarkers that could stratify subjects with T1D and target different subsets of individuals to different therapies to maximise their chance of responding to the treatment.

  • Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

    Liu, Y. F., Powrie, J., Arif, S., Yang, J. H. M., Williams, E., Khatri, L., Joshi, M., Lhuillier, L., Fountoulakis, N., Smith, E., Beam, C., Lorenc, A., Peakman, M. & Tree, T., 1 Apr 2022, In: Diabetes. 71, 4, p. 722-732 11 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.2337/db21-0728

  • Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes

    Immunology of Diabetes Society T-Cell Cytometry Group, Yang, J. H. M., Ward-Hartstonge, K. A., Perry, D. J., Blanchfield, J. L., Posgai, A. L., Wiedeman, A. E., Diggins, K., Rahman, A., Tree, T. I. M., Brusko, T. M., Levings, M. K., James, E. A., Kent, S. C., Speake, C., Homann, D. & Long, S. A., 4 Mar 2022, In: European Journal of Immunology. 52, 3, p. 372-388 17 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/eji.202049067

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

    Cossarizza, A., Chang, H. D., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., Bacher, P., Bari, S., Barnaba, V., Barros-Martins, J., Baumjohann, D., Beccaria, C. G., Bernardo, D., Boardman, D. A., Borger, J., Böttcher, C., & 173 othersBrockmann, L., Burns, M., Busch, D. H., Cameron, G., Cammarata, I., Cassotta, A., Chang, Y., Chirdo, F. G., Christakou, E., Čičin-Šain, L., Cook, L., Corbett, A. J., Cornelis, R., Cosmi, L., Davey, M. S., De Biasi, S., De Simone, G., del Zotto, G., Delacher, M., Di Rosa, F., Santo, J. D., Diefenbach, A., Dong, J., Dörner, T., Dress, R. J., Dutertre, C. A., Eckle, S. B. G., Eede, P., Evrard, M., Falk, C. S., Feuerer, M., Fillatreau, S., Fiz-Lopez, A., Follo, M., Foulds, G. A., Fröbel, J., Gagliani, N., Galletti, G., Gangaev, A., Garbi, N., Garrote, J. A., Geginat, J., Gherardin, N. A., Gibellini, L., Ginhoux, F., Godfrey, D. I., Gruarin, P., Haftmann, C., Hansmann, L., Harpur, C. M., Hayday, A. C., Heine, G., Hernández, D. C., Herrmann, M., Hoelsken, O., Huang, Q., Huber, S., Huber, J. E., Huehn, J., Hundemer, M., Hwang, W. Y. K., Iannacone, M., Ivison, S. M., Jäck, H. M., Jani, P. K., Keller, B., Kessler, N., Ketelaars, S., Knop, L., Knopf, J., Koay, H. F., Kobow, K., Kriegsmann, K., Kristyanto, H., Krueger, A., Kuehne, J. F., Kunze-Schumacher, H., Kvistborg, P., Kwok, I., Latorre, D., Lenz, D., Levings, M. K., Lino, A. C., Liotta, F., Long, H. M., Lugli, E., MacDonald, K. N., Maggi, L., Maini, M. K., Mair, F., Manta, C., Manz, R. A., Mashreghi, M. F., Mazzoni, A., McCluskey, J., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Monin, L., Moretta, L., Multhoff, G., Muñoz, L. E., Muñoz-Ruiz, M., Muscate, F., Natalini, A., Neumann, K., Ng, L. G., Niedobitek, A., Niemz, J., Almeida, L. N., Notarbartolo, S., Ostendorf, L., Pallett, L. J., Patel, A. A., Percin, G. I., Peruzzi, G., Pinti, M., Pockley, A. G., Pracht, K., Prinz, I., Pujol-Autonell, I., Pulvirenti, N., Quatrini, L., Quinn, K. M., Radbruch, H., Rhys, H., Rodrigo, M. B., Romagnani, C., Saggau, C., Sakaguchi, S., Sallusto, F., Sanderink, L., Sandrock, I., Schauer, C., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schober, K., Schoen, J., Schuh, W., Schüler, T., Schulz, A. R., Schulz, S., Schulze, J., Simonetti, S., Singh, J., Sitnik, K. M., Stark, R., Starossom, S., Stehle, C., Szelinski, F., Tan, L., Tarnok, A., Tornack, J., Tree, T. I. M., van Beek, J. J. P., van de Veen, W., van Gisbergen, K., Vasco, C., Verheyden, N. A., von Borstel, A., Ward-Hartstonge, K. A., Warnatz, K., Waskow, C., Wiedemann, A., Wilharm, A., Wing, J., Wirz, O., Wittner, J., Yang, J. H. M. & Yang, J., Dec 2021, In: European Journal of Immunology. 51, 12, p. 2708-3145 438 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/eji.202170126

  • A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

    Marwaha, A. K., Chow, S., Pesenacker, A. M., Cook, L., Sun, A., Long, S. A., Yang, J. H. M., Ward-Hartstonge, K. A., Williams, E., Domingo-Vila, C., Halani, K., Harris, K. M., Tree, T. I. M., Levings, M. K., Elliott, T., Tan, R. & Dutz, J. P., 13 Nov 2021, (E-pub ahead of print) In: Immunotherapy advances. 2, 1 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/immadv/ltab022

  • Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): Trial protocol

    Gregory, J. W., Carter, K., Cheung, W. Y., Holland, G., Bowen-Morris, J., Luzio, S., Dunseath, G., Tree, T., Yang, J. H. M., Marwaha, A., Ali, M. A., Bashir, N., Hutchings, H. A., Fegan, G. W., Stenson, R., Hiles, S., Marques-Jones, S., Brown, A., Tatovic, D. & Dayan, C., 18 Oct 2021, In: BMJ Open. 11, 10, e049595. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1136/bmjopen-2021-049595

  • Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

    Ferreira, R. C., Castro Dopico, X., Oliveira, J. J., Rainbow, D. B., Yang, J. H., Trzupek, D., Todd, S. A., McNeill, M., Steri, M., Orrù, V., Fiorillo, E., Crouch, D. J. M., Pekalski, M. L., Cucca, F., Tree, T. I., Vyse, T. J., Wicker, L. S. & Todd, J. A., 8 Nov 2019, In: Frontiers in Immunology. 10, 2606. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2019.02606

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andrä, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S., Barnaba, V., & 416 othersBarros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Büscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., Čičin-Šain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dörner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Förster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., González-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grützkau, A., Haftmann, C., Hahn, J., Hammad, H., Hämmerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernández, D. C., Herrera, G., Herrmann, M., Hess, C., Höfer, T., Hoffmann, P., Hogquist, K., Holland, T., Höllt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jäck, H. M., Jani, P. K., Jávega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kühne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., LaRosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. G., Lohoff, M., Lombardi, G., Lopez, L., López-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martínez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueröder, C., Mazzoni, A., McCluskey, J., McGrath, M., McGuire, H. M., McInnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjösberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Müller, S., Multhoff, G., Muñoz, L. E., Münz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Núñez, G., O'Connor, J. E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T. R. D. J., Rahmig, S., Rahn, H. P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmüller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schüler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scottá, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tárnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J. & Zychlinsky, A., 1 Oct 2019, In: European Journal of Immunology. 49, 10, p. 1457-1973 517 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/eji.201970107

  • Phenotypic analysis of human lymph nodes in subjects with new-onset type 1 diabetes and healthy individuals by flow cytometry

    Yang, J. H. M., Khatri, L., Mickunas, M., Williams, E., Tatovic, D., Ali, M. A., Young, P., Moyle, P., Sahni, V., Wang, R., Kaur, R., Tannahill, G. M., Beaton, A. R., Gerlag, D. M., Savage, C. O. S., Rosen, A. N., Waldron-Lynch, F., Dayan, C. M. & Tree, T. I. M., 1 Jan 2019, In: Frontiers in Immunology. 10, OCT, 2547. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2019.02547

  • Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

    Ali, M. A., Liu, Y-F., Arif, S., Tatovic, D., Shariff, H., Gibson, V. B., Yusuf, N., Baptista, R., Eichmann, M., Petrov, N., Heck, S., Yang, J. H. M., Tree, T. I. M., Pujol-Autonell, I., Yeo, L., Baumard, L. R., Stenson, R., Howell, A., Clark, A., Boult, Z., & 19 othersPowrie, J., Adams, L., Wong, F. S., Luzio, S., Dunseath, G., Green, K., O'Keefe, A., Bayly, G., Thorogood, N., Andrews, R., Leech, N., Joseph, F., Nair, S., Seal, S., Cheung, H., Beam, C., Hills, R., Peakman, M. & Dayan, C. M., 9 Aug 2017, In: Science Translational Medicine. 9, 402, 10 p., eaaf7779. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1126/scitranslmed.aaf7779

  • IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors

    Whitehouse, G., Gray, E., Mastoridis, S., Merritt, E., Kodela, E., Yang, J. H. M., Danger, R., Mairal, M., Christakoudi, S., Lozano, J. J., Macdougall, I. C., Tree, T. I. M., Sanchez-Fueyo, A. & Martinez-Llordella, M., 3 Jul 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7083-7088 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1073/pnas.1620835114
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