Dr Jennie (Hsiu Mien) Yang Academics Research Fellow Contact details jennie.yang@kcl.ac.uk (0) 20 7188 3386
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression Ferreira, R. C., Castro Dopico, X., Oliveira, J. J., Rainbow, D. B., Yang, J. H., Trzupek, D., Todd, S. A., McNeill, M., Steri, M., Orrù, V., Fiorillo, E., Crouch, D. J. M., Pekalski, M. L., Cucca, F., Tree, T. I., Vyse, T. J., Wicker, L. S. & Todd, J. A., 8 Nov 2019, In : Frontiers in Immunology. 10, 2606. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3389/fimmu.2019.02606 Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andrä, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S., Barnaba, V. & 416 others, Barros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Büscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., ÄŒiÄin-Å ain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dörner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Förster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., González-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grützkau, A., Haftmann, C., Hahn, J., Hammad, H., Hämmerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernández, D. C., Herrera, G., Herrmann, M., Hess, C., Höfer, T., Hoffmann, P., Hogquist, K., Holland, T., Höllt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jäck, H. M., Jani, P. K., Jávega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kühne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., LaRosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. G., Lohoff, M., Lombardi, G., Lopez, L., López-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martínez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueröder, C., Mazzoni, A., McCluskey, J., McGrath, M., McGuire, H. M., McInnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjösberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Müller, S., Multhoff, G., Muñoz, L. E., Münz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Núñez, G., O'Connor, J. E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T. R. D. J., Rahmig, S., Rahn, H. P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmüller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schüler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scottá, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tárnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J. & Zychlinsky, A., 1 Oct 2019, In : European Journal of Immunology. 49, 10, p. 1457-1973 517 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/eji.201970107 Phenotypic analysis of human lymph nodes in subjects with new-onset type 1 diabetes and healthy individuals by flow cytometry Yang, J. H. M., Khatri, L., Mickunas, M., Williams, E., Tatovic, D., Ali, M. A., Young, P., Moyle, P., Sahni, V., Wang, R., Kaur, R., Tannahill, G. M., Beaton, A. R., Gerlag, D. M., Savage, C. O. S., Rosen, A. N., Waldron-Lynch, F., Dayan, C. M. & Tree, T. I. M., 1 Jan 2019, In : Frontiers in Immunology. 10, OCT, 2547. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3389/fimmu.2019.02547 Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes Ali, M. A., Liu, Y-F., Arif, S., Tatovic, D., Shariff, H., Gibson, V. B., Yusuf, N., Baptista, R., Eichmann, M., Petrov, N., Heck, S., Yang, J. H. M., Tree, T. I. M., Pujol-Autonell, I., Yeo, L., Baumard, L. R., Stenson, R., Howell, A., Clark, A., Boult, Z. & 19 others, Powrie, J., Adams, L., Wong, F. S., Luzio, S., Dunseath, G., Green, K., O'Keefe, A., Bayly, G., Thorogood, N., Andrews, R., Leech, N., Joseph, F., Nair, S., Seal, S., Cheung, H., Beam, C., Hills, R., Peakman, M. & Dayan, C. M., 9 Aug 2017, In : Science Translational Medicine. 9, 402, p. 1-9 aaf7779. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1126/scitranslmed.aaf7779 IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors Whitehouse, G., Gray, E., Mastoridis, S., Merritt, E., Kodela, E., Yang, J. H. M., Danger, R., Mairal, M., Christakoudi, S., Lozano, J. J., Macdougall, I. C., Tree, T. I. M., Sanchez-Fueyo, A. & Martinez-Llordella, M., 3 Jul 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7083-7088 6 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1073/pnas.1620835114 Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial Todd, J. A., Evangelou, M., Cutler, A. J., Pekalski, M. L., Walker, N. M., Stevens, H. E., Porter, L., Smyth, D. J., Rainbow, D. B., Ferreira, R. C., Esposito, L., Hunter, K. M. D., Loudon, K., Irons, K., Yang, J. H., Bell, C. J. M., Schuilenburg, H., Heywood, J., Challis, B., Neupane, S. & 18 others, Clarke, P., Coleman, G., Dawson, S., Goymer, D., Anselmiova, K., Kennet, J., Brown, J., Caddy, S. L., Lu, J., Greatorex, J., Goodfellow, I., Wallace, C., Tree, T. I., Evans, M., Mander, A. P., Bond, S., Wicker, L. S. & Waldron-Lynch, F., 11 Oct 2016, In : PL o S Medicine. 13, 10, e1002139. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1371/journal.pmed.1002139 Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes Yang, J. H. M., Cutler, A. J., Ferreira, R. C., Reading, J. L., Cooper, N. J., Wallace, C., Clarke, P., Smyth, D. J., Boyce, C. S., Gao, G-J., Todd, J. A., Wicker, L. S. & Tree, T. I. M., Nov 2015, In : Diabetes. 64, 11, p. 3891-902 12 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.2337/db15-0516 Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity Reading, J. L., Yang, J. H. M., Sabbah, S., Skowera, A., Knight, R. R., Pinxteren, J., Vaes, B., Allsopp, T., Ting, A. E., Busch, S., Raber, A., Deans, R. & Tree, T. I. M., 1 May 2013, In : Journal of Immunology. 190, 9, p. 4542-52 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.4049/jimmunol.1202710 Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function Garg, G., Tyler, J. R., Yang, J. H. M., Cutler, A. J., Downes, K., Pekalski, M., Bell, G. L., Nutland, S., Peakman, M., Todd, J. A., Wicker, L. S. & Tree, T. I. M., 1 May 2012, In : Journal of Immunology. 188, 9, p. 4644-4653 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.4049/jimmunol.1100272 Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing Heap, G. A., Yang, J. HM., Downes, K., Healy, B. C., Hunt, K. A., Bockett, N., Franke, L., Dubois, P. C., Mein, C. A., Dobson, R. J., Albert, T. J., Rodesch, M. J., Clayton, D. G., Todd, J. A., van Heel, D. A. & Plagnol, V., 1 Jan 2010, In : Human Molecular Genetics. 19, 1, p. 122-134 13 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1093/hmg/ddp473 View all publications