Biography
The Centre for Clinical Infection & Diagnostics Research (CIDR) is a joint initiative established by Kings College London and Guy’s and St Thomas’ Hospital established in 2011. It is embedded within the Directorate of Infection on the St Thomas Hospital campus adjacent to diagnostic microbiology and virology laboratories, clinical infectious disease and infection prevention & control teams and the wards. It hosts between 10 and 15 staff: clinical academics, post-doctoral scientists, healthcare-scientists, research nurses and trainees (including NIHR clinical lecturers & academic clinical fellows during or post PhD/MD fellowships).
Our main focus is to conduct research providing evidence to help control antimicrobial resistance and healthcare-associated infections, particularly by improving the speed and utility of infectious diseases diagnostics. Our core strength is conducting studies involving patients and patient samples (observational/surveillance studies, interventional clinical trials and diagnostic evaluation studies). Linked with these studies we create clinical datasets to develop robust clinical phenotypes that support clinical impact assessments and health economic evaluations and collaborations with local, national and international groups. The co-location of all participants in the translational research pathway is a distinctive success factor. It brings insight into unmet clinical need, early warning for emerging pathogens, the ability to retrieve precious time-critical samples for research studies and to ensure we target benefit of new interventions for patients and clinical teams. Healthcare scientists and clinical users are core members of the research team throughout, so that SOPs, quality assurance, laboratory workflow, ISO accreditation, clinical utility and cost-effectiveness assessments can be considered from the start to support rapid translation into service and patient benefit.
For many years the focus was S. aureus/MRSA, C. difficile and PCR-based diagnostic evaluation studies in the laboratory or at point-of-care. It is now increasingly Multi-Drug Resistant Gram-negative bacteria (MDR-GNB), and evaluation of new technologies particularly long-read, real-time genetic sequencing using nanopore technology. In 2016 we also opened an MHRA licenced Faecal Microbiome Transplantation service & research facility, which provides material for an increasing number of research studies and patients with recurrent C. difficile infection (>100 patients treated with over 90% success). We are currently developing a new acute respiratory infection research theme working with critical care services and collaborators at Public Health England. Priorities include implementation of rapid diagnostics for known, emerging and novel viral and bacterial pathogens including targeted arrays and metagenomic approaches. A particular need is to support the critical care Extra Corporeal Membrane Oxygenation (ECMO) service, which sees over 200 patients a year, and the recently commissioned on-site respiratory High Consequence Infectious Diseases centre that opened in 2018.
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Improving the uptake and SusTainability of Effective interventions to promote Prudent antibiotic Use and Primary care (STEP-UP) Team , 3 Dec 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 71, 9, p. e415-e420 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1093/cid/ciaa136
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Seow, J., Graham, C., Merrick, B., Acors, S., Pickering, S., Steel, K. J. A., Hemmings, O., O'Byrne, A., Kouphou, N., Galao, R. P., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Huettner, I., Jimenez-Guardeño, J. M., Lista, M. J., Temperton, N., Snell, L. B. & 22 others, Bisnauthsing, K., Moore, A., Green, A., Martinez, L., Stokes, B., Honey, J., Izquierdo-Barras, A., Arbane, G., Patel, A., Tan, M. K. I., O'Connell, L., O'Hara, G., MacMahon, E., Douthwaite, S., Nebbia, G., Batra, R., Martinez-Nunez, R., Shankar-Hari, M., Edgeworth, J. D., Neil, S. J. D., Malim, M. H. & Doores, K. J., 1 Dec 2020, In : Nature Microbiology. 5, 12, p. 1598-1607 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41564-020-00813-8
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Vink, J., Edgeworth, J. & Bailey, S. L., Nov 2020, In : Journal of Hospital Infection. 106, 3, p. 419-428 10 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1016/j.jhin.2020.09.006
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Lim, C., Miliya, T., Chansamouth, V., Aung, M. T., Karkey, A., Teparrukkul, P., Rahul, B., Lan, N. P. H., Stelling, J., Turner, P., Ashley, E., van Doorn, H. R., Lin, H. N., Ling, C., Hinjoy, S., Iamsirithaworn, S., Dunachie, S., Wangrangsimakul, T., Hantrakun, V., Schilling, W. & 12 others, Yen, L. M., Tan, L. V., Hlaing, H. H., Mayxay, M., Vongsouvath, M., Basnyat, B., Edgeworth, J., Peacock, S. J., Thwaites, G., Day, N. P., Cooper, B. S. & Limmathurotsakul, D., 2 Oct 2020, In : Journal of Medical Internet Research. 22, 10, p. e19762 e19762. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.2196/19762
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Laing, A. G., Lorenc, A., del Molino del Barrio, I., Das, A., Fish, M., Monin, L., Muñoz-Ruiz, M., McKenzie, D. R., Hayday, T. S., Francos-Quijorna, I., Kamdar, S., Joseph, M., Davies, D., Davis, R., Jennings, A., Zlatareva, I., Vantourout, P., Wu, Y., Sofra, V., Cano, F. & 30 others, Greco, M., Theodoridis, E., Freedman, J., Gee, S., Chan, J. N. E., Ryan, S., Bugallo-Blanco, E., Peterson, P., Kisand, K., Haljasmägi, L., Chadli, L., Moingeon, P., Martinez, L., Merrick, B., Bisnauthsing, K., Brooks, K., Ibrahim, M. A. A., Mason, J., Lopez Gomez, F., Babalola, K., Abdul-Jawad, S., Cason, J., Mant, C., Seow, J., Graham, C., Doores, K. J., Di Rosa, F., Edgeworth, J., Shankar-Hari, M. & Hayday, A. C., 1 Oct 2020, In : Nature Medicine. 26, 10, p. 1623-1635 13 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41591-020-1038-6
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Pickering, S., Betancor, G., Galão, R. P., Merrick, B., Signell, A. W., Wilson, H. D., Kia Ik, M. T., Seow, J., Graham, C., Acors, S., Kouphou, N., Steel, K. J. A., Hemmings, O., Patel, A., Nebbia, G., Douthwaite, S., O'Connell, L., Luptak, J., McCoy, L. E., Brouwer, P. & 11 others, van Gils, M. J., Sanders, R. W., Martinez Nunez, R., Bisnauthsing, K., O'Hara, G., MacMahon, E., Batra, R., Malim, M. H., Neil, S. J. D., Doores, K. J. & Edgeworth, J. D., 24 Sep 2020, In : PLoS Pathogens. 16, 9, p. e1008817 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1371/journal.ppat.1008817
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Edgeworth, J. D., Batra, R., Nebbia, G., Bisnauthsing, K., MacMahon, E., Sudhanva, M., Douthwaite, S., Goldenberg, S., O'Hara, G., Shankar-Hari, M., Doores, K. J., Martinez-Nunez, R., Hemsley, C., Price, N. M., Lockett, J., Lechler, R. I., Neil, S. J. D. & Malim, M. H., Sep 2020, In : PLoS Pathogens. 16, 9, p. e1008898 e1008898. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1371/journal.ppat.1008898
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Shaw, A. M., Hyde, C., Merrick, B., James-Pemberton, P., Squires, B. K., Olkhov, R. V., Batra, R., Patel, A., Bisnauthsing, K., Nebbia, G., MacMahon, E., Douthwaite, S., Malim, M., Neil, S., Martinez Nunez, R., Doores, K., Mark, T. K. I., Signell, A. W., Betancor, G., Wilson, H. D. & 3 others, Galão, R. P., Pickering, S. & Edgeworth, J. D., 21 Aug 2020, In : Analyst. 145, 16, p. 5638-5646 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1039/d0an01066a
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Edgeworth, J. D., Batra, R., Wulff, J. & Harrison, D., 10 Jun 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 12, p. 2530-2540 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1093/cid/ciz720
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Vink, J. P., Otter, J. A. & Edgeworth, J. D., 1 Jan 2020, In : CURRENT OPINION IN GASTROENTEROLOGY. 36, 1, p. 9-16 8 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1097/MOG.0000000000000596